Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study

Freitas, Fernanda; Braga, Antônio; Viggiano, Maurício; Velarde, Luís Guillermo Coca; Maestá, Izildinha; Uberti, Elza; Madi, José Mauro; Yela, Daniela Angerame; Fernandes, Karayna Gil; Silveira, Eduardo; Leal, Elaine Azevedo Soares; Sun, Sue Yazaki; Esteves, Ana Paula Vieira dos Santos; Filho, Jorge Rezende; Amim, Joffre; Elias, Kevin M.; Horowitz, Neil S.; Berkowitz, Ross S.

doi:10.1016/j.ygyno.2020.04.704

Cited by 53 publications

(56 citation statements)

References 24 publications

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“… 25 The mortality of low-risk and high-risk Chinese women is 0.3% and 15.1%, respectively. 3 , 26 Unfortunately, the mechanism underlying choriocarcinoma is still not fully elaborated, and early interventions are lacking. Therefore, identification of hub miRNAs and mRNAs involved in the tumorigenesis and progression of choriocarcinoma is urgently needed.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs

Peng¹,

Zhang²,

Mo³

et al. 2021

OTT

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Objective The aim of the current research was to construct a miRNA-transcription factor (TF)-target gene regulatory network in order to investigate the mechanism underlying choriocarcinoma and to verify the network through the overexpression or silencing of hub miRNAs in vitro. Materials and Methods A mRNA expression dataset and two miRNA expression datasets were analysed to identify differentially expressed genes (DEGs) and miRNAs (DEMs) between normal cells and choriocarcinoma cells. The top 400 upregulated and downregulated DEGs were identified as candidate DEGs, which were then mapped to construct protein–protein interaction (PPI) networks and select hub genes. Moreover, the DGIdb database was utilized to select candidate drugs for hub genes. Moreover, DEM target genes were predicted through the miRWalk2.0 database and overlaid with candidate DEGs to identify the differentially expressed target genes (DETGs). Furthermore, we established miRNA-TF-target gene regulatory networks and performed functional enrichment analysis of hub DEMs. Finally, we transfected mimics or inhibitors of hub DEMs into choriocarcinoma cells and assessed cell proliferation and migration to verify the vital role of hub DEMs in choriocarcinoma. Results A total of 140 DEMs and 400 candidate DEGs were screened from choriocarcinoma cells and normal cells. A PPI network of 400 candidate DEGs was established. Twenty-nine hub genes and 99 associated small molecules were identified to provide potential target drugs for choriocarcinoma treatment. We obtained 70 DETGs of DEMs derived from the intersection between predicted miRNA target genes and candidate DEGs. Subsequently, 3 hub DEMs were selected, and miRNA-TF-target gene regulatory networks containing 4 TFs, 3 TFs and 3 TFs for each network were constructed. The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells. The overexpression or silencing results suggested that 3 dysregulated hub DEMs jointly accelerated the proliferation and migration of choriocarcinoma. Conclusion Association of miRNA-TF-target gene regulatory networks may help us explore the underlying mechanism and provide potential targets for the diagnosis and treatment of choriocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs

Peng¹,

Zhang²,

Mo³

et al. 2021

OTT

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“…Sin embargo, estos estadíos con presencia de metástasis o en estadio IV, el pronóstico es relativamente malo y según las estadísticas de Gran Bretaña, la tasa de supervivencia a 10 años es de alrededor del 49% (1). Cabe resaltar que después de introducir la quimioterapia combinada como tratamiento primario en este grupo, la tasa de supervivencia mejoró drásticamente, logrando una remisión de hasta el 60-70% de los casos (1,17,18).…”

Section: Pronóstico Y Supervivenciaunclassified

Análisis clínico y patológico del coriocarcinoma gestacional

2022

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El coriocarcinoma es una patología infrecuente, pero potencialmente fatal si no se trata. Está incluida dentro de las Neoplasias Trofoblásticas Gestacionales (NTG), un grupo de tumores malignos altamente invasivos, metastásicos y vascularizados. Su presentación tras una gestación a término conlleva peor pronóstico que tras un aborto o una mola hidatiforme, porque refleja un retraso en el diagnóstico y tratamiento. Los elevados niveles de Gonadotropina Coriónica Humana beta (β-hCGesenciales su diagnóstico. El tratamiento debe de ser precoz, basado en quimioterapia con múltiples fármacos idealmente, aunque en ocasiones también se incluyen la cirugía y radioterapia.

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“…Because of GTN’s remarkable sensitivity to chemotherapy, its cure rate can reach 100% and >90% in patients with low-risk (FIGO score <7) and high-risk (7 ≤ FIGO score ≤12) GTN, respectively. 5 However, the prognosis of patients with ultra-high-risk (FIGO score >12) GTN and refractory GTN remains poor, 6–8 and their death is mostly linked to chemoresistance and severe complications, including hemorrhagic metastases, infection, multisystem organ failure, and tumor lysis syndrome. 9 , 10 Patients with high-risk GTN can experience life-threatening events, including severe tumorous hemorrhage, digestive tract perforation, and brain herniation, any time before or during treatment.…”

Section: Introductionmentioning

confidence: 99%

Role of Emergency Surgery for Fatal Complications of Gestational Trophoblastic Neoplasia: A Single-Center Experience

Wang¹,

Han²,

Zhu³

et al. 2022

CMAR

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Purpose High-risk gestational trophoblastic neoplasia (GTN) can lead to fatal complications; however, few reports have assessed emergency surgery as a treatment option for such complications. Thus, this study aimed to analyze the clinical features and prognosis of patients with GTN who underwent emergency surgery. Patients and Methods Thirteen patients with high-risk or ultra-high-risk GTN who underwent emergency surgery for fatal complications in the First Affiliated Hospital of Zhejiang University, School of Medicine from 2013 to 2020 were analyzed, and their medical records were reviewed. The patients’ characteristics and treatment were evaluated with respect to outcomes. Results Thirteen patients with GTN who underwent 15 emergency surgical procedures were identified in our center. The mean International Federation of Gynecology and Obstetrics score of these patients was 14.8 (range, 11–19). Of the 13 patients, six underwent brain surgeries, such as tumor resection (n = 5) and conservative surgery (n = 1). All the patients received multi-agent chemotherapy after emergency surgery, and the mean time from emergency surgery to subsequent chemotherapy was 12.7 days. Of the 13 patients, 10 (77%) were cured and disease-free, with a follow-up period ranging from 3 months to 8 years. All the patients (n = 6) who underwent emergency brain surgery survived and achieved complete remission. Conclusion For patients with high-risk GTN with fatal complications, especially brain lesions, emergency surgery combined with subsequent chemotherapy may provide a favorable prognosis.

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Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study

Cited by 53 publications

References 24 publications

Bioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs

Bioinformatics Analysis of Choriocarcinoma-Related MicroRNA-Transcription Factor-Target Gene Regulatory Networks and Validation of Key miRNAs

Análisis clínico y patológico del coriocarcinoma gestacional

Role of Emergency Surgery for Fatal Complications of Gestational Trophoblastic Neoplasia: A Single-Center Experience

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