Gestational vitamin D3 supplementation and sun exposure significantly influence cord blood vitamin D status and 3-epi-25-hydroxyvitamin D3 levels in term newborns

Vierucci, Francesco; Fusani, Lara; Minucciani, Tania; Belluomini, Maria Paola; Domenici, R; Bracco, Gian Luca; Vaccaro, Angelina; Federico, Giovanni

doi:10.1016/j.cca.2021.11.022

Cited by 5 publications

(3 citation statements)

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“…Some studies have highlighted the importance of C3-epimers in clinical studies and their measurement to estimate VD status. [36][37][38] Most of the VD metabolites are known to be epimerized at the C3 site, with greater levels in infants. 39 The only structural difference between the C3 epimeric forms and the primary forms is the arrangement of the hydroxyl group in the third carbon position (the hydroxyl group at the C3 position is orientated from the a to b orientation) (Fig.…”

Section: Metabolism Of Vdmentioning

confidence: 99%

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Vitamin D metabolites and analytical challenges

et al. 2023

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Section: Metabolism Of Vdmentioning

confidence: 99%

“…Some studies have highlighted the importance of C3-epimers in clinical studies and their measurement to estimate VD status. 36–38 Most of the VD metabolites are known to be epimerized at the C3 site, with greater levels in infants. 39…”

Section: Metabolism Of Vdmentioning

confidence: 99%

Vitamin D metabolites and analytical challenges

et al. 2023

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“…Considering water requirements, formula-fed infants may receive 400 IU/day of vitamin D only when they weigh 5–6 Kg, so only some months after birth and near weaning, when daily milk consumption inevitably reduces [ 9 ]. Finally, as fetal vitamin D stores depend exclusively on maternal vitamin D status, newborns from mothers not receiving vitamin D supplementation and with poor sun exposure are at increased risk of vitamin D deficiency [ 113 ]. For all these reasons, first an expert position statement [ 9 ], followed by international [ 114 ] and national consensus [ 115 ] recommended vitamin D supplementation with 400 IU/day for all infants from birth to 12 months of life, independently of their mode of feeding.…”

Section: Vitamin D Supplementation In Childhoodmentioning

confidence: 99%

Exclusive Breastfeeding and Vitamin D Supplementation: A Positive Synergistic Effect on Prevention of Childhood Infections?

Domenici¹,

Vierucci²

2022

IJERPH

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Human milk is the best food for infants. Breastfeeding has been associated with a reduced risk of viral and bacterial infections. Breast milk contains the perfect amount of nutrients needed to promote infant growth, except for vitamin D. Vitamin D is crucial for calcium metabolism and bone health, and it also has extra-skeletal actions, involving innate and adaptive immunity. As exclusive breastfeeding is a risk factor for vitamin D deficiency, infants should be supplemented with vitamin D at least during the first year. The promotion of breastfeeding and vitamin D supplementation represents an important objective of public health.

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Dynamics of the vitamin D C3-epimer levels in preterm infants

Matějek

Zapletalova

Štěpán

et al. 2023

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives The primary objective was to determine levels of C3-epi-25(OH)D in very low birth weight infants. The secondary objective was to evaluate the possible influence of preterm birth, intrauterine growth restriction (IUGR), and season of birth on the production of C3-epimers. Methods A total of 127 infants with birth weight less than 1,500 g met the inclusion criteria of the study. We examined 25-hydroxyvitamin-D [25(OH)D] levels and C3-epi-25(OH)D in maternal serum before labor, and in cord blood and infants’ serum on days 14 and 28, and at discharge. Results The mean levels (±SD) of C3-epi-25(OH)D of the cord, on day 14, on day 28, and at discharge were 2.2 (2.9), 7.7 (5.5), 11.7 (7.6) and 14.9 (11.7) nmol/L respectively. The proportion of total 25(OH)D as the C3-epimer was 6.9% (cord), 16.3% (day 14), 22.4% (day 28) and 23.3% (discharge). A statistically significant correlation between 25(OH)D and C3-epi-25(OH)D can be demonstrated from birth. The severity of immaturity and IUGR did not affect the production of C3-epimers. In summer/autumn vs. winter/spring, the mean (SD) percentage of total 25(OH)D as the C3-epimer significantly differs only in maternal serum samples and umbilical cord samples (p value <0.001). Conclusions The production of C3-epi-25(OH)D is functional even in the most immature newborns, has fetal origins, and is largely dependent on circulating 25(OH)D. At the end of the first month of life, C3-epimers make up more than 20% of 25(OH)D.

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Gestational vitamin D3 supplementation and sun exposure significantly influence cord blood vitamin D status and 3-epi-25-hydroxyvitamin D3 levels in term newborns

Cited by 5 publications

References 34 publications

Vitamin D metabolites and analytical challenges

Vitamin D metabolites and analytical challenges

Exclusive Breastfeeding and Vitamin D Supplementation: A Positive Synergistic Effect on Prevention of Childhood Infections?

Dynamics of the vitamin D C3-epimer levels in preterm infants

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