Get More Out of Your Data: A New Approach to Agglomeration and Aggregation Studies Using Nanoparticle Impact Experiments

Ellison, Joanna; Tschulik, Kristina; Stuart, Emma J. E.; Jurkschat, Kerstin; Omanović, Dario; Uhlemann, Margitta; Crossley, Alison; Compton, Richard G.

doi:10.1002/open.201300005

Cited by 76 publications

(87 citation statements)

References 15 publications

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“…From the comparison between the SEM and impact data it can be concluded that both sizing methods are in very good agreement throughout the range of investigated NP sizes. This observation indicates that in contrast to previous impact analyses performed in chloride‐containing electrolytes,7, 8 no significant agglomeration—over the time frame of the experiments—of the Ag nanoparticles in the 0.1 M tri‐sodium citrate electrolyte is observed, rendering this a useful methodology for studying the size distribution of Ag nanoparticles in aqueous media.…”

Section: Summary Of the Derived Mean Radii (R) And Standard Deviationcontrasting

confidence: 54%

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Nanoparticle Impacts Show High‐Ionic‐Strength Citrate Avoids Aggregation of Silver Nanoparticles

et al. 2013

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Section: Summary Of the Derived Mean Radii (R) And Standard Deviationcontrasting

confidence: 54%

“…Previous particle coulometry investigations of silver nanoparticles have been complicated by the in situ agglomeration/aggregation of the nanoparticles 7. 8 This arises due to the requirement of relatively high ionic strengths in the electrochemical setup.…”

Section: Summary Of the Derived Mean Radii (R) And Standard Deviationmentioning

confidence: 99%

Nanoparticle Impacts Show High‐Ionic‐Strength Citrate Avoids Aggregation of Silver Nanoparticles

et al. 2013

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“…Beyond being an analytical technique, the direct nano‐impact method also provides a route for investigating more fundamental problems. A first example is the use of the technique for the study and monitoring of solution‐phase nanoparticle agglomeration and aggregation . In a similar vein, the magnetic‐field‐induced agglomeration of Fe 3 O 4 has also been directly evidenced .…”

Section: Section 7: Nanoparticle Voltammetrymentioning

confidence: 99%

Recent Advances in Voltammetry

et al. 2015

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Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can be fully developed and applied to real chemical problems of distinct complexity. This review focuses on the topic areas of: multistep electrochemical processes, voltammetry in ionic liquids, the development and interpretation of theories of electron transfer (Butler–Volmer and Marcus–Hush), advances in voltammetric pulse techniques, stochastic random walk models of diffusion, the influence of migration under conditions of low support, voltammetry at rough and porous electrodes, and nanoparticle electrochemistry. The review of the latter field encompasses both the study of nanoparticle-modified electrodes, including stripping voltammetry and the new technique of ‘nano-impacts’.

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“…Detection of dilute concentrations of pathogens is an especially important goal. The utilization of electrochemical collisions has been demonstrated to be sensitive enough to differentiate nanoparticle aggregates, such as aggregates of silver nanoparticles from monomers and dimers to higher order aggregates (26). Here, we present a technique to selectively detect viruses based on blocking and specific interactions between MCMV, an MCMV-specific antibody, and polystyrene beads (PSBs).…”

Section: Significancementioning

confidence: 99%

Electrochemical detection of a single cytomegalovirus at an ultramicroelectrode and its antibody anchoring

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Hilterbrand

Boika

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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We report observations of stochastic collisions of murine cytomegalovirus (MCMV) on ultramicroelectrodes (UMEs), extending the observation of discrete collision events on UMEs to biologically relevant analytes. Adsorption of an antibody specific for a virion surface glycoprotein allowed differentiation of MCMV from MCMV bound by antibody from the collision frequency decrease and current magnitudes in the electrochemical collision experiments, which shows the efficacy of the method to size viral samples. To add selectivity to the technique, interactions between MCMV, a glycoprotein-specific primary antibody to MCMV, and polystyrene bead "anchors," which were functionalized with a secondary antibody specific to the Fc region of the primary antibody, were used to affect virus mobility. Bead aggregation was observed, and the extent of aggregation was measured using the electrochemical collision technique. Scanning electron microscopy and optical microscopy further supported aggregate shape and extent of aggregation with and without MCMV. This work extends the field of collisions to biologically relevant antigens and provides a novel foundation upon which qualitative sensor technology might be built for selective detection of viruses and other biologically relevant analytes.collisions | cytomegalovirus | electrochemistry | murine cytomegalovirus | virus O ver the past decade, the study of discrete collision events on ultramicroelectrodes (UMEs) has gained attention due to the interest in understanding stochastic phenomena by electrochemistry. By observing the collisions of small particles, there is the possibility that information can be deduced that is not available in ensemble measurements. The electrochemical study of single collision events has been applied to a wide range of hard nanoparticles (NPs), which include metal, metal oxide, and organic NPs [platinum (1), silver (2), gold (3), nickel (4), copper (5), iridium oxide (6), cerium oxide (7), titanium oxide (8), silicon oxide (9), indigo (10), polystyrene (11), and relatively large aggregates of fullerene (12)]. Recently, collisions of soft particles have been investigated, such as toluene droplets (13) and liposomes (14). Also, collisions of toluene and tri-n-propylamine droplets were observed simultaneously by both electrochemical and electrogenerated chemiluminescent (ECL) measurements (15).Similarly, a variety of techniques have been developed to observe these collision events. The interested reader can consult the references for a discussion on each of the techniques used to observe stochastic events electrochemically: blocking (9, 13), electrocatalytic amplification (1), open circuit potential (16), droplet blocking/reactor (13,14), and ECL (15,17,18). The simplest and most reproducible method of observing collisions is a technique termed blocking, which is so named because particles, which are brought to the electrode by a diffusion-limited flux and/or electrophoretic migration, irreversibly adsorb (1) to the electrode surface, blocking the flux of red...

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Get More Out of Your Data: A New Approach to Agglomeration and Aggregation Studies Using Nanoparticle Impact Experiments

Cited by 76 publications

References 15 publications

Nanoparticle Impacts Show High‐Ionic‐Strength Citrate Avoids Aggregation of Silver Nanoparticles

Nanoparticle Impacts Show High‐Ionic‐Strength Citrate Avoids Aggregation of Silver Nanoparticles

Recent Advances in Voltammetry

Electrochemical detection of a single cytomegalovirus at an ultramicroelectrode and its antibody anchoring

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