A considerable amount of research exists about political science careers at community colleges and liberal arts institutions, as well as about training and hiring practices across different types of institutions. However, there is virtually no commentary available on political science careers at comprehensive institutions, where a significant proportion of those in the field will spend their professional careers. The primary goal of this article is to initiate a conversation about working at a comprehensive university, which has both similarities to and important differences with Ph.D.-granting universities and liberal arts institutions. In doing so, we seek to highlight and discuss unique subtleties and complexities in the areas of teaching, research, and service that may provide insight into careers at comprehensive institutions and assist those who may be seeking or have just gained academic positions at such institutions.