Getting hot and bothered…

Novel Approach for Magnetic Nanoparticle-based Hyperthermia for Metastatic Cancer Treatment

“…In addition to thermal damage, transient adverse effects such as vomiting, diarrhea, and nausea may appear. On rare and extreme occasions cardiac, vasculature and cerebral disorders may arise [5,6]. Since these occurrences are highly uncommon, and the ability to control, monitor, and understand hyperthermia and its effects has increased over recent years, its side effects are generally considered to be not serious, especially in comparison to other cancer treatments [5].Several studies testing the clinical benefits of hyperthermia have been performed, providing evidence that hyperthermia is less efficacious when applied as a single therapy, with limiting factors such as the reproducibility of heat deposition into the tumor mass, the formation of hotspots [4,7], and the challenging measurement of the temperature within the tumor and its vicinity.Nevertheless, hyperthermia has been demonstrated in trials to prolong life and decrease disease re-appraisal as an adjuvant therapy, damaging cancer cells and causing radiation and chemosensitization, with some tumors being more responsive than…”

“…In addition to thermal damage, transient adverse effects such as vomiting, diarrhea, and nausea may appear. On rare and extreme occasions cardiac, vasculature and cerebral disorders may arise [5,6]. Since these occurrences are highly uncommon, and the ability to control, monitor, and understand hyperthermia and its effects has increased over recent years, its side effects are generally considered to be not serious, especially in comparison to other cancer treatments [5].…”