Getting <i>CIC</i> of cutaneous soft tissue sarcomas

Gru, Alejandro A.

doi:10.1111/cup.13682

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…The IHC evaluation of a potential MCC calls for consideration of (a) the clinical context of the case, (b) the immunophenotypic overlap between MCC and some morphological mimics (eg, CD99, as in Ewing's sarcoma; PAX‐5 and TdT, as in lymphomas), 45‐47 (c) the fact that subsets of MCC can yield aberrant IHC profiles (eg, MCPyV‐negative MCCs can share IHC profiles in common with metastatic small cell carcinoma of the lung [SCCL]), 34,48 (d) the relative specificity of IHC stains (eg, the superiority of NF and SATB2 in identifying MCC), 49,50 and (e) the limitations of IHC in this context (eg, Ewing's and Ewing's‐like sarcomas require genetic confirmation) 51,52 . In the final analysis, integration of clinical factors, imaging studies and pathological features of the tumor is necessary to establish a final diagnosis.…”

Section: Immunohistochemical Featuresmentioning

confidence: 99%

“…The differential diagnosis of a “small blue round cell” tumor in the skin/subcutis includes primary cutaneous neoplasms and metastases 11,12,14 . Apart from MCC, the first category includes (a) non‐neuroendocrine small cell undifferentiated carcinoma, (b) small cell melanoma, (c) cutaneous lymphoma, and (d) small round cell undifferentiated sarcoma (eg, Ewing and Ewing‐like sarcomas, as skillfully outlined in a recent editorial in this journal) 52 . The capacity of some poorly differentiated angiosarcomas to express neuroendocrine markers deserves recognition in this context 55,56 .…”

Section: Differential Diagnosismentioning

confidence: 99%

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Merkel cell carcinoma: A review

Walsh

Cerroni

2020

J Cutan Pathol

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Merkel cell carcinoma has been a focus of active scientific investigation in recent years and new information on the topic has emerged. Although uncommon, this primary cutaneous neuroendocrine carcinoma, usually involving the head/neck of elderly individuals, has a poor prognosis. Within the past two decades, an increase in the incidence of the tumor and the discovery of its link to the Merkel cell polyomavirus have focused medical attention on the lesion. The resulting studies have improved our understanding of the biology of the neoplasm and contributed to clinical care. Specifically, two pathogenic subsets of the tumor have come to light, the majority due to Merkel cell polyomavirus and the minority caused by ultraviolet radiation‐induced genetic damage. This dichotomy carries prognostic implications favoring the former subset. In addition, having capitalized on the known susceptibility of the tumor to immune influences, investigators have recently discovered its responsiveness to immune checkpoint inhibition. This revelation has constituted a therapeutic milestone at the clinical level. Herein we provide an overview of the topic, outline updates in the field and place an emphasis on dermatopathologic aspects of Merkel cell carcinoma.

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Section: Immunohistochemical Featuresmentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

Merkel cell carcinoma: A review

Walsh

Cerroni

2020

J Cutan Pathol

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“…[ 16 28 36 ] The differential diagnosis includes primary and metastatic neoplasms such as melanomas, lymphomas, other neuroendocrine or nonneuroendocrine small cell undifferentiated carcinomas and sarcomas (particularly cutaneous Ewing's or Ewing’s-like sarcomas). [ 37 ] Of the metastatic tumors in the differential diagnosis, distinction between a deposit of small cell carcinoma of the lung and MCC is the most common diagnostic quandary.…”

Section: H Istopathological Featuresmentioning

confidence: 99%

Merkel cell carcinoma of the eyelid and periocular region

Walsh

2021

Saudi Journal of Ophthalmology

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Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with a high mortality rate. It typically affects elderly Caucasians, with a slight predilection for males. It is associated with chronic sun exposure and/or immunosuppression. Almost half of all cases occur on the head or neck and an estimated 2.5%–10% arise on the eyelids or periocular skin. It ranks as the 5th most common malignant tumor at these sites, preceded in frequency by basal cell, squamous cell and sebaceous carcinoma, as well as melanoma. Its clinical presentation as a violaceous nodule/plaque lacks specificity, and it can be mistaken for cysts, chalazia or basal cell carcinomas. Sub-specialized histopathological and immunohistochemical evaluations are required for diagnosis. Clinical staging defines the extent of disease and governs management. This includes surgery and adjuvant radiotherapy for localized tumors and of late, immunotherapy for metastatic disease. Significant advances in our understanding of the dual etiopathogenesis (Merkel cell polyomavirus- and Ultraviolet radiation-induced) and the biology of the neoplasm have been achieved in recent years. Issuing from the tumor's known susceptibility to host immunity, a recent therapeutic breakthrough has occurred whereby immune checkpoint inhibition has been shown to mitigate advanced disease. These factors and the increased global incidence of the tumor have brought it to the forefront of medical attention. This review provides a clinically relevant update on MCC, with special reference to cases arising on the eyelid/periocular region.

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Getting CIC of cutaneous soft tissue sarcomas

Cited by 2 publications

References 8 publications

Merkel cell carcinoma: A review

Merkel cell carcinoma: A review

Merkel cell carcinoma of the eyelid and periocular region

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