Many studies analyze the medication errors in the hospital setting, but the literature involving the home care setting seems scarce. The aim of this study is to identify the main risk factors that affect the genesis of medication errors and the possible solutions to reduce the phenomenon in the home care setting. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The critical analysis of the literature shows that medication errors in home care occur mainly during transitional care. The main risk factors related to transitional care are poor interprofessional communication, lack of a standardized process for medication reconciliation, the widespread use of computerized tools, and the inadequate integration of the pharmacist into the care team. The strategies to reduce the risk of errors from therapy at home are the implementation of the pharmacist in the health team to ensure accurate medication reconciliation and the use of computerized tools to improve communication between professionals and to reduce the dispersion of information. K E Y W O R D S adverse drug reaction, home care setting, medication errors, nurses 1 BACKGROUND Currently, patient and care safety represents a truly global challenge (World Health Organization [WHO], 2017). In this context, the greatest efforts are focused on medication errors, which represent between 30% and 50% of all errors in healthcare (Dionisi et al., 2021a; Meyer-Massetti et al., 2018b) and unexpected but predictable events that jeopardize patients' health (Giannetta et al., 2020b; National Coordinating Council for Medication Error Reporting & Prevention, 2015; Yetzer et al., 2011). Medication errors were defined as "any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the health care professional, patient, or consumer. Such events may be related to professional practice, health care products, procedures, and systems, including prescribing, order communication, product labeling, packaging and nomenclature, compounding, dispensing, distribution, administration, education, monitoring, and use (National Coordinating Council for Medication Error Reporting and Prevention, 2015).This phenomenon is well documented and studied in literature; several studies document the risk and impact that these events generally have. Among the causes most reported in the literature, we found several factors: inadequate staffing levels (Giannetta et al., 2021), excessive workload and hasty work (Di Simone et al., 2020), and problems related to medication proprieties (Giannetta et al., 2019a(Giannetta et al., , 2019b.Many studies analyze these factors focusing on the hospital setting with few studies instead in the home care setting that seems scarce 876