2020
DOI: 10.1111/acer.14293
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Getting to the Heart of Low Sensitivity to Alcohol: Context Moderates Low Cardiovascular Response to Alcohol in Persons With a Family History of Alcohol Use Disorder

Abstract: Background Low sensitivity to alcohol in persons with a family history of alcoholism (FH+), compared to those without (FH−), contributes to risk for alcohol use disorder (AUD). However, sensitivity of FH+ cardiovascular response to alcohol is not well understood. This gap is significant because cardiovascular processes contribute to emotional regulation and stress response problems theorized to be central to the development and persistence of AUD. This study compared changes in heart rate (HR) and HR variabili… Show more

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Cited by 7 publications
(4 citation statements)
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“…The cue‐exposure paradigm has been previously detailed 34 . In brief, participants were presented with four blocks of pictures.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The cue‐exposure paradigm has been previously detailed 34 . In brief, participants were presented with four blocks of pictures.…”
Section: Methodsmentioning
confidence: 99%
“…It also suggests that the link between physiological reactivity and cognitive biases is contingent on individual difference factors, particularly those that confer risk. We previously showed FHP compared with FHN participants have greater 0.1‐Hz HRV reactivity toward alcohol cues after alcohol administration 34 . The findings that FHP participants show cognitive 27 and physiological 34 biases toward alcohol cues, as well as increased activation in the interoceptive cortex, 28 imply that shared familial factor that are associated with differential risk for AUD importantly affect interoceptive pathways.…”
Section: Introductionmentioning
confidence: 93%
“…Alcohol has an acute effect on cardiovascular dynamics Vaschillo et al, 2008), and those same psychophysiological measures seem to underlie individual differences in interoceptive capacity (Leganes-Fonteneau, Bates, Muzumdar, et al, 2021). By examining the physiological correlates of alcohol administration we will be better able to unveil mechanistic perspectives supporting changes in interoception, as a possible source of risk for AUD (Bates et al, 2020). This would also be relevant for predictive coding perspectives of interoceptive inference and their relationship to addiction and other mental health disorders, as drug consumption could be motivated by a drive to elicit predicted bodily states or to reduce interoceptive prediction errors (Paulus et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…A large follow-up study of emerging adult drinkers who were stratified by a biobehavioral risk marker of familial history of alcohol use disorder (FH+) found that FH + drinkers showed less suppression of 0.1 Hz HRV index of cardiovascular reactivity and modulation by alcohol, especially in response to negatively valenced emotional cues and alcohol-related cues, compared to those without this familial history (Bates et al, 2020 ). Yet, resting state HRV and reactivity to neutral cues did not vary between groups.…”
Section: The Cardiac Neuroscience Laboratory Todaymentioning
confidence: 99%