GH responses to two consecutive bouts of whole body vibration, maximal voluntary contractions or vibration alternated with maximal voluntary contractions administered at 2-h intervals in healthy adults

Sartório, Alessandro; Lafortuna, Claudio L.; Maffiuletti, Nicola A.; Agosti, Fiorenza; Marazzi, Nicoletta; Rastelli, F.; Rigamonti, Antonello E.; Muller, EE

doi:10.1016/j.ghir.2010.09.004

Cited by 16 publications

(17 citation statements)

References 34 publications

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“…Although the GH peak range was wide, the whole pattern of GH responsiveness was comparable among all the subjects. It is noteworthy that the GH-releasing effect of WBV in this group of obese subjects was quantitatively comparable to that previously observed by our group in healthy normal-weight subjects receiving the same WBV stimulus (GH peaks 4.3 ± 3.5 ng/ml vs. 5.1 ± 1.9 ng/ml) [11,17]. …”

Section: Discussionsupporting

confidence: 89%

“…The positive correlation between serum GH levels and blood lactate concentrations would suggest a potential role of lactate in the mechanism underlying the WBV-induced GH secretion, as already hypothesized in our previous studies in healthy normal-weight subjects [11,17]. However, the finding of higher blood lactate levels after WBV+S, which stimulated the same GH release like WBV alone, forces us to keep some caution in considering lactate as an univocal determinant of WBV-induced GH secretion [41].…”

Section: Discussionsupporting

confidence: 67%

“…As shown by recent studies [9,10,11,17], WBV exercise is capable to increase GH secretion in healthy individuals, but, to the best of our knowledge, no studies have so far investigated the effects of acute WBV on GH levels in obese subjects. …”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the combination of maximal voluntary isometric contractions (MVC) with WBV was also associated with significant greater GH responses in healthy normal-weight- subjects [17], thus indicating that the GH-releasing effect of WBV is not maximal in this experimental setting. These findings in normal-weight subjects, combined with the results of the present study conducted in obese patients, would indicate that high-intensity exercise stimulates GH secretion through neuroendocrine mechanisms different from those of WBV.…”

Section: Discussionmentioning

confidence: 99%

“…growth hormone-releasing hormone (GHRH), hexarelin, aerobic exercise, etc.) [12,13,14,15,16], administration of two consecutive bouts of WBV interspread by a 2-hour interval is associated with a blunting of GH responsiveness [17], thus suggesting the existence of a common mechanism underlying stimulation of somatotropic axis. By contrast, we have recently demonstrated that non-voluntary physical exercise (in the form of electrical stimulation of lower limb muscles) was capable to maintain GH responsiveness also after a 2nd bout repeated after a 2-hour interval [18], thus indicating a different mechanism operating specifically in this experimental setting.…”

Section: Introductionmentioning

confidence: 99%

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Growth Hormone-Releasing Effects of Whole Body Vibration Alone or Combined with Squatting plus External Load in Severely Obese Female Subjects

Giunta

Cardinale²,

Agosti³

et al. 2012

Obes Facts

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Background: Whole body vibration (WBV) has been reported to exert growth hormone(GH)-releasing effects in healthy subjects. Despite the potential of WBV to positively affect body composition changes via lipolytic effects, few studies have been performed in obese subjects to date. Methods: This studyevaluated the acute effects of WBV alone or in combination with squatting plus external load (WBV+S) on serum GH levels and blood lactate concentrations in 7 severely obese women (age 22 ± 5 years; BMI 39.9 ± 2.9 kg/m²). Results: WBV and WBV+S determined a significant GH increase (mean GH peaks 5.1 ± 1.9 ng/ml, p < 0.001 vs. basal, and 6.5 ± 3.7 ng/ml, p < 0.001 vs. basal, respectively), GH peaks occurring immediately after both exercise sessions. No significant differences were observed between GH peaks and GH net incremental area under the curve (nAUC) after both conditions (p = 0.39 and p = 0.53, respectively), the whole pattern of GH responsiveness being comparable among all the subjects. Lactate concentrations increased after both conditions (mean lactate peaks 2.0 ± 0.5 mmol/l, p < 0.05 vs. basal, and 4.5 ± 2.0 mmol/l, p < 0.001 vs. basal, respectively). The lactate response was significantly higher after WBV+S than after WBV (p < 0.05). Baseline GH and GH peak values positively correlated to baseline lactate and lactate peak concentrations in both conditions (R² = 0.64, p < 0.001, and R² = 0.52, p < 0.05, respectively). Conclusions: WBV alone stimulates GH release and lactate production in severely obese female subjects, with no additive effect when combined with squatting plus external load. Further additional studies are required to verify the chronic effects of WBV exercise on the GH/IGF-1 system, which could represent a potentially effective approach for weight management in obese subjects.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 67%