Health is closely tied to human development and the overall development of a nation. Indeed, throughout history, improved public health has been a major determinant of development. Within this context, the consequences of infectious diseases including the novel Coronavirus are not in doubt. Particularly, the COVID-19 pandemic has destabilized the much-talked about world civilization with many nations still under various infection control measures. Globally, the pandemic has resulted in several losses in the areas of jobs, income, government revenues, foreign direct investments, among others. Beyond the incalculable economic losses, the pandemic constitutes a great threat to physical, social and mental health. Since the outbreak of the pandemic, several studies have been conducted on the experiences of different countries to help deepen global knowledge on the pandemic. This review paper chronicles the Ghanaian experience of COVID-19 and attempts to probe whether the country's overall response to the disease is worthy of emulation by other nations. Part one introduces the paper by looking at the intersection of health and development, a brief history of COVID-19, challenges associated with the pandemic and measures some countries have employed to rebuild their economies. Part two describes the key issues underpinning the spread of the virus in Ghana whilst part three considers the efforts key stakeholders employed to contain and manage the spread of the virus. Part four focuses on the challenges Ghana has faced in the management of the pandemic whereas the concluding part presents the core issues which should engage the attention of stakeholders.