Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible

Arashiyama, Takaroni; Kodama, Yasumitsu; Kobayashi, Takanori; Hoshina, Hideyuki; Takagi, Ritsuo; Hayashi, Takafumi; Cheng, Jun-Jack; Saku, Takashi

doi:10.1016/j.oooo.2012.01.018

Cited by 37 publications

(56 citation statements)

References 22 publications

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“…Five patients died of recurrence or distant metastasis 92. It has also been reported that GCOC is more prevalent in Asians (12/18) than in other racial groups 93.…”

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 75%

“…Three GCOC variants are identified according to their pathogenic mechanisms, as follows: 1) GCOC arising de novo is a malignant neoplasm not associated with previous DGCT or CCOT, although sometimes DGCT-like areas may be present;96 2) GCOC ex-CCOT is considered when a GCOC is found to be derived from previously diagnosed CCOT, or when a GCOC is associated with benign CCOT;54,92 and 3) GCOC ex-DGCT is a recurrent malignant neoplasm previously diagnosed as benign DGCT, in which occasional dentin-like material areas are demonstrated 90…”

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 99%

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Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

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“…Five patients died of recurrence or distant metastasis 92. It has also been reported that GCOC is more prevalent in Asians (12/18) than in other racial groups 93.…”

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 75%

Section: Ghost Cell Odontogenic Carcinomamentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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“…GCOC is diagnosed on the basis of atypical histologic features, necrosis, prominent mitoses, infiltrative growth pattern, aggressive behavior, and high expression of Ki-67 and p53 [4]. This malignant odontogenic tumor arises de novo or secondary to its benign counterpart [5]. As previous studies show, the most probable mechanism of GCOC development is malignant transformation in CCOT after multiple recurrences [5, 6].…”

Section: Discussionmentioning

confidence: 99%

“…This malignant odontogenic tumor arises de novo or secondary to its benign counterpart [5]. As previous studies show, the most probable mechanism of GCOC development is malignant transformation in CCOT after multiple recurrences [5, 6]. …”

Section: Discussionmentioning

confidence: 99%

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Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

Mokhtari

Mohsenifar

Ghorbanpour

2013

Case Reports in Pathology

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Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.

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Shear's Cysts of the Oral and Maxillofacial Regions

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Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible

Cited by 37 publications

References 22 publications

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

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