2006
DOI: 10.2460/ajvr.67.1.180
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Ghrelin, an endogenous growth hormone secretagogue with diverse endocrine and nonendocrine effects

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Cited by 6 publications
(4 citation statements)
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References 170 publications
(147 reference statements)
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“…Ghrelin is synthesized and released primarily by endocrine X/A cells in the stomach (Kojima et al, 1999;Bhatti et al, 2006) and plays an important role in the control of GH secretion. Kojima et al (1999) found that ghrelin specifically stimulated GH release, but did not affect other pituitary hormones.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Ghrelin is synthesized and released primarily by endocrine X/A cells in the stomach (Kojima et al, 1999;Bhatti et al, 2006) and plays an important role in the control of GH secretion. Kojima et al (1999) found that ghrelin specifically stimulated GH release, but did not affect other pituitary hormones.…”
Section: Discussionmentioning
confidence: 99%
“…Circulating ghrelin, the endogenous ligand of GH secretagogues-receptor (GHS-R), is synthesized primarily in the stomach in mammals (Bhatti et al, 2006). Ghrelin acts on the GHS-R, increasing intracellular Ca 2+ levels via inositol 1,4,5-trisphosphate (IP3) to stimulate GH release (Kojima and Kangawa, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Ghrelin acts through a receptor separate from the GHRH receptor, called the GH secretagogue receptor (GHS-R), or ghrelin receptor. In humans, GH release after ghrelin administration is more pronounced than after GHRH administration, and the effect is not absolutely specific, because ghrelin also increases the secretion of prolactin, ACTH, and cortisol (Bhatti et al, 2006a). Interestingly, the GHS-R was identified several years before the discovery of its natural ligand ghrelin and was therefore also called "orphan" GHS-R.…”
Section: Regulation Of Growth Hormone Secretion From the Pituitary Glandmentioning
confidence: 99%
“…;Bhatti et al, 2006a;Mol and Meij, 2008; Box 2-1). Simplified, schematic representation of the hypothalamus-pituitary-growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis.…”
mentioning
confidence: 99%