Ghrelin and eating disorders

Abstract

There is growing evidence supporting a multifactorial etiology that includes genetic, neurochemical, and physiological components for eating disorders above and beyond the more conventional theories based on psychological and sociocultural factors. Ghrelin is one of the key gut signals associated with appetite, and the only known circulating hormone that triggers a positive energy balance by stimulating food intake. This review summarizes recent findings and several conflicting reports on ghrelin in eating disorders. Understanding these findings and inconsistencies may help in developing new methods to prevent and treat patients with these disorders.

Taste sensitivity in anorexia nervosa: A systematic review

“…Similarly, although a number of hormones, including leptin, cholecystokinin (CCK), and ghrelin, have been implicated in taste sensitivity, the reviewed studies did not assess hormone levels (Cai et al, 2013; Han, Keast, & Roura, 2017; Yoshida et al, 2017). Significantly, these hormones are known to be altered in AN, suggesting that future research could explore the role of these biological factors in taste sensitivity in this population (Atalayer, Gibson, Konopacka, & Geliebter, 2013; Cuntz et al, 2013; Hebebrand, Muller, Holtkamp, & Herpertz‐Dahlmann, 2006). Therefore, this systematic review highlights the need for controlled experimental designs in future research in taste sensitivity, with consideration for potential confounding variables, to illuminate the conflicting findings of previous research in this area.…”

Effects of endurance training and herb supplementation on tissue nesfatin-1/nucleobindin-2 and ghrelin mRNA expression

“…The enzyme responsible for ghrelin acylation is ghrelin O-acyltransferase (GOAT) belonging to the family of membrane O-acyl transferase [31]. In contrast to nesfatin-1, ghrelin as an orexigenic peptide increase food intake behavior during energy deficiencies status/negative energy balance situations (starvation, fasting, cachexia, malnutrition, weight reduction, calorie restriction, eating disorders) [32][33][34]. In addition, to energy regulation matter, it has been shown that different nutrients manipulation has also impact on ghrelin levels and gene expression [35,36].…”

Hyperghrelinemia in the patients presenting with Prader-Willi syndrome

“…Высокое содержание грелина отмечается при голодании, нервной анорексии, булимии, кахексии -состояниях, характеризующихся нарушением пи-щевого поведения и низким энергетическим стату- сом [32]. В то же время при повышении энергетиче-ского гомеостаза (развитии ожирения, гиперглике-мии, инсулинорезистентности) определяются низ-кие значения грелина [32].…”

“…В то же время при повышении энергетиче-ского гомеостаза (развитии ожирения, гиперглике-мии, инсулинорезистентности) определяются низ-кие значения грелина [32]. Изучение этого орексигенного гормона при СПВ представляет большой интерес, так как причи-на патологического аппетита, а соответственно и этиопатогенетическая терапия синдрома до настоя-щего времени не известны.…”