Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy

Zub-Pokrowiecka, Anna; Rembiasz, Kazimierz; Konturek, Peter C.; Budzyński, Andrzej; Konturek, Stanisław J.; Winiarski, Marek; Bielański, Władysław

doi:10.3748/wjg.v17.i4.449

Cited by 17 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest that ghrelin and des‐acyl ghrelin may play a role in the gastric cancer development and progression. Recent evidence 20,21 have also proved the association between a low serum concentration of ghrelin and the risk of gastric cancer. Therefore, the role of ghrelin in the initiation and progression of gastric cancer needs further study.…”

Section: Discussionmentioning

confidence: 96%

The proliferative effects of ghrelin on human gastric cancer AGS cells

Tian

Fan

2012

J of Digest Diseases

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

The proliferative effects of ghrelin on human gastric cancer AGS cells

Tian

Fan

2012

J of Digest Diseases

View full text Add to dashboard Cite

show abstract

“…Only a few published studies examined relationships between serum ghrelin levels and gastric [15], [22] or esophageal [13], [14] cancer. All of these studies required further investigations in different populations to confirm their findings, and had limitations in sample size.…”

Section: Discussionmentioning

confidence: 99%

Serum Ghrelin; A New Surrogate Marker of Gastric Mucosal Alterations in Upper Gastrointestinal Carcinogenesis

et al. 2013

View full text Add to dashboard Cite

BackgroundA few studies have indicated inverse relationships between serum ghrelin and gastric and esophageal cancers but those associations have been restricted to specific populations, including smokers and overweight individuals. We examined the association between ghrelin and gastroesophageal cancers and atrophic gastritis in a population-based setting.MethodsIn total 220 gastroesophageal cancers, comprising non-cardia and cardia gastric cancer, esophageal adenocarcinoma, esophageal squamous cell carcinoma (SCC) and age and gender-matched controls were recruited. Serum ghrelin, pepsinogen I/II ratio (PGI/II) and anti-H.pylori IgG antibodies were measured. Relationships between ghrelin and gastroesophageal cancers, after adjustment for PGI/II ratio, H.pylori status and smoking, were tested using logistic regression. Furthermore, in 125 endoscopically normal volunteers, with and without histological atrophic gastritis, the relationship with ghrelin was compared.ResultsSerum ghrelin (lowest vs. highest quintile) was inversely associated with gastric cancer: OR (95% CI) 8.71 (1.70–44.59) for cardia and 6.58 (1.26–34.46) for non-cardia cancer. Lower serum ghrelin was also associated with esophageal SCC: OR (95% CI) 5.69 (1.36–23.78), but not with esophageal adenocarcinoma. A similar association was observed between gastric cancer (cardia and non-cardia) and esophageal SCC when serum ghrelin was analysed as a continuous scaled variable. In endoscopically-normal volunteers, extensive atrophic gastritis was associated with low serum ghrelin [OR (95% CI) 0.25 (0.10–0.64)].ConclusionInverse associations between ghrelin and some gastroesophageal cancers suggest a potential role for serum ghrelin as a biomarker of upper gastrointestinal cancers and atrophic gastritis. In areas with a high incidence of gastric and/or esophageal cancer, screening might be more effectively targeted to individuals with low serum ghrelin in addition to the PGI/II ratio.

show abstract

“…Patients with resected gastric cancer experience low plasma ghrelin concentrations. Table 2 lists studies of the change in ghrelin concentration after gastrectomies [31][32][33][34][35][36][37]. In total gastrectomy patients, ghrelin concentrations were immediately reduced to 12-29 % of the preoperative concentration.…”

Section: Gastrectomy and Ghrelin Secretionmentioning

confidence: 99%

Clinical application of ghrelin administration for gastric cancer patients undergoing gastrectomy

et al. 2013

View full text Add to dashboard Cite

Loss of body weight is a common (and the most serious) sequela after gastrectomy. It impairs quality of life, increases various diseases including infection, and may affect long-term survival. Ghrelin, an intrinsic ligand of the growth hormone secretagogue receptor, was discovered in the stomach in 1999. In addition to growth hormone secretion, ghrelin has pleiotropic functions including appetite stimulation, increasing bowel movement and absorption, and anti-inflammatory reactions. In consequence, ghrelin comprehensively leads positive energy balance and weight gain. The fundic gland of the stomach produces the majority of ghrelin, and plasma ghrelin declines to 10-30 % of the preoperative level after total gastrectomy and 50-70 % after distal gastrectomy. Although plasma ghrelin is never restored after total gastrectomy, it gradually recovers to the preoperative level within a few years after distal gastrectomy. Chronic gastritis due to Helicobacter pylori infection and vagotomy are additional factors that perturb the ghrelin secretion of gastric cancer patients after gastrectomy. A randomized clinical trial that revealed that recombinant ghrelin administration successfully increased both food intake and appetite, and ameliorated weight loss after total gastrectomy. Ghrelin administration could thus be a promising strategy to transiently improve the nutritional status of patients who who have undergone gastrectomy, but its effect in the long term remains unclear. Further studies are warranted to elucidate the mechanism of ghrelin and to create and evaluate the analogs that could be administered orally or subcutaneously.

show abstract

Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy

Abstract: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis.

Cited by 17 publications

References 17 publications

The proliferative effects of ghrelin on human gastric cancer AGS cells

The proliferative effects of ghrelin on human gastric cancer AGS cells

Serum Ghrelin; A New Surrogate Marker of Gastric Mucosal Alterations in Upper Gastrointestinal Carcinogenesis

Clinical application of ghrelin administration for gastric cancer patients undergoing gastrectomy

Contact Info

Product

Resources

About