Ghrelin and Metabolic Surgery

Pournaras, Dimitrios J.; Roux, Carel W. le

doi:10.1155/2010/217267

Cited by 41 publications

(25 citation statements)

References 61 publications

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“…In contrast, ghrelin levels have been found to remain unchanged after gastric bypass surgery in several studies (Pournaras & le Roux, 2010;Vincent & le Roux, 2008).…”

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

“…Data regarding the alteration of ghrelin levels following gastric bypass surgery are inconsistent (Higgins et al, 2007;Pournaras & le Roux, 2009;Pournaras & le Roux, 2010;Vincent & le Roux, 2008).…”

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

“…Several explanations have been proposed for the conflicting findings regarding ghrelin levels following gastric bypass surgery including differences in pre-operative insulin resistance, surgical methods and post-operative vagal nerve dysfunction (Pournaras & le Roux, 2010;Vincent & le Roux, 2008).…”

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

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Ghrelin in obesity and endocrine diseases

Scerif

Goldstone

Korbonits

2011

Molecular and Cellular Endocrinology

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“…In contrast, ghrelin levels have been found to remain unchanged after gastric bypass surgery in several studies (Pournaras & le Roux, 2010;Vincent & le Roux, 2008).…”

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

Section: Ghrelin and Bariatric Surgerymentioning

confidence: 99%

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Ghrelin in obesity and endocrine diseases

Scerif

Goldstone

Korbonits

2011

Molecular and Cellular Endocrinology

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“…The single or combined action of these satiating hormones provides a plausible explanation for the decrease in meal size observed in RYGB rats. The blood concentration of ghrelin, in contrast, seems to decrease after RYGB, which theoretically could be associated with a reduced drive to eat; however, data about changes in circulating ghrelin are rather inconsistent [13,21,23,24] and the relevance of changes in ghrelin secretion, if they occur, is also unclear. Further, it is unclear whether the observed changes in ghrelin concentrations observed in some studies are physiologically relevant modulators of eating; finally, ghrelin-deficient mice showed an unaltered body weight-lowering response to the VSG procedure [25] .…”

Section: Rygb Surgery Changes the Concentration Of Circulating Gut Homentioning

confidence: 99%

Physiological Mechanisms behind Roux-en-Y Gastric Bypass Surgery

Lutz¹,

Bueter

2014

Dig Surg

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Obesity and its related comorbidities can be detrimental for the affected individual and challenge public health systems worldwide. Currently, the only available treatment options leading to clinically significant and maintained body weight loss and reduction in obesity-related morbidity and mortality are based on surgical interventions. Apart from the 'gold standard' Roux-en-Y gastric bypass (RYGB), the vertical sleeve gastrectomy and gastric banding are two frequently performed procedures. This review will discuss animal experiments designed to understand the underlying mechanisms of body weight loss after bariatric surgery. While caloric malabsorption and mechanical restriction are no major factors in this respect, alterations in gut hormone levels are invariably found after RYGB. However, their causal role in RYGB effects on eating and body weight has recently been challenged. Other potential factors contributing to the RYGB effects include increased bile acid concentrations and an altered composition of gut microbiota. RYGB is further associated with remarkable changes in the preference for different dietary components such as a decrease in the preference for high fat or sugar; it is important to note that the contribution of altered food preferences to the RYGB effects on body weight is not clear. high fat or sugar; it is important to note that the contribution of altered food preferences to the RYGB effects on body weight is not clear.

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“…One study asked patients to describe the most important problem in their diet, and the answer was the feeling of hunger (24). The feeling of hunger is an important problem to reconcile.…”

Section: Discussionmentioning

confidence: 99%

Effect of Resected Gastric Fundus Fat on Ghrelin Tissue Levels: A Prospective Study

Durmuş¹,

Durmus²,

Abahuni³

et al. 2017

chr

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Introducere: Obezitatea este în prezent o problemă de sănătate importantă, care evoluează rapid la nivel mondial. În ultimii ani numărul intervenţiilor chirurgicale conexe obezităţii a crescut. Cea mai frecventă preocedură chirurgicală a obezităţii este gastrectomia longitudinală laparoscopică (LSG). Scopul acestui studiu a fost compararea expresiei genetice a hormonului gherlin în zone diferite ale stomacului. Material şi metodă: 19 pacienţi obezi supuşi LSG au fost examinaţi în cadul acestui studiu. Grăsimea din două părţi diferite ale stomacului (fundus şi zona superioara a acestuia) a fost analizată prin testul ELISA (enzyme-linked immunosorbent assay). Au fost aplicate tehnici de izolare ARN, ADN complementar şi RQ-PCR (detecţie în timp real: real-time PCR). În plus, un kit de analiză ELISA a fost folosit pentru a măsura cantitatea de gherlin la pacienţii obezi. Au fost comparate statistic nivelele de gherlin din fundus şi zona superioara a acestuia. Rezultate: În cazul tuturor celor 19 pacienţi, nivelul mediu de gherlin a fost mai mare de 30. Nivelul mediu de ghelin a stratului de grăsime localizat în partea superioara a fundusului a fost mai mare de 30 în cazul a 4 pacienţi; nivelul mediu a fost 5 la restul pacienţilor. Am observat o diferenţă statistică semnificativă a nivelului de gherlin între fundus şi stratul de grăsime al acestuia. Concluzie: Recoltarea ţesutului gras din fundus nu este practicată de rutină în timpul LSG. Totuşi, creşterea nivelului de hormon gherlin în acest ţesut necesită prelevarea de ţesut din fundus în timpul intervenţiei chirurgicale.Cuvinte cheie: gastrectomia longitudinală laparoscopică (LSG), nivel de gherlin, ţesut gras gastric, fundus Abstract Introduction: Obesity is currently an important health problem that is rapidly

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Ghrelin and Metabolic Surgery

Cited by 41 publications

References 61 publications

Ghrelin in obesity and endocrine diseases

Ghrelin in obesity and endocrine diseases

Physiological Mechanisms behind Roux-en-Y Gastric Bypass Surgery

Effect of Resected Gastric Fundus Fat on Ghrelin Tissue Levels: A Prospective Study

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