Ghrelin for the management of cachexia associated with cancer

Khatib, Mahalaqua Nazli; Shankar, Anuraj H.; Kirubakaran, Richard; Gaidhane, Abhay; Gaidhane, Shilpa; Simkhada, Padam; Syed, Zahiruddin Quazi

doi:10.1002/14651858.cd012229.pub2

Cited by 27 publications

(27 citation statements)

References 105 publications

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“…16,17 In addition to its beneficial actions on osteogenesis, GHRL has also the ability to inhibit inflammation. 9,24 In the present study, GHRL counteracted the proinflammatory and proteolytic effects of F. nucleatum and IL-1β on the osteoblast-like cells, which concurs with our previous findings in periodontal fibroblasts. 16,17 Both F. nucleatum and IL-1β induced an increase in the expressions of COX2, CCL2, IL-6, IL-8, and MMP1, which stimulate inflammation and thereby bone resorption.…”

Section: Discussionsupporting

confidence: 93%

“…expression, calcium accumulation in the matrix, inhibition of osteoblastic cells apoptosis, and exerts anabolic effect on osseous tissue. 7,[24][25][26] GHRL has a positive relationship with the trabecular bone density. 27 However, the actions of GHRL on osteoclastogenesis are contradictory and it has even been postulated that the physiological effect of ghrelin on osteoclasts may be limited.…”

Section: Discussionmentioning

confidence: 96%

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Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Nokhbehsaim

Nogueira²,

Memmert

et al. 2019

Braz. oral res.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Nokhbehsaim

Nogueira²,

Memmert

et al. 2019

Braz. oral res.

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“…Elevated serum ghrelin levels in patients with malignant disease are usually explained by weight loss and cachexia. 20 In our study, we showed a significant correlation between body weight and the concentration of total and acylated ghrelin in all patients, just as in the general population. Nonetheless, it should be noted that in the ACC group, we did not observe significant changes in body weight during treatment.…”

Section: Methodssupporting

confidence: 68%

“…Nevertheless, the evidence is not sufficient to support or contradict the use of ghrelin in those patients. 20 In this context, it seems reasonable to evaluate the levels of both plasma ghrelin forms. Perhaps the assessment of the ratio of acylated to total ghrelin or acylated to nonacylated ghrelin might be a more useful tool with regard to clinical outcomes.…”

Section: Methodsmentioning

confidence: 99%

Changes in total and acylated ghrelin in patients with adrenocortical carcinoma during mitotane treatment

Komarowska

Ruciński

Fichna

et al. 2019

Polish Archives of Internal Medicine

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INTRODUCTION Adrenocortical carcinoma (ACC) is a highly aggressive cancer with poor prognosis. Mitotane is the only approved drug for ACC treatment. Tolerability and efficacy of mitotane is variable. There is evidence that ghrelin may affect cancer development and the occurrence of side effects. OBJECTIVES We examined the differences in plasma ghrelin concentrations between patients with benign adrenal tumors and adrenal carcinoma. We also investigated the effect of mitotane treatment on circulating plasma ghrelin levels in patients with ACC. Additionally, we assessed the relationship between ghrelin concentrations, mitotane levels, and side effects of mitotane treatment. PATIENTS AND METHODS We enrolled 26 patients with ACC and 42 controls with adrenocortical adenoma (ACA). Clinical and histopathologic features, hormonal secretion pattern, and plasma acylated and total ghrelin levels were measured in every patient. Serum mitotane levels, body mass index, and side effects of mitotane treatment were estimated every 3 to 12 weeks during follow-up in patients with ACC. RESULTS There was no significant difference in total and acylated ghrelin concentrations between ACC and ACA groups before mitotane introduction in ACC. We observed that during mitotane treatment, both total and acylated ghrelin levels became elevated in ACC compared with ACA. A positive correlation was found between circulating mitotane levels and acylated ghrelin as well as the ratio of acylated to total ghrelin levels in all patients treated with mitotane. Higher ghrelin levels were associated with increased risk of side effects. CONCLUSIONS Plasma ghrelin levels are changed during mitotane treatment. These changes may be connected with side effects of mitotane.

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“…Among the hormonal factors, releasing hormone (GHRH) promotes the synthesis and release of GH [1], while somatostatin (SS) inhibits its release, but not synthesis [2]. Ghrelin hormone also induces GH release by direct action on the pituitary gland [3,4], by stimulating the release of GHRH [5,6,7] and antagonize the effects of somatostatin [8,9].…”

Section: Introductionmentioning

confidence: 99%

Efeito da ghrelina sobre o eixo GH/IGF-1 em animais submetidos à endotoxemia

Faim¹

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À minha orientadora Profª. Drª. Evelin Capellari Cárnio por acreditar em mim e sempre torcer pelo meu sucesso. Por todos momentos que passamos, pelas oportunidades únicas que me concedeu, pelos ensinamentos, ao longo de toda pós-graduação, e pela grande amizade que desenvolvemos. Aos professores que aceitaram participar da minha banca de defesa do doutorado. À Profª. Drª. Angelita Maria Stabile por colaborar com meu trabalho ao realizar, me ensinar e discutir os resultados dos experimentos de Western Blott. Por toda nossa amizade e companheirismo. Ao Prof. Dr. Riccardo Lacchini por colaborar com meu trabalho ao realizar, me explicar e discutir meus resultados dos experimentos de PCR-RT. Aos Professores Dr. José-Antunes Rodrigues e Drª. Lucila Leico K. Elias, pelas dosagens de corticosterona realizada em seu laboratório. À Msc. Patrícia Passaglia por me ajudar durante todo o trabalho, discutindo, ensinando, sugerindo, corrigindo, participando ativamente dos experimentos e agregando valor à minha tese. Ao Msc. e especialista de laboratório Marcelo Eduardo Batalhão pela dosagem de nitrato e por todos os anos de companheirismo, ensinamentos e ajuda. Ao meu Prof. de graduação, Dr. Henry Maia Peixoto, por ser um exemplo de profissional que levo comigo até hoje. Aos meus outros colegas de laboratório, André e Aline, por todos os bons momentos que compartilhamos. Aos meus amigos e familiares de longas datas por fazerem parte da minha história.

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Ghrelin for the management of cachexia associated with cancer

Cited by 27 publications

References 105 publications

Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Changes in total and acylated ghrelin in patients with adrenocortical carcinoma during mitotane treatment

Efeito da ghrelina sobre o eixo GH/IGF-1 em animais submetidos à endotoxemia

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