Ghrelin in the heart and growth hormone: which is chicken, which is egg?

Pecker, Françoise

doi:10.1016/j.cardiores.2004.03.013

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…In the present study, we documented endogenous production of Ghr in the RV, lung, and gastric fundus, which is consistent with previous reports showing production of Ghr in these organs (14,17,25). Such production was inhibited by exogenous administration of Ghr in healthy animals, suggesting that systemic levels of Ghr might regulate its local production.…”

Section: Discussionsupporting

confidence: 93%

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension

Henriques‐Coelho¹,

Correia‐Pinto²,

Roncon‐Albuquerque³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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-Moreira. Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 287: H2885-H2890, 2004; doi:10.1152/ ajpheart.01122.2003.-We investigated the endogenous production of ghrelin as well as cardiac and pulmonary vascular effects of its administration in a rat model of monocrotaline (MCT)-induced pulmonary hypertension (PH). Adult Wistar rats randomly received a subcutaneous injection of MCT (60 mg/kg) or an equal volume of vehicle. One week later, animals were randomly assigned to receive a subcutaneous injection of ghrelin (100 g/kg bid for 2 wk) or saline. Four groups were analyzed: normal rats treated with ghrelin (n ϭ 7), normal rats injected with saline (n ϭ 7), MCT rats treated with ghrelin (n ϭ 9), and MCT rats injected with saline (n ϭ 9). At 22-25 days, right (RV) and left ventricular (LV) pressures were measured, heart and lungs were weighted, and samples were collected for histological and molecular analysis. Endogenous production of ghrelin was almost abolished in normal rats treated with ghrelin. In MCT-treated animals, pulmonary expression of ghrelin was preserved, and RV myocardial expression was increased more than 20 times. In these animals, exogenous administration of ghrelin attenuated PH, RV hypertrophy, wall thickening of peripheral pulmonary arteries, and RV diastolic disturbances and ameliorated LV dysfunction, without affecting its endogenous production. In conclusion, decreased tissular expression of ghrelin in healthy animals but not in PH animals suggests a negative feedback in the former that is lost in the latter. A selective increase of ghrelin mRNA levels in the RV of animals with PH might indicate distinct regulation of its cardiac expression. Finally, ghrelin administration attenuated MCT-induced PH, pulmonary vascular remodeling, and RV hypertrophy, indicating that it may modulate PH. myocardial hypertrophy; ventricular hemodymamics; pulmonary vasculature PULMONARY HYPERTENSION (PH) is a progressive disease associated with right ventricular (RV) hypertrophy that commonly progresses to heart failure. Endothelin (ET)-1 and several other neurohumoral agents play a central role in the complex pathophysiology of PH (11,28) and are used as therapeutic targets for this entity. For instance, several authors observed that ET-1 antagonism decreases PH, restores endothelial metabolic function, inhibits RV hypertrophy, and improves survival both in experimental (5,19,26) and clinical (27) settings.

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Section: Discussionsupporting

confidence: 93%

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension

Henriques‐Coelho¹,

Correia‐Pinto²,

Roncon‐Albuquerque³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…An alternative approach for increasing systemic levels GH, possibly in a more physiological manner, is the administration of GHS [38], of which ghrelin is the endogenous representative [39]. Ghrelin, a 28-amino acid peptide n-octanoylated at serine 3, exerts its neuroendocrine effects through stimulating 7 transmembrane G proteincoupled receptors (GHS-R1a) [39].…”

Section: Effects Of Ghs In Cardiac Cachexia and Heart Failurementioning

confidence: 99%

Cardiac and peripheral actions of growth hormone and its releasing peptides: Relevance for the treatment of cardiomyopathies

Marleau

Mulumba

Lamontagne

et al. 2006

Cardiovascular Research

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Ischemic and nonischemic cardiomyopathies are associated with significant morbidity and mortality in industrialized countries. Cardiomyopathies of primary origin, and more specifically the dilated form of the disease, have been associated with a number of gene defects in cytoskeletal, membrane, and sarcomeric proteins. Cardiomyopathies of secondary origin such as ischemic cardiomyopathy remain the leading cause of left ventricular systolic dysfunction and heart failure. Among novel strategies to improve cardiac function in heart failure, treatment with growth hormone, insulin growth factor-1 (IGF-1), and natural and synthetic growth hormone-releasing peptides such as ghrelin and hexarelin have been explored. The present review focuses on the issues involved in the use of exogenous growth hormone and its releasing peptides in experimental animal models of chronic heart failure and in clinical studies on cardiomyopathic patients as potential releasing peptides for the treatment of chronic heart failure developing as a consequence of cardiomyopathy.

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“…This ligand, which mainly expresses in mammal stomach and can specifically stimulate pituitary for releasing growth hormone (GH), has a strong effect on function and metabolism of stomach, gut and heart (Kojima et al, 1999;Ahmed et al, 2002;Noritoshi et al, 2003). This hormone increases food intake and accelerates growth rate (Guido et al, 2002;Iglesias et al, 2004;Pecker et al, 2004). Kaiya et al (2001) cloned chicken ghrelin gene.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of Ghrelin Gene in Twelve Chinese Indigenous Chicken Breeds and Its Relationship with Chicken Growth Traits

Li¹,

Li²,

Li³

et al. 2005

Asian Australas. J. Anim. Sci

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A 2,656 bp fragment of chicken ghrelin gene was cloned and SNPs were detected by PCR-RFLP and Allele Specific PCR (ASP) in 12 Chinese indigenous chicken breeds and a commercial chicken population. The results showed that there were 23 base variations and an amino acid change (Gln→Arg) in cloned chicken ghrelin gene. Three SNPs were confirmed in 13 populations and associations between this gene and growth traits of Tibetan chicken (TC) and Recessive White chicken (RW) were investigated. The results of haplotype analysis revealed that 26 haplotype genotypes were composed of eight haplotypes. The results of x 2 tests indicated that there were significant differences between genotypes or haplotype genotype frequencies in some of the breeds or sexes at 0.05 or 0.01 levels. The results of ANOVA revealed that there were significant differences between genotypes or haplotype genotypes on some growth traits of TC and RW chicken breeds at 0.05 or 0.01 levels. Multiple comparisons showed that there were significant associations between genotype CT at site 71 and some growth traits of two chicken breeds and between genotype AG at site 1,215 and body weight at 16 wk of two chicken breeds, and there was a significant association between haplotype genotype CAA/CAG and body weight and shank girth at 16 wk of two chicken breeds.

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Ghrelin in the heart and growth hormone: which is chicken, which is egg?

Cited by 5 publications

References 18 publications

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension

Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension

Cardiac and peripheral actions of growth hormone and its releasing peptides: Relevance for the treatment of cardiomyopathies

Polymorphism of Ghrelin Gene in Twelve Chinese Indigenous Chicken Breeds and Its Relationship with Chicken Growth Traits

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