Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus Roux-en-Y gastric bypass—results of a randomized clinical trial

Kalinowski, Piotr; Paluszkiewicz, Rafał; Wróblewski, Tadeusz; Remiszewski, Piotr; Grodzicki, Mariusz; Bartoszewicz, Zbigniew; Krawczyk, Marek

doi:10.1016/j.soard.2016.08.025

Cited by 115 publications

(100 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We also observed changes in the VAT metabolic gene profile with an upregulation of EHHADH -a peroxisomal enzyme responsible for beta oxidation of fatty acids -and related processes of fatty acid betaoxidation, peroxisome function, and amino acid metabolism. In keeping with the published human data showing decreased systemic and organ-specific leptin levels following sleeve gastrectomy, there was a reduction in the leptin (LEP) expression within the VAT of SG animals [29][30][31]. There was also a reduction in oxytocin receptor signaling, which partially controls adipogenesis and fat accumulation in fat-tissue depots [32].…”

Section: Rna Sequencing Reveals Gene Level Changes In Visceral Fat Imsupporting

confidence: 81%

Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss

Harris

Mina

Čabarkapa

et al. 2019

Preprint

View full text Add to dashboard Cite

Objective: Sleeve gastrectomy (SG) induces weight-loss independent improvements in glucose homeostasis by unknown mechanisms. We sought to identify the metabolic adaptations responsible for these improvements.Methods: Non-obese C57Bl6/J mice on standard chow underwent SG or sham surgery. Functional testing and indirect calorimetry were used to capture metabolic phenotypes. Tissuespecific glucose uptake was assessed by 18-FDG PET/CT and RNA sequencing was used for gene expression analysis.Results: In this model, SG induced durable improvements in glucose tolerance despite not causing lasting changes in weight, fat/lean mass, or food intake. Indirect calorimetry revealed post-SG animals had respiratory exchange ratios (RER) nearing 1.0 on average and had daily RER excursions above 1.0, indicating preferential glucose utilization and increased energy demand, respectively. Sham operated mice demonstrate normal RER feeding/fasting excursions. PET/CT showed increased avidity within white adipose depots. Finally, SG led to an upregulation in the transcriptional pathways involved in energy metabolism, adipocyte maturation, and adaptive and innate immune cell chemotaxis and differentiation within the visceral adipose tissue.Conclusions: SG induces a rapid, weight-loss independent shift towards glucose utilization and transcriptional remodeling of metabolic and immune pathways in visceral adipose tissue.

show abstract

Section: Rna Sequencing Reveals Gene Level Changes In Visceral Fat Imsupporting

confidence: 81%

Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss

Harris

Mina

Čabarkapa

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Of the 25 studies that were full‐text screened, 13 did not meet the inclusion criteria either because follow‐up time was too short, the authors did not differentiate between improvement and remission of T2DM, other bariatric procedures were performed (mini gastric bypass, banded RYGB, and metabolic gastric bypass), the study was not an RCT, no patients in the SG‐group had T2DM, or the study included a subpopulation of an already included RCT . We detected two studies that had been performed in the same study population, and of these, only the study referring to a clinical trial registry number was included . Finally, 12 articles of 10 different RCTs, where of four had data on remission at different lengths of follow‐up, were included in the systematic review.…”

Section: Resultsmentioning

confidence: 99%

“…We detected two studies that had been performed in the same study population, and of these, only the study referring to a clinical trial registry number was included . Finally, 12 articles of 10 different RCTs, where of four had data on remission at different lengths of follow‐up, were included in the systematic review.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the effect of Roux‐en‐Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

et al. 2020

View full text Add to dashboard Cite

Bariatric surgery is an effective treatment option for patients with type 2 diabetes mellitus (T2DM) and obesity. This study aims to compare the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on remission of T2DM. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials weresearched for studies published between database inception and 21 November 2019.A meta-analysis, using a random effects model, was performed to calculate relative risk (RR) of T2DM remission between the groups in randomized controlled trials (RCTs). Of 2650 records identified, 12 records from 10 different RCTs were finally included. The studies comprised 705 patients with follow-up from 1 to 5 years. The remission rate of T2DM at 1 year was higher among those undergoing RYGB (156/276, 57%) compared with those undergoing SG (128/275, 47%), RR (95% CI) 1.20 (1.00-1.45), P = .047, I 2 = 24.9%, moderate-quality evidence. Among studies with 2-to 5-year follow-up, there was no difference in remission rates between the RYGB (132/263, 50%) and SG (121/266, 46%) groups, RR 1.06 (0.94-1.20), P = .34, I 2 = 0.0%, low-quality evidence. RYGB resulted in a higher rate of T2DM remission compared with SG after 1 year. The T2DM remission rates did not differ in studies with 2-to 5-year follow-up. K E Y W O R D SRoux-en-Y gastric bypass, sleeve gastrectomy, systematic review, type 2 diabetes mellitus Abbreviations: BMI, body mass index; CI, confidence interval; RCT, randomized controlled trial; RR, relative risk; RYGB, Roux-en-Y gastric bypass; SD, standard deviation; SG, sleeve gastrectomy; T2DM, type 2 diabetes mellitus.

show abstract

“…Our review showed that leptin level has the tendency to decrease after different types of bariatric operations [88][89][90][91].…”

Section: Resultsmentioning

confidence: 82%

“…A number of long-term studies have shown that in RYGB and LSG operations a comparable reduction in patient body weight occurs, but the ghrelin level increases in RYGB and decreases in LSG. Therefore, the level of ghrelin does not affect weight loss [88,90,91]. Surgery-mediated modulation of brain function via modified postoperative secretion of gut peptides and vagal nerve stimulation was identified as an underlying mechanism in weight loss and improvement of weight-related diseases.…”

Section: Resultsmentioning

confidence: 99%

The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review

Nykonenko

Haidarzhi

Nykonenko

et al. 2018

ZMJ

View full text Add to dashboard Cite

Ghrelin, leptin, and glycemic control after sleeve gastrectomy versus Roux-en-Y gastric bypass—results of a randomized clinical trial

Cited by 115 publications

References 28 publications

Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss

Sleeve Gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss

Comparison of the effect of Roux‐en‐Y gastric bypass and sleeve gastrectomy on remission of type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review

Contact Info

Product

Resources

About