Ghrelin ligand-receptor mRNA expression in hypothalamus, proventriculus and liver of chicken (Gallus gallus domesticus): Studies on ontogeny and feeding condition

Chen, Li-Long; Jiang, Qingyan; Zhu, Xiaotong; Shu, Gang; Bin, Yan-Fang; Wang, Xiu-Qi; Gao, Ping; Zhang, Yongliang

doi:10.1016/j.cbpa.2007.02.017

Cited by 30 publications

(13 citation statements)

References 53 publications

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“…an increase of ghrelin mRNA expression levels in goldfish, zebrafish, and Atlantic salmon (Unniappan et al, 2004;Amole and Unniappan, 2009;Murashita et al, 2009). Our observation that the mRNA expression levels of GHS-R showed the same trend as ghrelin after food deprivation agrees with the results of the previous studies conducted in rats (Kim et al, 2003), chicken (Chen et al, 2007;Sirotkin et al, 2013) and black seabream (Zhang et al, 2008). However, the current results do not support that this is the case in rainbow trout (Jönsson et al, 2007).…”

Section: Discussionsupporting

confidence: 67%

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Cai

Yuan

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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Section: Discussionsupporting

confidence: 67%

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Cai

Yuan

et al. 2015

Comparative Biochemistry and Physiology Part A: Molecular &

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“…As indicated above, the orexigenic and metabolic activity of acylated ghrelin are purported to be exerted centrally via GHSR-1a, which has wide expression throughout the hypothalamus in teleosts, mammals, and avians (Chen et al, 2007; Sanchez-Bretano et al, 2015; Zigman et al, 2006). For example, in teleosts and mammals, ghrelin stimulates food intake via neuropeptide Y (NPY)/agouti related peptide (AgRP) immunoreactive neurons in the arcuate nucleus (ArcN) (Chen et al, 2017; Delgado et al, 2017; Guan et al, 2008; Kohno et al, 2003; van den Top et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Exendin-4 antagonizes the metabolic action of acylated ghrelinergic signaling in the hypothalamic paraventricular nucleus

Abtahi

Howell

Salvucci

et al. 2019

General and Comparative Endocrinology

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In the current study we investigated the interaction of hypothalamic paraventricular nucleus (PVN) glucagon-like peptide-1 (GLP-1) and ghrelin signaling in the control of metabolic function. We first demonstrated that acylated ghrelin injected directly into the PVN reliably altered the respiratory exchange ratio (RER) of adult male Sprague Dawley rats. All testing was carried out during the initial 2 h of the nocturnal cycle using an indirect open circuit calorimeter. Results indicated that acylated ghrelin induced a robust increase in RER representing a shift toward enhanced carbohydrate oxidation and reduced lipid utilization. In contrast, treatment with comparable dosing of des-acyl ghrelin failed to significantly impact metabolic activity. In separate groups of rats we subsequently investigated the ability of exendin-4 (Ex-4), a GLP-1 analogue, to alter acylated ghrelin’s metabolic effects. Rodents were treated with either systemic or direct PVN Ex-4 followed by acyl ghrelin microinjection. While our results showed that both systemic and PVN administration of Ex-4 significantly reduced RER, importantly, Ex-4 pretreatment itself reliably inhibited the impact of ghrelin on RER. Overall, these findings provide increasingly compelling evidence that GLP-1 and ghrelin signaling interact in the neural control of metabolic function within the PVN.

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“…However, leptin's regulation of RFRP neurons appears to occur via indirect signaling (Rizwan et al 2014). MCH and orexin neurons are also implicated in the mechanism whereby low energy availability suppresses GNRH drive (Chen et al 2007, Backholer et al 2009, Skrapits et al 2015, yet, the influence of NPY/AgRP in the suppression of reproductive function appears to be more critically involved (Wu et al 2012). Nevertheless, the influence of these 'lesser involved' populations should not be ignored as under normal physiological conditions, they still contribute to the net impact of all the inhibitory and stimulatory inputs from the GNRH neuronal network that ultimately regulate GNRH drive.…”

Section: Other Neuronal Populationsmentioning

confidence: 99%

Neuroendocrine integration of nutritional signals on reproduction

Evans

Anderson

2017

Journal of Molecular Endocrinology

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Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that drive reproductive function. The metabolically relevant hormones leptin, insulin and ghrelin have been identified as key mediators of this 'metabolic control of fertility'. However, the neural circuitry through which they act to exert their control over GNRH drive remains incompletely understood. With the advent of Cre-LoxP technology, it has become possible to perform targeted gene-deletion and gene-rescue experiments and thus test the functional requirement and sufficiency, respectively, of discrete hormone-neuron signaling pathways in the metabolic control of reproductive function. This review discusses the findings from these investigations, and attempts to put them in context with what is known from clinical situations and wild-type animal models. What emerges from this discussion is clear evidence that the integration of nutritional signals on reproduction is complex and highly redundant, and therefore, surprisingly difficult to perturb. Consequently, the deletion of individual hormone-neuron signaling pathways often fails to cause reproductive phenotypes, despite strong evidence that the targeted pathway plays a role under normal physiological conditions. Although transgenic studies rarely reveal a critical role for discrete signaling pathways, they nevertheless prove to be a good strategy for identifying whether a targeted pathway is absolutely required, critically involved, sufficient or dispensable in the metabolic control of fertility.

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Ghrelin ligand-receptor mRNA expression in hypothalamus, proventriculus and liver of chicken (Gallus gallus domesticus): Studies on ontogeny and feeding condition

Cited by 30 publications

References 53 publications

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Sequence, genomic organization and expression of ghrelin receptor in grass carp, Ctenopharyngodon idellus

Exendin-4 antagonizes the metabolic action of acylated ghrelinergic signaling in the hypothalamic paraventricular nucleus

Neuroendocrine integration of nutritional signals on reproduction

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