Ghrelin modulates fatty acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks

Buyse, Johan; Janssen, Sara; Geelissen, Sofie; Swennen, Quirine; Kaiya, Hiroyuki; Darras, Veerle; Dridi, Sami

doi:10.1016/j.peptides.2009.04.015

Cited by 54 publications

(35 citation statements)

References 26 publications

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“…However, the results obtained from earlier studies argued that the administration of exogenous ghrelin can inhibit feed intake (Geelissen et al, 2006;Buyse et al, 2009;Ocłón and Pietras, 2011;Lotfi et al, 2013). The impact of GHS-R antagonist on chicken feed intake, which is regarded as a research gap, was addressed by Asakawa et al (2003), who found that the acute (high level) and central (intracerebroventricular) infusion of ghrelin receptor antagonist reduces food intake and body weight gain in laboratory mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Shahryar

Lotfi

2016

Arch. Anim. Breed.

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Abstract. In the present study, possible effects of peripheral administration of ghrelin antagonist [D-Lys 3 ]-GHRP-6 on chicken performance, thyroid hormones level and serum biochemical parameters were investigated. Broiler chicks divided into five experimental groups were reared up to day 42. On day 21, a treatment was assigned to the five groups: group 1 (control), chickens without any administration of peptide or solution; group 2 (G50), chickens with intraperitoneal (IP) injection of 50 ng per 100 g body weight (BW) of D-Lys 3 peptide on day 21; group 3 (G100), chickens with IP injection of 100 ng per 100 g BW of D-Lys 3 peptide on day 21; group 4 (G150), chickens with IP injection of 150 ng per 100 g BW of D-Lys 3 peptide on day 21; and group 5 (G200), chickens with IP injection of 200 ng per 100 g BW of D-Lys 3 peptide on day 21. On days 21 (post-injection) and 42 (post-rearing), blood samples were obtained from the animals for laboratory analyses. Experimental groups administered the GHS-R antagonist showed less feed intake -i.e., administration of greater doses led to less feed intake (P < 0.01). Daily weight gains within groups G150 and G200 decreased (P < 0.01) in comparison with the control. The feed conversion ratio (FCR) did not differ among the groups. There was a significant difference between control and experimental groups for glucose, total cholesterol and phosphorus levels (P < 0.01) in postinjection samples. In post-injection and post-rearing blood samples, the thyroid hormone (T 3 and T 4 ) in 6 h increased in treated groups in comparison with the control (P < 0.01). The infusion of ghrelin antagonist [DLys 3 ]-GHRP-6 reduces feed intake and body weight. With regard to increase in T 4 level, it can be inferred that [D-Lys 3 ]-GHRP-6 may increase metabolic rate, lipolysis and weight loss, which is similar to results obtained in mammalian species.

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Section: Discussionmentioning

confidence: 99%

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Shahryar

Lotfi

2016

Arch. Anim. Breed.

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“…In vivo and in vitro investigations showed that GH-releasing action of ghrelin has a dose-depended manner and is similar to growth hormone releasing hormone (GHRH) with a stimulatory effect on somatotrophs in chicken [4] . Regarding metabolic aspects of chicken ghrelin, anti-lipogenic effect of administrated ghrelin in neonatal broiler chicks has been reported by Buyse et al [5] .…”

Section: Introductionmentioning

confidence: 93%

Effect of in ovo Ghrelin Administration on Thyroid Hormones and Some of Serum Biochemical Parameters in Newly-hatched Chicks

Shahryar¹,

Lotfi²

2013

Kafkas Univ Vet Fak Derg

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The aim of this study was to investigate the effect of in ovo ghrelin administration on serum thyroid hormones levels and serum total cholesterol, triglyceride, calcium (Ca), phosphate (P) concentrations and alkaline phosphatase (ALP) activity in newly-hatched chicks. Fertilized eggs were divided into 5 groups; group G1 as control (intact or without injection), group G2 (50 ng ghrelin/egg at day 5), group G3 (100 ng ghrelin/egg at day 5), group G4 (50 ng ghrelin/egg at day 10), and group G5 (100 ng ghrelin/egg at day 10). Data obtained from serum analysis showed that 100ng/egg ghrelin administration caused T 4 elevation, whereas there were no any significant changes when ghrelin was administrated in 50ng/ egg dosage. There was no any significant difference for T 3 level between experimental groups. Serum triglyceride concentration was lower in all injected groups than control group, but only the differences between control group and G2 and G4 groups were statistically significant (P<0.01). Serum Ca concentration was higher in G2 and G3 compared with control group. No significant differences were observed in total cholesterol, P concentrations and ALP activity among experimental groups. The present results indicate that appropriate timing of in ovo injection of ghrelin has considerable effects on serum Ca levels of newly-hatched chicks. Also, higher dosage of in ovo administrated ghrelin can elevate serum T 4 level. Keywords: Chicken, Ghrelin, in ovo administration, Thyroid hormones, Serum biochemical measures Yumurtadan Yeni Çıkmış Civcivlerin Tiroid Hormonları ile Bazı Serum Biyokimyasal Değerleri Üzerine in ovo Ghrelin Enjeksiyonunun Etkisi ÖzetBu çalışmanın amacı; yumurtadan yeni çıkmış civcivlerde in ovo ghrelin uygulamasının serum tiroid hormonları seviyeleri ile serum total kolesterol, trigliserid, kalsiyum, fosfat konsantrasyonları ve alkalin fosfataz (ALP) aktivitesindeki etkilerinin araştırılmasıdır. Döllenmiş yumurtalar G1-G5 olmak üzere 5 gruba ayrıldılar; G1: kontrol (enjeksiyon uygulanmayan), G2: 5. günde 50 ng ghrelin/ yumurta enjeksiyonu, G3: 5. günde 100 ng ghrelin/yumurta enjeksiyonu, G4: 10. günde 50 ng ghrelin/yumurta enjeksiyonu, G5: 10. günde 100 ng ghrelin/yumurta enjeksiyonu. Serum analiz sonuçları 100 ng ghrelin/yumurta uygulamasının T 4 seviyesinde artışa neden olurken 50 ng ghrelin/yumurta uygulamasının herhangi bir değişikliğe neden olmadığını gösterdi. Deneme grupları arasında T 3 seviyesi bakımından herhangi bir değişikliğe rastlanmadı. Serum trigliserid konsantrasyonu kontrol grubu ile kıyaslandığında enjeksiyon uygulanan tüm gruplarda daha düşük olarak tespit edilmesine rağmen sadece G2 ve G4 grupları istatistiksel olarak fark göstermekteydi (P<0.01). Kontrol ile kıyaslandığında, G2 ve G3 gruplarında serum Ca konsantrasyonu daha yüksek olarak belirlendi. Total kolesterol, fosfat konsantrasyonu ve ALP aktivitesi yönünden deney grupları arasında bir fark gözlemlenmedi. Bu sonuçlar uygun zamanda in ovo ghrelin uygulamasının yumurtadan yeni çıkmış civcivlerde serum Ca miktarında önemli...

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“…Lipogenesis in the chicken liver is increased by ghrelin as indicated by expression of fatty acid synthase (Buyse et al, 2009). Moreover, ghrelin reduces the respiratory quotient in young chickens (Geelissen et al, 2006).…”

Section: Ghrelin and Metabolismmentioning

confidence: 99%

Hormones and Metabolism in Poultry

Scanes¹

2011

Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproduction

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Ghrelin modulates fatty acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks

Cited by 54 publications

References 26 publications

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Effect of in ovo Ghrelin Administration on Thyroid Hormones and Some of Serum Biochemical Parameters in Newly-hatched Chicks

Hormones and Metabolism in Poultry

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Ghrelin modulates fatty acid synthase and related transcription factor mRNA levels in a tissue-specific manner in neonatal broiler chicks

Cited by 54 publications

References 26 publications

Effects of peripheral administration of ghrelin antagonist [D-Lys&lt;sup&gt;3&lt;/sup&gt;]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Effects of peripheral administration of ghrelin antagonist [D-Lys&lt;sup&gt;3&lt;/sup&gt;]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Effect of in ovo Ghrelin Administration on Thyroid Hormones and Some of Serum Biochemical Parameters in Newly-hatched Chicks

Hormones and Metabolism in Poultry

Contact Info

Product

Resources

About

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens

Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens