2012
DOI: 10.1016/j.biopsych.2012.03.010
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Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

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Cited by 218 publications
(195 citation statements)
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References 51 publications
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“…In-cage fighting is common among male mice (10), but initially there was no obvious mechanism to explain why BChE should reduce such behavior. Further study, however, implicated enhanced metabolism of ghrelin, which is known for involvement in stress and anxiety (3,11,12).…”
mentioning
confidence: 99%
“…In-cage fighting is common among male mice (10), but initially there was no obvious mechanism to explain why BChE should reduce such behavior. Further study, however, implicated enhanced metabolism of ghrelin, which is known for involvement in stress and anxiety (3,11,12).…”
mentioning
confidence: 99%
“…Although other ghrelin gene-derived products such as UAG and obestatin do not seem to exert any significant effect on the modulation of ACTH production and/or secretion (Yamamoto et al 2007), the ghrelin gene plays a crucial role in the regulation of the stress response. Indeed, ACTH levels were significantly lower in ghrelin KO mice in response to stress, suggesting that some endogenous ghrelin genederived products, probably AG, modulate the response to acute stress, controlling the hypothalamic-pituitary-axis and diminishing anxious behavior under stress (Spencer et al 2012).…”
Section: Observations)mentioning
confidence: 99%
“…Conversely, mice show less anxiety and depressive-like behaviors following caloric restriction or subcutaneous ghrelin injection [Lutter et al 2008], suggesting that elevated plasma ghrelin may have anxiolytic and antidepressant-like effects. Moreover, ghrelin-lacking mice (ghr -/-) show more anxiety-like behaviors in the elevated plus maze and open field tests than wild-type control animals [Spencer et al 2012], and furthermore, these ghr -/-mice secrete less ACTH than wild-type mice, suggesting a mechanism by which ghrelin modulates HPA axis activity (i.e. regulating anterior pituitary release of ACTH), an effect which also impacts on anxiety-like behaviors [Spencer et al 2012].…”
Section: The Hypothalamus-pituitary-adrenal Axismentioning
confidence: 99%
“…Moreover, ghrelin-lacking mice (ghr -/-) show more anxiety-like behaviors in the elevated plus maze and open field tests than wild-type control animals [Spencer et al 2012], and furthermore, these ghr -/-mice secrete less ACTH than wild-type mice, suggesting a mechanism by which ghrelin modulates HPA axis activity (i.e. regulating anterior pituitary release of ACTH), an effect which also impacts on anxiety-like behaviors [Spencer et al 2012].…”
Section: The Hypothalamus-pituitary-adrenal Axismentioning
confidence: 99%