Ghrelin, Resistin and Leptin Levels in Patients with Metabolic Syndrome

Abstract

Aim:This study was designed to compare the fasting ghrelin, leptin and resistin levels between metabolic syndrome (MS) patients with healthy controls. Method:This trial was performed on 21 patients with MS (7 men; mean age, 44±4 years) and 17 healthy controls (8 men; mean age, 43±3 years). Diagnosis of MS was defined based on National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria. Patients meeting at least 3 of the MS criteria, with a body mass index (BMI) ≥30 kg/m² were included in the MS group. Among healthy volunteers, those with a BMI<30 kg/m² were selected as the control group. Plasma ghrelin, serum leptin and resistin concentrations were measured by ELISA method. Result: Ghrelin levels were similar between MS and control groups.There was a negative correlation detected between ghrelin levels with BMI and leptin levels (r=-.54, P=.01 and r=-.56, P=.009, respectively). Resistin levels were found similar between MS with control groups. Leptin levels were significantly higher at the MS group than control group (35±17 ng/ml vs. 14±8 ng/ml, P=.001). Leptin levels had a positive correlation with BMI (r=.56; P=.008). Conclusion:We have demonstrated that leptin levels in MS group were higher than control group. However, ghrelin and resistin levels were similar to control group. In addition, we have showed leptin levels has a positive correlation with BMI and a negative correlation with ghrelin levels.

Assessment of serum chemerin level in an Iranian population with metabolic syndrome and healthy individuals in 2016

“…The lack of relationship between serum chemerin level and insulin resistance may be due to the presence of different hormones which play a role in insulin resistance. The insulin resistance effect of chemerin is insignificant in comparison to these hormones (15). The present results suggest that no significant relationship exists between serum chemerin level and triglyceride, LDL, and HDL.…”

“…The minimum difference in mean serum chemerin level in the two groups which was clinically significant was 22 (n Case = n Control ≈ 22). The exclusion criteria consisted of presence of CVD, acute pulmonary disease, hepatitis B and C, Cushing's syndrome, polycystic ovary syndrome (PCOS), and HIV/AIDS, and use of lipid-lowering drugs, glucocorticoids (GCs), and antipsychotics (15,16). Metabolic syndrome was diagnosed based on the National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATP III).…”

Increased hip circumference in individuals with metabolic syndrome affects serum nesfatin-1 levels

“…At present, obesity, a public health problem, affecting more than a billion adults worldwide, is an important risk factor for insulin resistance, hyperinsulinaemia, glucose intolerance, dyslipidaemia, hypertension, atherosclerosis and cardiovascular diseases. The comorbidity of these abnormalities and obesity is called metabolic syndrome 1. Abdominal obesity, high triglyceride levels, decreased low-density lipoprotein (LDL)-cholesterol levels, increased blood pressure and increased fasting blood glucose levels are the main components of the metabolic syndrome.…”

“…Almost one-third of the adult population in the world and in Turkey suffers from the metabolic syndrome 3. Although the pathogenesis of metabolic syndrome has not been thoroughly clarified, recently adipokines were considered to play a key role in the pathogenesis of metabolic syndrome 1. Of these adipokines, nesfatin-1, retinol-binding protein 4, omentin-1, vaspin and progranulin secreted from the adipose tissue through a large secretion network are directly involved in metabolic syndrome-related pathologies 4…”

“…The comorbidity of these abnormalities and obesity is called metabolic syndrome. 1 Abdominal obesity, high triglyceride levels, decreased low-density lipoprotein (LDL)-cholesterol levels, increased blood pressure and increased fasting blood glucose levels are the main components of the metabolic syndrome. As the metabolic syndrome includes these components, it also possesses a risk for type 2 diabetes and cardiovascular diseases.…”