2005
DOI: 10.1038/sj.bmt.1705004
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GI complications in pediatric patients post-BMT

Abstract: Summary:This retrospective study comprehensively examined hepatic and gastrointestinal complications post-bone marrow transplant (BMT) in a heterogeneous group of 132 pediatric patients that underwent 142 transplants. Hyperbilirubinemia occurred in 28% of this population with clinically evident jaundice in 16%. Acute graft-versus-host disease (GVHD) occurred in 46% of the population, with liver involvement in 39% and intestinal involvement in 60% of those with acute GVHD. Veno-occlusive disease (VOD) occurred … Show more

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Cited by 75 publications
(75 citation statements)
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“…37,38 Marrow transplant recipients may be predisposed to developing pancreatitis because of biliary sludge, use of irradiation or cytotoxic drugs in the conditioning regimen, prolonged medication with corticosteroids and CSA, and viral infections. 39,40 Our data do not show a relation of pancreatitis to these factors, although in three patients adenovirus was detected in stool and/or gastric secretion only during the course of aGVHD. As these patients were on combined immunosuppressive treatment, it is unclear whether reactivation of adenovirus in gastrointestinal tract was a consequence of immunosuppression or whether it caused pancreatitis.…”
Section: Discussionmentioning
confidence: 62%
“…37,38 Marrow transplant recipients may be predisposed to developing pancreatitis because of biliary sludge, use of irradiation or cytotoxic drugs in the conditioning regimen, prolonged medication with corticosteroids and CSA, and viral infections. 39,40 Our data do not show a relation of pancreatitis to these factors, although in three patients adenovirus was detected in stool and/or gastric secretion only during the course of aGVHD. As these patients were on combined immunosuppressive treatment, it is unclear whether reactivation of adenovirus in gastrointestinal tract was a consequence of immunosuppression or whether it caused pancreatitis.…”
Section: Discussionmentioning
confidence: 62%
“…The impact of GVHD specifically on oral intake has not been well studied but is known to cause significant nutrition-related problems in children and adults. 10,21 In a cohort of 18 children with multiorgan GVHD, a mean decrease in BMI of 20.9% was noted from HSCT date to the lowest BMI recorded. 22 We were unable to document a relationship between donor type and oral dietary intake.…”
Section: Discussionmentioning
confidence: 99%
“…Barker et al 9 examined gut complications following SCT in a heterogeneous group of 132 pediatric patients that underwent 142 transplants. Acute GVHD was most commonly diagnosed in conjunction with skin manifestations.…”
Section: Discussionmentioning
confidence: 99%