Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection

Michitaka, Kojiro; Horiike, Norio; Yan, Chen‐Hua; Dương, Trần Như; Konishi, Ichiro; Mashiba, Toshie; Terada, Yoshio; Hiasa, Yoichi; Tanaka, Yasuhito; Mizokami, Masashi; Onji, Morikazu

doi:10.2169/internalmedicine.43.696

Cited by 23 publications

(10 citation statements)

References 21 publications

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“…The HBV causing this syndrome was speculated to be an imported strain, as the majority of HBV subtypes in Japan are adr and adw , corresponding to HBV/C and HBV/B, respectively 15–17 . We have found that HBV isolates with subtype ayw obtained from a patient with Gianotti–Crosti syndrome in this area represented HBV/D on complete genome sequencing 18 . We thus speculated that the spread of HBV/D is closely related to the endemic Gianotti–Crosti syndrome in the 1970s.…”

Section: Introductionmentioning

confidence: 90%

“…[15][16][17] We have found that HBV isolates with subtype ayw obtained from a patient with Gianotti-Crosti syndrome in this area represented HBV/D on complete genome sequencing. 18 We thus speculated that the spread of HBV/D is closely related to the endemic Gianotti-Crosti syndrome in the 1970s. However, there is a paucity of available information regarding the geographic spread of HBV/D in this area.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan

Matsuura

Michitaka

Yamauchi³

et al. 2007

Hepatology Research

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan

Matsuura

Michitaka

Yamauchi³

et al. 2007

Hepatology Research

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“…Recently, we reported that the infectious agent that caused the outbreak in this area was suspected to be HBV genotype D [23,29] . It is convincing that genotype C was the common genotype involved in the co-infected cases in the present study, because C is the most prevalent genotype in this area.…”

Section: Discussionmentioning

confidence: 99%

Co-Infection with Hepatitis B Virus Genotype D and Other Genotypes in Western Japan

Michitaka

Horiike²,

Yan³

et al. 2005

Intervirology

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Objective: Genotypes B and C are the prevalent hepatitis B virus (HBV) genotypes in eastern Asia. Although very rare in this region of the world, genotype D was found to be prevalent in a small area of western Japan. In this study, we confirm the frequency and clinical significance of co-infection with different genotypes among patients from that area infected with genotype D. Methods: Twenty-three patients from the same area of western Japan infected with HBV genotype D, determined using a genotyping enzyme immunoassay, were studied. Cloning was done using DNA extracted from serum samples, and polymerase chain reaction assays with the restriction fragment length polymorphism for HBV genotyping were performed with 10 clones from each patient. Results: Four (17.4%) of the 23 patients were found to be co-infected with HBV genotype C, and the HB surface antigen subtype was ayw in both mono- and co-infected patients. No clinical differences were found between mono-infected and co-infected patients carrying genotype D. Conclusion: A significant number of patients from the study area found to be infected with HBV genotype D were co-infected with genotype C. Additional study with a larger number of patients is needed to elucidate the possible clinical significance.

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“…This is a syndrome of skin eruption described as papular acrodermatitis. It is mostly limited to children and not limited to HBV, but reported with acute HBV infection [43]. …”

Section: Treatment To Ameliorate Course Of Acute Hepatitis Bmentioning

confidence: 99%

Therapy of Acute and Fulminant Hepatitis B

Tillmann

Patel

2014

Intervirology

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Although new hepatitis B virus (HBV) infections are decreasing due to improving vaccination coverage, patients without vaccination coverage can still suffer from manifestation of acute hepatitis B with jaundice and (although rarely) liver failure. No treatment is indicated for mild acute hepatitis B; however, antiviral therapy should be initiated for patients showing signs of significant liver impairment as exemplified by deterioration of prothrombin time to an equivalent of 1.5 or 50% of the ‘Quick test'. For fulminant hepatitis, there is no complete agreement on whether antiviral treatment would alter the course, but it should still be started, as it would reduce the risk of reinfection in case there is a need for liver transplantation. Patients in danger of progression towards acute liver failure should be referred to transplant centers as early as possible.

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Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection

Cited by 23 publications

References 21 publications

Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan

Characteristics of geographic distributions and route of infection for hepatitis B virus genotype D in Ehime area in western Japan

Co-Infection with Hepatitis B Virus Genotype D and Other Genotypes in Western Japan

Therapy of Acute and Fulminant Hepatitis B

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