Gianotti-Crosti Syndrome following immunization in an 18 months old child

Abstract

Gianotti–Crosti syndrome (GCS) is an uncommon dermatological condition characterized by distinct, self-limiting, symmetrical, erythematous, papulovesicular eruptions distributed mainly on the extremities, buttocks and face in young children. Although GCS is commonly attributed to viral infections, vaccinations too can rarely precipitate this condition. We report a rare case of GCS following diptheria, pertussis, and tetanus (DPT) and oral polio immunisation in an 18-month-old child along with a review of similar vaccine-induced GCS cases reported in the literature.

Pattern of Papulosquamous Disorders in Children: A Clinico-Epidemiological Study

“…Males outnumbered females with a ratio of 1.57:1.0. Gianotti-Crosti syndrome commonly affects children between two to six years of age [30]. In the present study too, the majority of the cases belonged to the age group of 2-5 years (29.4%).…”

“…Babu and Arivazhahan [30] No cases of parapsoriasis and pityriasis rubra pilaris were reported in the present study. The low number of patients may be accountable for this.…”

“…Gianotti-Crosti syndrome is characterized by the presence of symmetric erythematous papular and papulovesicular eruptions over the face, extremities, and buttocks, and is commonly seen in the pediatric age group [1]. It has been classically associated with viral etiology, such as hepatitis B virus, as well as rarely with Epstein-Barr virus and cytomegalovirus [29][30]. Apart from viral infections, Gianotti-Crosti syndrome is also associated with vaccinations [30].…”

“…It has been classically associated with viral etiology, such as hepatitis B virus, as well as rarely with Epstein-Barr virus and cytomegalovirus [29][30]. Apart from viral infections, Gianotti-Crosti syndrome is also associated with vaccinations [30]. It formed 18.9% of the total pediatric cases with papulosquamous disorders.…”

A case-control study on the association of pulse oral poliomyelitis vaccination and Gianotti-Crosti syndrome

“…It was also reported that an 18‐month‐old child developed classical GCS rash 3 days after diphtheria, pertussis, tetanus, and oral polio vaccinations . However, the role of oral polio per se in this patient would be unknown, as four vaccines were administered concomitantly.…”