Gianotti-Crosti Syndrome Presenting as Lichenoid Dermatitis

Abstract

Papular acrodermatitis of childhood (Gianotti-Crosti syndrome) is an uncommon, self-limited disease characterized by an erythematous papular eruption symmetrically distributed on the face and limbs and mild lymphadenopathy, thought to be of viral origin. The histopathologic findings are nonspecific and include focal parakeratosis, mild spongiosis, superficial perivascular infiltrate, papillary dermal edema, and extravasated red blood cells. Interface changes with some basal vacuolization may be present, but are not a conspicuous feature. We present a 2 1/2-year-old boy with multiple papules and plaques on the face and extremities and cervical lymphadenopathy. Histopathologic analysis showed compact orthokeratosis, focal parakeratosis, hypergranulosis, psoriasiform epidermal hyperplasia, and a dense lichenoid lymphohistiocytic infiltrate with extensive exocytosis of mononuclear cells. Immunoperoxidase staining with CD 1 a revealed clusters of Langerhans cells in the epidermis and in the papillary dermis. In view of the clinical findings, a diagnosis of Gianotti-Crosti syndrome was made. Although there are a few reports describing a lichenoid pattern of infiltration in Gianotti-Crosti syndrome, this histologic pattern is not widely known. This case is presented to illustrate the fact that Gianotti-Crosti syndrome can present as lichenoid dermatitis, and, especially in children, should be added to the differential diagnoses of lichenoid infiltrates.

Cutaneous Infections Caused by Herpesviridae: A Review

“…Basal layer vacuolar change, red blood cell extravasation, and papillary dermal edema may be present as well (Figure 4, A and B). 13 Oral hairy leukoplakia is most often seen in human immunodeficiency virus-infected patients and in patients with other immunosuppressive conditions. ''Hairy'' irregular projections, composed of keratin and sometimes surrounded by parakeratosis, protrude from white plaques found on the lateral aspects of the tongue.…”

Síndrome de Gianotti-Crosti: aspectos clínicos, laboratoriais e perfis sorológicos observados em 10 casos procedentes de Belém-PA (Brasil)

“…Pesquisa de Gianotti (Table 1). [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In the literature consulted, there were only two references 5,7 to HHV6 as a cause of the disease.…”

“…Posteriormente foram observadas erupções cutâneas idênti-cas à da SGC, mas sem evidência de infecção aguda pelo vírus da hepatite B. Durante a investigação etiológica dos casos aqui apresentados, verificou-se que eram decorrentes de diferentes agentes infecciosos, principalmente virais (Tabela 1). [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Na literatura consultada, há apenas duas referências 5,7 ao HHV6 como causador da doença. O curso da SGC é benigno e autolimitado, desaparecendo as manifestações em prazo que varia de duas a oito semanas, sem recorrências.…”

“…O curso da SGC é benigno e autolimitado, desaparecendo as manifestações em prazo que varia de duas a oito semanas, sem recorrências. 3,4,6,7,10,[14][15][16] As lesões cutâneas são em geral assintomáticas, excepcionalmente pruriginosas. 4,7,8,10,13,14,16 Por vezes há pródromos sugestivos de infecção respiratória alta.…”

“…Uma linfocitose, eventualmente com presença de linfócitos atípicos no sangue periférico, pode ainda ser observada. 3,[7][8][9][10][13][14][15] …”