Giant adrenal myelolipoma: Case report and review of the literature

Yıldız, Levent; Akpolat, İlkser; Erzurumlu, Kenan; Aydın, Oğuz; Kandemır, Bedrı

doi:10.1046/j.1440-1827.2000.01071.x

Cited by 40 publications

(31 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These benign tumors may be associated with endocrine disorders such as hermaphroditism, Cushing's disease, Addison's disease, and obesity of unknown cause. Although giant myelolipomas have been reported in the literature, these tumors rarely measure >5 cm [26].…”

Section: Tumorsmentioning

confidence: 99%

Sudden Death due to Diseases of the Adrenal Glands and Paraganglia

Visonà¹,

Tajana²,

Osculati³

2017

Clinical Management of Adrenal Tumors

View full text Add to dashboard Cite

Coroners and pathologists commonly evaluate unexpected deaths due to diseases of the adrenal glands and paraganglia, which are, unfortunately, not rare in their totality. Although cardiac causes are the main cause of sudden death, endocrine conditions can produce sudden, unexpected deaths that need further investigation, especially in younger patients. This chapter focuses on the issue of sudden death due to diseases involving adrenal glands and paraganglia. The main causes of sudden death due to adrenal gland pathology will be examined, paying particular attention to the pathophysiology of sudden death, macroscopic and microscopic characteristics and their correlation with clinical features. These issues are of great interest, especially considering the clinical impact of sudden death and its rarity among patients with adrenal gland diseases. The forensic pathologist's examination is extremely important in determining the cause of death and findings not clinically observable and can contribute to the improvement of the clinical and surgical approach in treating such patients.

show abstract

Section: Tumorsmentioning

confidence: 99%

Sudden Death due to Diseases of the Adrenal Glands and Paraganglia

Visonà¹,

Tajana²,

Osculati³

2017

Clinical Management of Adrenal Tumors

View full text Add to dashboard Cite

show abstract

“…Myelolipomas are usually diagnosed by radiology utilizing ultrasound (US), computerized tomography (CT) and MRI. Unilateral adrenal fatty mass on CT is a valuable diagnostic clue in differential diagnosis [9,10]. Metastatic lesions to the adrenal gland are contrast enhancing and invasive in nature having densities greater than myelolipomas.…”

Section: Two Casesmentioning

confidence: 99%

“…Metastatic lesions to the adrenal gland are contrast enhancing and invasive in nature having densities greater than myelolipomas. In contrast to adenomas that have lesser adipose tissue image with intracellular fat density between 10-30 HU and adrenal cysts are easily diagnosed due to non-fatty features with densities close to water [3,6,7,9]. MRI with T1 and T2 weighted images show adipose tissue having high signal intensities and less contrast enhancement.…”

Section: Two Casesmentioning

confidence: 99%

Laparoscopic surgery for adrenal myelolipoma: Report of two cases

Ateş¹,

Karaca²,

Dirican³

et al. 2012

Med-Science

View full text Add to dashboard Cite

show abstract

“…Other symptoms (including amenorrhea, tachypnea, fever, and chest pain) were reported in 4.8% and 17.7% were found to be asymptomatic. Patients with giant myelolipomas [53][54][55][56][57][58][59][60][61][62][63][64][65][66] can present with intraabdominal hemorrhage secondary to tumor necrosis produced by trauma or severe physical stress, surgery, septicemia, hypertension, or anticoagulant therapy. lesions or clinical entities: hypertension 27.8%, obesity 19.9%, nonfunctioning adrenal adenoma 9.3%, Cushing syndrome 7.9%, diabetes mellitus 6.6%, congenital adrenal hyperplasia (CAH) resulting from CYP21 deficiency 6.6%, cardiovascular disease 5.3%, nephrolithiasis 4%, primary aldosteronism 2.6%, Cushing disease 1.98%, pheochromocytoma 1.98%, hypogonadism 1.3%, CAH resulting from 11␤ hydroxylase deficiency 0.66%, CAH resulting from 17␤ hydroxylase deficiency 0.66%, polycystic ovaries disease in 0.66%, and Carney complex 0.66%.…”

Section: Clinical Featuresmentioning

confidence: 99%

Two Siblings With Untreated CYP21 Deficiency and Giant Myelolipomas

Rodríguez-Vallejo

Gómez-Pérez²

2006

The Endocrinologist

View full text Add to dashboard Cite

The authors present the case histories of 2 siblings with the virilizing form of congenital adrenal hyperplasia (CYP21 deficiency). The diagnosis was established during the neonatal period; however, glucocorticoid therapy was inconsistent. At the age of 30, the first case presented with pain in the right upper quadrant. An ultrasound scan disclosed a large mass occupying the greater part of the abdominal cavity. On computed tomography, this mass showed characteristics compatible with myelolipoma. The diagnosis was confirmed by pathologic examination. Interestingly, the sister of this patient, who was asymptomatic, was found to have similar tumors on both adrenal glands by ultrasound examination. The pathologic examination of these tumors confirmed the diagnosis of myelolipoma. The precise mechanism of myelolipoma development is not known. Prolonged ACTH stimulation could be a contributing factor. Both patients are now being treated with glucocorticoids. A review of the literature is presented. Learning Objectives• Appraise competing explanations of how myelolipomas may develop in patients with CYP21 deficiency, the virilizing form of congenital adrenal hyperplasia. • Relate the clinical and imaging features of myelolipoma as noted in a literature review of more than 200 patients, as well as possible complications and associated disorders. • List treatment options for myelolipoma and suggest ways of choosing between them. CASE REPORTS Case 1T his case report presents a 31-year-old Mexican woman with virilizing CYP21 hydroxylase deficiency. Shortly after birth, she had corrective surgery for ambiguous genitalia. She was treated with prednisone between 2 and 14 years of age. One year before admission, she developed a dull pain in the left upper quadrant associated with dyspepsia. On examination, she had a body mass index (BMI) of 36 kg/m 2 and a blood pressure of 120/70 mm Hg. Acanthosis nigricans and skin tags on the neck and axillae were prominent. A tender abdominal mass was identified in the left upper quadrant. A computed tomography (CT) scan (Fig. 1A) confirmed the presence of a large mass apparently attached to the left adrenal gland.

show abstract

Giant adrenal myelolipoma: Case report and review of the literature

Cited by 40 publications

References 8 publications

Sudden Death due to Diseases of the Adrenal Glands and Paraganglia

Sudden Death due to Diseases of the Adrenal Glands and Paraganglia

Laparoscopic surgery for adrenal myelolipoma: Report of two cases

Two Siblings With Untreated CYP21 Deficiency and Giant Myelolipomas

Contact Info

Product

Resources

About