Giant aneurysm of the vertebral artery in neurofibromatosis type 1: report of a case and review of the literature

Hoffmann, Karl‐Titus; Hosten, Norbert; Liebig, Thomas; Schwarz, Karin; Félix, R.

doi:10.1007/s002340050576

Cited by 31 publications

(17 citation statements)

References 16 publications

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“…The usual pathogenesis of aneurysms in this location is considered to be either penetrating or blunt trauma with resultant pseudoaneurysm formation. Although rarely described in the literature, aneurysms of the vertebral artery do occur as a manifestation of vascular disease with neurofibromatosis [3,6,8,11,12]. In the case presented here we are convinced that the two aneurysms found in our patient are true aneurysms of which the vertebral artery aneurysm had probably an intramural bleeding due to dissection leading to the radiculopathy.…”

Section: Discussionsupporting

confidence: 57%

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An Aneurysm of the Cervical Vertebral Artery Causing Radiculopathy?An Unusual Case

Börm

Antoniadis

Müller³

et al. 2003

Klinische Neuroradiologie

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Case Report: We report on a 37-year-old woman with a 10-week history of neck pain and brachialgia along the right C6 dermatome. Neurological findings included weakness of the right biceps muscle and hypesthesia of the right thumb. The patient was diagnosed as having von Recklinghausen's disease (neurofibromatosis 1) 10 years ago, and a CT scan demonstrated an extraspinal paravertebral mass with osseous arrosion of the right vertebral foramen at C6. The primary diagnosis was neurofibroma, but further diagnostic workup including MRI, MR angiography and digital subtraction angiography revealed an extracranial vertebral artery aneurysm compressing the right C6 root. An attempt to occlude the aneurysm by coil embolization failed in another institution. Further interventions were rejected by the patient who experienced spontaneous resolution of her complaints and complete neurological recovery within a few weeks. ZusammenfassungFallbeschreibung: Wir berichten über eine 37-jährige Patientin mit therapieresistenter Zervikobrachialgie entsprechend dem Dermatom C6 rechts über 10 Wochen. Die neurologische Untersuchung ergab eine Schwäche des Musculus biceps rechts sowie eine Daumenhypästhesie rechts. Bei der Patientin wurde 10 Jahre zuvor ein Morbus Recklinghausen (Neurofibromatose Typ 1) diagnostiziert, und eine CT-Untersuchung zeigte eine extraspinale, paravertebrale Raumforderung mit Knochenarrosion im Bereich des Neuroforamens C6 rechts. Die primäre Verdachtsdiagnose war ein Neurofibrom, aber die erweiterte Diagnostik mit MRT, MR-Angiographie und digitaler Subtraktionsangiographie ergab ein extrakranielles Aneurysma der Arteria vertebralis mit Kompression der C6-Wurzel rechts. Ein Embolisationsversuch mit Coils, durchgeführt an einer anderen Klinik, war erfolglos. Weitere therapeutische Maßnahmen wurden von der Patientin abgelehnt. Im weiteren Verlauf klangen die geklagten Beschwerden vollständig ab, und die neurologischen Defizite bildeten sich in wenigen Wochen komplett zurück.

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Section: Discussionsupporting

confidence: 57%

“…Furthermore, association of vascular anomalies and neurofibromatosis is reported with increasing frequency [3,4,6,8,11,12 ].…”

Section: Introductionmentioning

confidence: 99%

An Aneurysm of the Cervical Vertebral Artery Causing Radiculopathy?An Unusual Case

Börm

Antoniadis

Müller³

et al. 2003

Klinische Neuroradiologie

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“…5), stenosis or occlusion of major vessels, AV-fistulae, arteriovenous malformations [50,51]; a significantly higher detection rate of IAs in NF-1 than in a population is reported [52].…”

Section: Association With Heritable Conditionsmentioning

confidence: 95%

Epidemiology and genetics of intracranial aneurysms

Caranci

Briganti

Cirillo

et al. 2013

European Journal of Radiology

150

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“…14,20) However, extracranial VA aneurysm is rarely associated with neurofibromatosis. 1,2,5,6,[8][9][10]12,13,[15][16][17][18][19][20] We report a case of ruptured extracranial VA aneurysm in a patient with NF1 treated successfully by endovascular embolization.…”

Section: Introductionmentioning

confidence: 99%

Ruptured Extracranial Vertebral Artery Aneurysm Associated With Neurofibromatosis Type 1

Hiramatsu

Matsui

Yamashita

et al. 2012

Neurol. Med. Chir.(Tokyo)

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A 31-year-old man presented with a ruptured right extracranial vertebral artery aneurysm associated with neurofibromatosis type 1, manifesting as acute onset of right neck and shoulder pain, and right supraclavicular mass. Three-dimensional computed tomography angiography showed a large aneurysm involving the right extracranial vertebral artery associated with a pseudoaneurysm. The aneurysm was successfully treated by transarterial endovascular trapping with detachable coils. Extracranial vertebral artery aneurysm is rare, but the mortality of ruptured cases is extremely high, so early diagnosis and early treatment are important. The present case shows that endovascular treatment was very effective.

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Giant aneurysm of the vertebral artery in neurofibromatosis type 1: report of a case and review of the literature

Cited by 31 publications

References 16 publications

An Aneurysm of the Cervical Vertebral Artery Causing Radiculopathy?An Unusual Case

An Aneurysm of the Cervical Vertebral Artery Causing Radiculopathy?An Unusual Case

Epidemiology and genetics of intracranial aneurysms

Ruptured Extracranial Vertebral Artery Aneurysm Associated With Neurofibromatosis Type 1

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