Giant angiofibromas in tuberous sclerosis complex: A possible role for localized lymphedema in their pathogenesis

Giant cell angiofibroma of gingiva in tuberous sclerosis complex: a case report and literature review

“…However, unlike other case reports with usual fibromas, histological evaluation of the excised gingival tissue, in this case, revealed multiple Touton-type giant cells, numerous dilated capillaries, and abundant pleomorphic, stellate-shaped fibroblasts consistent with giant cell angiofibroma. Kacerovska, D., et al [17] found Touton giant cells in cutaneous specimens of a TSC patient and established a diagnosis of GCA based on histological examination. In their report, the authors used 42 lesional specimens from large disfiguring facial angiofibromas in a patient with TSC.…”

Tuberous sclerosis complex: Diagnostic role of magnetic resonance imaging

“…The exquisite exposition of microscopic pathology[ 1 11 ] was fascinating and is required to be taken cognizance of as an essential adjunct for confirming the clinical diagnosis. Virtually, it should form a part component of already enlisted major and/or minor features of TSC.…”

“…Tuberous sclerosis is a genetic disorder, where cellular differentiation and proliferation result in hamartoma formation in the skin, brain, eye, kidney, and heart. [ 1 2 ] The credit of its initial description, in the year 1862, goes to Von Recklinghausen,[ 3 ] while Désiré-Magloire Bourneville[ 4 ] coined the term sclerose tubereuse ; the current name is its derivative. The clinical triad of epilepsy, low intelligence, and adenoma sebaceum, the epiloia , was invented by Sherlock.…”

“…The clinical triad of epilepsy, low intelligence, and adenoma sebaceum, the epiloia , was invented by Sherlock. [ 5 ] The term tuberous sclerosis complex (TSC)[ 1 ] is now widely acclaimed, emphasizing the variegated nature of its attribute.…”