Giant Blue Nevus: A New Association to Nevus of Ota

Medel, Ramón; Vasquez, LuzMaria; Fernandez, J. Fraga; Huguet, Pere; Romero, J. Pamias

doi:10.3109/01676830.2015.1049372

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…In 1973, Speakman and Phillips [13] reported two cases of cellular and malignant blue nevus presenting in the orbit in patients with oculodermal melanosis. Similarly, in 2015, Medel et al [14] reported a third case of giant orbital cellular blue nevus and oculodermal melanocytosis in a 20-year-old male that was managed with excisional biopsy. Buntinx-Krieg et al [15] went on to report a 45-year-old female with oculodermal melanocytosis and orbital cellular blue nevus that subsequently underwent transformation to malignant melanoma.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Intra-Scleral Blue Nevus Arising within Oculodermal Melanocytosis: Melanoma or Not?

2020

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• Blue nevi arising in the sclera are uncommon, with only three prior cases documented in the literature, none of which arose within an area of ocular melanocytosis. • Oculodermal melanocytosis, a subtype of congenital dermal dendritic melanocytic proliferation, is well known to carry a risk (1/400) of uveal melanoma. Novel Insights • To our knowledge, this case is the first report of a scleral blue nevus arising within an area of oculodermal melanocytosis, suggesting a potential association between the two subtypes of congenital dermal dendritic melanocytic proliferations. • Although generally considered a benign condition, the cellular atypia and scleral expansion noted in our case may represent an intermediate stage in the potential progression from ocular melanocytosis towards melanoma.

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Section: Discussion/conclusionmentioning

confidence: 99%

Intra-Scleral Blue Nevus Arising within Oculodermal Melanocytosis: Melanoma or Not?

2020

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“…Em relato mostrado por Medel et al (2015) um homem, branco, jovem de 20 anos apresentou-se para consulta com queixa de proptose indolor do olho direito, observado algumas semanas antes. Ele havia sido diagnosticado com nevo de Ota no olho direito aos 5 anos de idade e confirmado com uma biópsia aos 10 anos em outra instituição.…”

Section: Discussionunclassified

“…Uma Punção Aspirativa por Agulha Fina (PAAF) foi realizada e relatou nevo azul atípico, mas era impossível descartar o melanoma maligno com a amostra. Dado o comportamento clínico da massa, o tempo de evolução e a dificuldade de estabelecer um diagnóstico histológico claro com a PAAF, a cirurgia não conservadora foi proposta (MEDEL et al, 2015).…”

Section: Discussionunclassified

Melanocitose Óculo-Dermal: Risco Inerente Ou Evitável?

Savian¹,

Fraga²,

Fraga³

2019

Semana Acadêmica

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RESUMOA melanocitose ocular é uma lesão pigmentar congênita, unilateral, consistindo em uma forma de nevo ou nevus. O nevus localiza-se na episclera profunda, esclera e trato uveal e pode manifestar-se clinicamente como heterocromia da íris, como uma descoloração irregular acinzentada ou azulada da esclerótica, e aumento da pigmentação do fundo ipsilateral. O problema levantado foi que os pacientes acometidos estão em maior risco de desenvolver doenças metastáticas no olho afetado. Se o nevo envolver a pele periocular e o olho, a condição é conhecida como melanocitose óculo-dermal (MOD) ou nevo de Ota. Essa pesquisa buscou analisar a relação entre MOD e doenças metastáticas e averiguar se é um risco inerente ou evitável. Para explicitar o tema e demais descrições e postulações, foi efetuada uma revisão de literatura de informações e definições relevantes. Concluiu-se que a relação entre MOD e o desenvolvimento de doenças metastáticas é uma informação importante e deve ser reconhecida. Dada a correlação entre MOD e o melanoma uveal de alto risco (por exemplo), os pacientes que manifestam MOD difusa ou setorial devem ser examinados minuciosamente duas vezes por ano.Palavras-chave: Neoplasias Oculares. Nevo. Nevo pigmentado. Nevo de Ota. Manifestações Oculares. ABTRACTOcular melanocytosis is a congenital, unilateral pigment lesion that is a form of nevus. Nevus is located in the deep episclera, sclera and uveal tract and may manifest clinically as iris heterochromia, irregular smoked-gray or blue discoloration of the sclera, and increased pigmentation of the ipsilateral fundus. These patients are at higher risk of developing metastatic disease in the affected eye. If the nevus involves the periocular skin and the eye, the condition is known as dermal oculus melanocytosis (MOD). Through this research we have tried to describe why ocular melanocytosis, causes, diagnosis and treatments. In order to explain the

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“…Contrastingly, cellular blue nevi, commonly found on the buttocks or scalp, are a typically benign variant of common blue nevi that are histologically characterized by dense cellularity and abundant melanin. The term “atypical cellular blue nevus” (ACBN) is used to describe borderline forms of cellular blue nevus with additional features (asymmetry, hypercellular foci, focal cytologic atypia, and occasional mitoses) that are suggestive of melanoma but not definitive [ 4 ]. There are few case reports describing the malignant potential of these histologically distinct lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Similar phenomena showing the malignant potential of nevus of Ota and cellular blue nevus have been reported. Medel, et al described a Caucasian man with a nevus of Ota and ocular melanosis at the inferior fornix of the right eye that appeared to extend into the orbital space [ 4 ]. This patient had worsening proptosis, and a post-excisional diagnosis of atypical giant cellular blue nevus on a nevus of Ota was made.…”

Section: Discussionmentioning

confidence: 99%

An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota

Buntinx-Krieg

Ouyang

Cartwright

2016

Cureus

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Melanomas arising from orbital melanocytic proliferations are exceedingly rare. Many questions remain regarding their development and malignant transformation. We report on a 45-year-old Caucasian woman with a nevus of Ota that presented with visual disturbances involving her right eye and was found to have a biopsy-proven cellular blue nevus in the orbital space. Five years later, she presented with proptosis and worsening symptoms. Biopsy at that time showed a cellular blue nevus with areas of melanoma. We conclude that patients with a nevus of Ota or an orbital cellular blue nevus, particularly Caucasians, should be monitored for ocular/orbital involvement and followed closely for signs of rapid growth. There may be a progressive evolution to melanoma from a blue nevus.

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Giant Blue Nevus: A New Association to Nevus of Ota

Cited by 11 publications

References 11 publications

Intra-Scleral Blue Nevus Arising within Oculodermal Melanocytosis: Melanoma or Not?

Intra-Scleral Blue Nevus Arising within Oculodermal Melanocytosis: Melanoma or Not?

Melanocitose Óculo-Dermal: Risco Inerente Ou Evitável?

An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota

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