Giant Cell Arteritis and Mortality

Crow, Robert W.; Katz, Bradley J.; Warner, Judith E. A.; Alder, Stephen C.; Zhang, Kang; Schulman, Susan; Digre, Kathleen B.

doi:10.1093/gerona/gln030

Cited by 51 publications

(28 citation statements)

References 30 publications

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“…However, the mortality was higher early in the disease course, especially in patients younger than 70 years at time of diagnosis. Most previous studies showed no increase in mortality compared with the general population,13 including studies of patients with biopsy-proven GCA from Gothenburg14 and Australia 17. Increased mortality was previously reported in studies from Denmark16 and northern Sweden,30 in the latter, mainly due to cardiovascular disease.…”

Section: Discussionmentioning

confidence: 83%

Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden

Mohammad

Nilsson

Jacobsson

et al. 2015

Annals of the Rheumatic Diseases

109

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Section: Discussionmentioning

confidence: 83%

Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden

Mohammad

Nilsson

Jacobsson

et al. 2015

Annals of the Rheumatic Diseases

109

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“…We demonstrated no difference in survival from the general population at any time, a finding that contrasts with several studies that demonstrated increased mortality at 5 years, but no effect at 10-11 years 4,8 . The strengths of our study are that it included only patients with a confirmed diagnosis of GCA through biopsy and a large sample size (only a Swedish study by Nordborg and Bengtsson in 1989 with 284 patients being larger 7 ).…”

Section: Discussionmentioning

confidence: 99%

Mortality in Patients with Biopsy-proven Giant Cell Arteritis: A South Australian Population-based Study

Ninan¹,

Nguyen²,

Cole³

et al. 2011

J Rheumatol

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“…3 Patients with GCA are usually considered to have survival rates equivalent to the age-matched population 31 ; however, evidence has been mixed. 32 In our cohort, we found a higher mortality in the GCA cohort; this may be because prior cardiovascular and cerebrovascular disease were more commonly seen in GCA patients.…”

Section: Discussionmentioning

confidence: 58%

The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK

Robson

Kiran

Maskell

et al. 2015

Annals of the Rheumatic Diseases

151

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ObjectivesTo evaluate the risk of aortic aneurysm in patients with giant cell arteritis (GCA) compared with age-, gender- and location-matched controls.MethodsA UK General Practice Research Database (GPRD) parallel cohort study of 6999 patients with GCA and 41 994 controls, matched on location, age and gender, was carried out. A competing risk model using aortic aneurysm as the primary outcome and non-aortic-aneurysm-related death as the competing risk was used to determine the relative risk (subhazard ratio) between non-GCA and GCA subjects, after adjustment for cardiovascular risk factors.ResultsComparing the GCA cohort with the non-GCA cohort, the adjusted subhazard ratio (95% CI) for aortic aneurysm was 1.92 (1.52 to 2.41). Significant predictors of aortic aneurysm were being an ex-smoker (2.64 (2.03 to 3.43)) or a current smoker (3.37 (2.61 to 4.37)), previously taking antihypertensive drugs (1.57 (1.23 to 2.01)) and a history of diabetes (0.32 (0.19 to 0.56)) or cardiovascular disease (1.98 (1.50 to 2.63)). In a multivariate model of the GCA cohort, male gender (2.10 (1.38 to 3.19)), ex-smoker (2.20 (1.22 to 3.98)), current smoker (3.79 (2.20 to 6.53)), previous antihypertensive drugs (1.62 (1.00 to 2.61)) and diabetes (0.19 (0.05 to 0.77)) were significant predictors of aortic aneurysm.ConclusionsPatients with GCA have a twofold increased risk of aortic aneurysm, and this should be considered within the range of other risk factors including male gender, age and smoking. A separate screening programme is not indicated. The protective effect of diabetes in the development of aortic aneurysms in patients with GCA is also demonstrated.

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Giant Cell Arteritis and Mortality

Abstract: Patients with GCA were more likely than age- and gender-matched controls to die within the first 5 years following diagnosis.

Cited by 51 publications

References 30 publications

Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden

Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden

Mortality in Patients with Biopsy-proven Giant Cell Arteritis: A South Australian Population-based Study

The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK

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