Giant-Cell Granuloma in the Temporal Bone: A Case Report and Review of the Literature

Giant Cell Reparative Granuloma in the Temporal Bone of the Skull Base: Report of Two Cases

“…In 1974, Hirschl and Katz were the first to report GCRG in the temporal bone, and since then only sporadic cases have been reported. 3,[10][11][12] The correct diagnosis of GCRG before surgery is difficult, although some investigators have indicated that characteristic MRI findings include a thick low T1-weighted and T2-weighted signal rim with variable central signal. [13][14][15] Indeed, several other lesions, and in particular giant cell bone tumor, also have similar imaging characteristics.…”

“…GCRG in the temporal bone is extremely rare and only a few sporadic cases have been reported. [1][2][3] Because of the characteristic that GCRG cells grow expansively and aggressively, GCRG often causes destruction of adjacent cortical bone and exhibits no significant changes in imaging, making it difficult to distinguish GCRG from other osteolytic bone lesions. Correct diagnosis is an interdisciplinary challenge, particularly when this lesion arises in an exceptional location.…”

Congenital Giant Cell Granuloma of the Temporal Bone

“…In the reported cases of temporal bone GCRG, a complete resection of the tumor is usually preferred owing to concern of a 50% rate recurrence after simple curettage. 10 Other therapies, including intralesional calcitonin, radiotherapy, and anti-inflammatory treatment, have been reported as alternatives to surgery. In our case, surgical resection was delayed while treatment with intravenous and intralesional steroids was attempted.…”

Giant cell reparative granuloma of the temporal bone successfully resected with preservation of hearing

“…1 Giant cell reparative granuloma involving the temporal bone is extremely rare, and there have been no previous reports of hearing preservation following resection of this tumour in the temporal bone. 2 We report a case of extensive giant cell reparative granuloma of the temporal bone which was successfully resected, with hearing preservation, using a transmastoid approach.…”