Giant cell granuloma of the jawbones – a proliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor

Abstract

The low mean MVV of VEGF- and bFGF-positive blood vessels implies low angiogenic activity, which does not support the designation of CGCG as a true proliferative vascular lesion. MC and GC immunoreactivity for the angiogenic factors is assumed to play an important role in the osteoclastogenesis process, thus contributing to additional growth of the CGCG lesions.

Clinico-Pathologic Conference AAOMP/IAOP 2008: Case 3

“…Retrospectively, we assessed angiogenesis within the lesional tissue by examining the frequency of newly formed blood vessels, using antibodies to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). As the tumor contained only a few small stained blood vessels, indicating a relatively minimal process of angiogenesis, the effectiveness of an anti-angiogenic agent in this case do not seem to be of a great value, unless it has additional mechanisms of action, for example on the lesional cells [6]. Unfortunately, after a 5-month period of treatment with INFa-2a, a new recurrence developed.…”

Neurofibromatosis type 1 associated with bilateral central giant cell granuloma of the mandible

“…It is unlikely that central giant cell granuloma is a true proliferative vascular lesion (Vered et al, 2006), but the immunoreactivity of the lesional mononuclear and giant cells for angiogenic factors probably has an important role in the osteoclastogenic process and thereby contributes to the growth of the lesion. Interferon alpha given alone for aggressive central giant cell granuloma is capable of terminating the rapid growth of the lesion and reducing its size (de Lange et al, 2006), but to date a total remission after treatment with interferon alpha has been reported in only one patient (Collins, 2000).…”

Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases

“…CGCG occurs predominantly in children or young adults, with approximately 75% of cases presenting before 30 years of age although presentation can occur at any age (Whitaker and Waldron, 1993). Females are affected more frequently than males, with a ratio of 2:1 (Waldron and Shafer, 1966;Bhaskar et al, 1971;Andersen et al, 1973;Eisenbud et al, 1988;Sidhu et al, 1995;de Lange et al, 2004).…”

“…Females are affected more frequently than males, with a ratio of 2:1 (Waldron and Shafer, 1966;Bhaskar et al, 1971;Andersen et al, 1973;Eisenbud et al, 1988;Sidhu et al, 1995;de Lange et al, 2004).…”

“…The histological appearance of CGCG is similar to that of brown tumours seen in hyperparathyroidism, and the latter diagnosis should be excluded by performing laboratory analysis. The true nature of CGCG remains speculative and considerable controversy exists in the literature (Chuong et al, 1986;Eisenbud et al, 1988;Whitaker and Waldron, 1993;de Lange and van den Akker, 2005).…”