Giant Cell Hepatitis in Copper Toxicosis

Vij, Mukul; Sankaranarayanan, Srinivas; Sankaranarayanan, Valavanur Subramanian; Manoharan, Rakesh; Sundaram, Sivanandam

doi:10.1016/j.jceh.2021.07.006

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Measurement of heavy metal and pesticide residues in toxic zongzi leaves (obtained from online stores) and non-toxic zongzi leaves (purchased from o ine supermarkets) demonstrated that the copper content in online-purchased zongzi leaves was nearly 80 times higher compared to that of zongzi leaves bought from physical supermarkets. Previous studies [20][21][22][23] have documented the detrimental effects of copper toxicity on the liver, including its ability to facilitate immune cell apoptosis and trigger in ammatory reactions. Additionally, elevated copper concentrations have been found to induce pathological damage in the liver and gills of various organisms, such as Mysis relicta, resulting in suppressed enzyme activity and subsequent accumulation of fat.…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of Indocalamu leaves based on acute toxicity, harmful heavy metals, and 9 organochlorine residue determination

Liu,

Li,

Wang

et al. 2024

Preprint

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To investigate the safety of zongzi leaves sold in the market, a study was conducted using zongzi leaves randomly collected from an online store and a large supermarket. Acute toxicity experiments were performed on mice, and their body weight was monitored for 14 days after administration. After the observation period, blood samples were collected for biochemical analysis, and organ pathology was examined. Then, the content of copper, lead, cadmium, mercury, arsenic, and the residues of nine organochlorine pesticides in zongzi leaves were measured according to the national standard GB/T5009-2003 and the residue determination method in the 2020 edition of the Chinese Pharmacopoeia. The results showed that the mice in the zongzi leaf (online store) group experienced mortality and severe liver and lung damage. The levels of lead, cadmium, mercury, arsenic, and the nine organochlorine pesticides met the relevant standards and regulations. However, the copper content in the zongzi leaf (supermarket) group was nearly 80 times higher than that in the online store group. Mice in the zongzi leaf (supermarket) group remained healthy without any abnormalities, and the levels of harmful heavy metals and organochlorine pesticides complied with the standards and regulations. The study suggests the need for regulatory policies and safety standards for the sale of zongzi leaves.

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Section: Discussionmentioning

confidence: 99%

Safety evaluation of Indocalamu leaves based on acute toxicity, harmful heavy metals, and 9 organochlorine residue determination

Liu,

Li,

Wang

et al. 2024

Preprint

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show abstract

“…Recently, a case report documented a 4-month-old infant with cholestasis diagnosed with copperrelated liver toxicity on liver biopsy. The use of a copper cup to prepare formula milk was likely an exogenous source of copper, and the child's condition improved after removing the exogenous copper source [11]. These studies suggest that excessive intake of copper from the environment may contribute to the development of liver cirrhosis.…”

Section: Introductionmentioning

confidence: 88%

Mendelian Randomization Study Suggests Circulating Copper Level as a Risk Factor for Liver Cirrhosis

Tang

Miao

et al. 2023

Preprint

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Cirrhosis is a serious liver disease with an unclear etiology and pathogenesis. Previous studies suggest a correlation between circulating copper and cirrhosis. However, whether circulating copper is a risk factor for cirrhosis is currently controversial because the liver is a major organ of copper metabolism and cirrhosis affects copper circulation. To address this, we used a mendelian randomization to explore the effect of circulating copper concentration on the risk of cirrhosis. We selected instrumental variables (IVs) of circulating copper from genome-wide association studies and analyzed two datasets from FinnGen, one for cirrhosis in general and the other for cirrhosis caused by non-alcoholic fatty liver disease (NAFLD). The inverse-variance weighted method was primarily used for mendelian randomization analysis. We created two SNP IVs that were associated with circulating copper, and their genetic associations with cirrhosis were extracted from the two datasets. The cirrhosis-related dataset included 811 cirrhosis patients and 273,592 controls, while the dataset for cirrhosis caused by NAFLD included 437 cirrhosis patients and 216,861 controls. Mendelian randomization analysis predicted a significant association between higher levels of circulating copper and increased risk of cirrhosis of liver (OR = 1.82, 95% CI: 1.30 to 2.54, P < 0.001). Additionally, higher levels of circulating copper were also associated with increased risk of cirrhosis of liver caused by NAFLD (OR = 1.68, 95% CI: 1.08 to 2.60, P = 0.021). The study suggests that higher levels of circulating copper may be a pathogenic risk factor for cirrhosis, providing important insights for the prevention and treatment of cirrhosis.

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Safety evaluation of Indocalamus Iatifolius McClure leaves based on acute toxicity, harmful metals, and 9 organochlorine residue determination

Liu,

Li,

Wang

et al. 2024

Sci Rep

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To investigate the safety of Indocalamu Iatifolius McClur leaves sold in the market, a study was conducted using Indocalamu Iatifolius McClur leaves randomly collected from an online store and a large supermarket. Acute toxicity experiments were performed on mice, and their body weight was monitored for 14 days after administration. After the observation period, blood samples were collected for biochemical analysis, and organ pathology was examined. Then, the content of copper (Cu), lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), and the residues of nine organochlorine pesticides in Indocalamu Iatifolius McClur leaves were measured according to the National Food Safety Standard (GB/T5009-2003) and the pesticide residue determination methods in the 2020 edition of the Chinese Pharmacopoeia. The results showed that the mice in the Indocalamu Iatifolius McClur leaves (online store) group experienced mortality and severe liver and lung damage. The levels of lead, cadmium, mercury, arsenic, and the nine organochlorine pesticides met the relevant standards and regulations. However, the copper content in the Indocalamu Iatifolius McClur leaves (online store) group was nearly 80 times higher than that in the supermarket group. Mice in the Indocalamu Iatifolius McClur leaves (supermarket) group remained healthy without any abnormalities, and the levels of harmful metals and organochlorine pesticides complied with the standards and regulations. The study suggests the need for regulatory policies and safety standards for the sale of Indocalamu Iatifolius McClur leaves.

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Giant Cell Hepatitis in Copper Toxicosis

Cited by 3 publications

References 5 publications

Safety evaluation of Indocalamu leaves based on acute toxicity, harmful heavy metals, and 9 organochlorine residue determination

Safety evaluation of Indocalamu leaves based on acute toxicity, harmful heavy metals, and 9 organochlorine residue determination

Mendelian Randomization Study Suggests Circulating Copper Level as a Risk Factor for Liver Cirrhosis

Safety evaluation of Indocalamus Iatifolius McClure leaves based on acute toxicity, harmful metals, and 9 organochlorine residue determination

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