Giant Cell Lesion or Langerhans' Cell Histiocytosis of the Mandible? A Case Report

Valentini, Virginia; Terenzi, Valentina; Cassoni, Andrea; Bosco, Sandro; Brauner, Edoardo; Shahinas, Jorida; Pompa, Giorgio

doi:10.1177/1721727x1201000122

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Exercise has been shown to enhance in vitro macrophage antitumor cytotoxicity (60)(61)(62)(63)(64) and, in accordance with the immune surveillance theory, it is to be expected that moderate exercise protects against malignancy whereas exhaustive exercise is linked to increased cancer risk. Relatively low intake of fruit and vegetables is a risk factor for many of the most important chronic diseases (65)(66)(67)(68)(69)(70), whereas greater consumption of natural products -including, spices, nuts, whole-grain cereals, legumes, fruits and vegetables is associated with a lower risk of many diseases (71)(72)(73)(74)(75)(76). Chronic inflammation is one of the foremost risk factors for different types of cancer.…”

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confidence: 99%

Nutrition and Cancer Prevention

Tetè

Nicoletti

Saggini

et al. 2012

Int J Immunopathol Pharmacol

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Cancer cells invade surrounding tissues and metastasize to distant sites. Diet high in fat is a strong link to, and perhaps causes, a high incidence of tumours. Trans-fatty acid might impair the function and it could be involved in the development of cancer. Cholesterol is also strongly suspected to be involved in the development of tumours, therefore it is important for everyone to eat well, especially for people with cancer to prevent the body tissues from breaking down and helping to rebuild the normal tissue that may have been affected by the treatments. Factors secreted by adipocytes and macrophages such as TNF-alpha and other inflammatory proteins are involved in inflammation in cancer. In addition, MCSF which up-regulates adipocyte tissue is also important for the stimulation of fat cell proliferation and is expressed by human adipocytes. Many cytokines, such as IL-1, IL-6, IL-8, IL-32, IL-33 and MCP-1, are biomarkers for cancer and chronic diseases along with transcription factors NFκB and AP-1; these last two factors are important bioactive substances on the molecular mechanism of the control of genes which in turn affect cellular metabolism. In this paper we revisit the interrelationship between cancer and metabolism.

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confidence: 99%

Nutrition and Cancer Prevention

Tetè

Nicoletti

Saggini

et al. 2012

Int J Immunopathol Pharmacol

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“…The prosthodontic treatment outcome is one of the most important parameters by which a patient measures the restoration of aesthetic, functional, and psychological deficits caused by trauma [ 10 , 31 , 37 , 38 , 39 ]. In our opinion, the best treatment is an implant-retained prosthesis: the literature agrees that a fixed prosthesis gives patients greater satisfaction than a mobile one.…”

Section: Discussionmentioning

confidence: 99%

Dental Management of Maxillofacial Ballistic Trauma

Brauner

Laudoni

Amelina

et al. 2022

JPM

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Maxillofacial ballistic trauma represents a devastating functional and aesthetic trauma. The extensive damage to soft and hard tissue is unpredictable, and because of the diversity and the complexity of these traumas, a systematic algorithm is essential. This study attempts to define the best management of maxillofacial ballistic injuries and to describe a standardized, surgical and prosthetic rehabilitation protocol from the first emergency stage up until the complete aesthetic and functional rehabilitation. In low-velocity ballistic injuries (bullet speed <600 m/s), the wound is usually less severe and not-fatal, and the management should be based on early and definitive surgery associated with reconstruction, followed by oral rehabilitation. High-velocity ballistic injuries (bullet speed >600 m/s) are associated with an extensive hard and soft tissue disruption, and the management should be based on a three-stage reconstructive algorithm: debridement and fixation, reconstruction, and final revision. Rehabilitating a patient with ballistic trauma is a multi-step challenging treatment procedure that requires a long time and a multidisciplinary team to ensure successful results. The prosthodontic treatment outcome is one of the most important parameters by which a patient measures the restoration of aesthetic, functional, and psychological deficits. This study is a retrospective review: twenty-two patients diagnosed with outcomes of ballistic traumas were identified from the department database, and eleven patients met the inclusion criteria and were enrolled.

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“…Furthermore, any urgent need to begin systemic therapy or local palliative treatment and pain control must be considered, and the risk factors of MRONJ must be defined. Indeed, the safety profile of aminobisphosphonate, RANK-L ligand, and antiangiogenic agents showed that the exposure to chronic treatment could cause MRONJ, a significant adverse event that has an impact on patients’ quality of life [ 22 , 23 ]. The risk of osteonecrosis could be minimized by the complete removal of the predisposing factors and any possible triggers in the subsequent course of bone therapy [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

A New Medical Record Proposal to the Prognostic Risk Assessment for MRONJ in Oncologic Patients: “Sapienza Head and Neck Unit” Proposal

Brauner

Mezi

Ciolfi

et al. 2021

IJERPH

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: Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event associated with antiresorptive and antiangiogenic drugs. The use of these drugs in the treatment of cancer patients with bone metastasis is necessary and standardized in the literature. A multidisciplinary approach for the patient’s management is strongly recommended. Therefore, it should be necessary to integrate the path of these subjects with a dedicated dental screening in order to first assess the individual risk of developing a MRONJ, and then to plan dental treatments and oral hygiene sessions, and finally to schedule a follow-up to intercept and treat early osteonecrosis. The aim of this manuscript is to propose a new simple medical report to evaluate patients affected by metastatic bone cancer in order to reduce the risk of developing MRONJ.

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Giant Cell Lesion or Langerhans' Cell Histiocytosis of the Mandible? A Case Report

Cited by 6 publications

References 10 publications

Nutrition and Cancer Prevention

Nutrition and Cancer Prevention

Dental Management of Maxillofacial Ballistic Trauma

A New Medical Record Proposal to the Prognostic Risk Assessment for MRONJ in Oncologic Patients: “Sapienza Head and Neck Unit” Proposal

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