Giant cell reaction to ameloblastoma: An immunohistochemical and ultrastructural study of a case

Kawakami, Toshiyuki; Antoh, Motoyoshi; Minemura, Toshikazu

doi:10.1016/s0278-2391(89)80017-5

Cited by 20 publications

(9 citation statements)

References 12 publications

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“…They supported their position by noting the development of aneurysmal bone cysts in association with intraosseous lesions, as well as the giant cell reaction adjacent to ameloblastomas [11,12]. Also, CGCL have been reported in association with central ossifying fibroma [13] and they can be rarely encountered with different types of benign fibro-osseous lesions [personal observation, unpublished data].…”

Section: Discussionmentioning

confidence: 84%

“…Finally, Kessler presented a case diagnosed as central odontogenic fibroma with central giant cell granuloma in the 2006 Meeting of the Western Society of Teachers of Oral Pathology bringing the total number of reported patients, known to the authors, to 16. Also there are reports associating CGCL with ameloblastoma, and non-odontogenic fibro-osseous lesions [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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So-called Hybrid Central Odontogenic Fibroma/Central Giant Cell Lesion of the Jaws. A Report on Seven Additional Cases, Including an Example in a Patient with Cherubism, and Hypotheses on the Pathogenesis

Tosios

Gopalakrishnan

Koutlas

2008

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

So-called Hybrid Central Odontogenic Fibroma/Central Giant Cell Lesion of the Jaws. A Report on Seven Additional Cases, Including an Example in a Patient with Cherubism, and Hypotheses on the Pathogenesis

Tosios

Gopalakrishnan

Koutlas

2008

Head and Neck Pathol

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“…[ 16 ] gave a detailed microscopic description of eight patients with ‘hybrid central giant cell granuloma and central odontogenic fibroma-like’ lesions. There are also reports of CGCL with ameloblastoma, and several non-odontogenic fibro-osseous lesions [ 17 , 18 ]. Although the case series reported by Dayan et al .…”

Section: Discussionmentioning

confidence: 99%

A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report

Ogbureke¹,

Vigneswaran

Seals³

et al. 2015

J Med Case Reports

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IntroductionPeripheral giant cell granuloma and peripheral ossifying fibroma are clinicopathologically distinct gingival lesions. Both are included in clinical differential diagnoses of common benign and reactive gingival epulides in humans. It is often impossible to make a clinical distinction between the two entities, thereby making definitive diagnosis dependent on histopathologic features. While our search of the English literature revealed several reports of peripheral giant cell granuloma with ‘bone formation’, we were unable to identify any reports of hybrid peripheral ossifying fibroma-peripheral giant cell granulomas.Case presentationWe report a case of a 44-year-old Caucasian man presenting with a three-month history of swelling of his right posterior mandible, related to an area of previous dental implant restoration. A clinical examination revealed modest extraoral facial swelling of his right posterior mandible, while an intraoral examination showed a 45×25×15mm sessile, lobular soft tissue mass of the right posterior mandibular gingiva. The mucosal covering of the lesion exhibited focal surface ulceration. A panoramic radiograph showed two implants at the vicinity of the lesion with no other significant findings. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed salient and distinctive features of peripheral giant cell granuloma and of peripheral ossifying fibroma, estimated at near equal proportions. This raises the possibility of a hybrid odontogenic lesion.ConclusionThe presentation of this lesion, with areas of peripheral giant cell granuloma along with a distinct area of extensive osseous formation and stroma reminiscent of a peripheral ossifying fibroma, justifies consideration of this as a possible hybrid lesion. Although the biologic behavior of a combined lesion is not anticipated to deviate significantly from that of either of the single entities, this case resurrects an enduring debate as to whether peripheral giant cell granuloma and peripheral ossifying fibroma are simply parts of a disease spectrum, or whether some of these lesions represent true hybrid lesions. It is therefore recommended that more cases with histopathologic features similar to the lesion in our case be reported in the literature to further elucidate the histogenesis of these lesions.

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“…Dysplastic dentin or cystic-like characteristics, however, are absent [17]. Rarely, CGCL have also been identified in proximity to other odontogenic lesions including ameloblastoma [28,29] and keratocystic odontogenic tumor (KCOT, odontogenic keratocyst) [30], probably representing an epiphenomenon.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic and Molecular Characteristics of Familial Cherubism with Associated Odontogenic Tumorous Proliferations

Argyris

Gopalakrishnan

et al. 2017

Head and Neck Pathol

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Cherubism is a rare autosomal dominant condition affecting the jaws and caused by mutations in the gene encoding for the adapter protein SH3BP2 that maps to chromosome 4p16.3. Cherubism is characterized by symmetrically developing bone lesions in the maxilla and mandible. The lesions have been radiographically and histopathologically well-described. Here, we present a family with cherubism with two of its members featuring odontogenic tumorous proliferations in association with persistent central giant cell lesions (CGCL). Specifically, the proband, a 25-year-old male, developed a radiolucent lesion characterized histologically by central odontogenic fibroma-like proliferation in association with a CGCL component, while his mother, at age 57, was diagnosed with primary intraosseous odontogenic carcinoma with areas of benign fibro-osseous lesions. In both patients the lesions occurred in the anterior mandible and presented with clinical enlargement. The son underwent incisional biopsy and did not have additional treatment. His mother underwent extensive mandibulectomy due to widespread tumor. The son has two affected children with classic cherubism while a third child at age 5, had not shown any features of the disease. Mutation analysis of three affected members resulted in the identification of a heterozygous mutation in SH3BP2 (c.1244G>C; p.Arg415Pro). To the best of our knowledge, association of cherubism with odontogenic neoplastic lesions has hitherto not been reported in the literature, thus suggesting a relationship between cherubism with disturbed odontogenesis.

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Giant cell reaction to ameloblastoma: An immunohistochemical and ultrastructural study of a case

Cited by 20 publications

References 12 publications

So-called Hybrid Central Odontogenic Fibroma/Central Giant Cell Lesion of the Jaws. A Report on Seven Additional Cases, Including an Example in a Patient with Cherubism, and Hypotheses on the Pathogenesis

So-called Hybrid Central Odontogenic Fibroma/Central Giant Cell Lesion of the Jaws. A Report on Seven Additional Cases, Including an Example in a Patient with Cherubism, and Hypotheses on the Pathogenesis

A peripheral giant cell granuloma with extensive osseous metaplasia or a hybrid peripheral giant cell granuloma-peripheral ossifying fibroma: a case report

Clinicopathologic and Molecular Characteristics of Familial Cherubism with Associated Odontogenic Tumorous Proliferations

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