Giant-cell tumor in soft parts in a patient with osseous Paget's disease: Diagnosis by fine-needle aspiration

Abstract

In this report, the cytological features and differential diagnosis of a case of giant‐cell tumor (GCT) in soft tissues in a patient with osseous Paget's disease (PD) are described, with histological confirmation. Characteristic cytological findings include a diffuse cellular population of neoplastic cells composed of two types: one group of polygonal or round mononuclear small cells, exhibiting a thin‐rim, dense cytoplasm and single hyperchromatic nuclei; and the second group of multinucleated, osteoclast‐type giant cells with dozens of round nuclei, showing occasional micronucleoli. A prominent feature is the presence of numerous capillary structures surrounded by tumor cells. The differential diagnosis includes a number of other neoplastic and reactive processes in which giant cells may be abundant. The cytological features of GCT appear to be characteristic enough to allow a suggestive diagnosis. However, the final diagnosis should be made only after the lesion has been studied histologically. Diagn. Cytopathol. 1998;19:352–354. © 1998 Wiley‐Liss, Inc.

Primary giant cell tumor of soft tissues similar to bone giant cell tumor: A case report and literature review

“…In our opinion, our case is similar to the 77 previously reported cases 8–14 of primary GCT of soft tissue. In all cases, radiography and/or computed tomography scan showed no connection with the nearby bone, and surgery confirmed the extraosseous location.…”

“…Although our patient did not present this feature, metaplastic bone trabeculae are a frequent event in GCT of soft tissue, and their pathogenesis has been discussed by Teot et al 9 Thirty-four of the 78 (43.5%) reported GCT of soft tissue showed scattered bony structures or even an incomplete bony shell of metaplastic bone trabeculae, mainly located at the margin of the tumor. [8][9][10][12][13][14] Vascular invasion, a recently described feature in 18 of 64 (28%) cases, [12][13][14] was not observed in our case.…”

“…The lesions ranged from 1 to 10 cm in diameter. Only the case described by Galed‐Placed et al 10 was larger, measuring 20 × 8 cm. Tumors tended to be superficial (63%) and multi‐nodular.…”

“…However, a series 8 and one case report 9 of primary GCT, similar to the bone counterpart, have been reported in soft tissues. Moreover, another two cases of GCT with a controversial origin have been recently described, in a patient with soft tissue tumor of the buttock and Paget's disease, 10 and in a 24‐year‐old woman with a spinal sacral canal involvement 11 . However, three more recent series 12–14 with 64 new cases have clearly delineated this entity.…”

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soft tissue tumor of the buttock and Paget's disease, 10 and in a 24-year-old woman with a spinal sacral canal involvement. 11 However, three more recent series [12][13][14] with 64 new cases have clearly delineated this entity.

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