Giant Cell Tumor of Bone - an Analysis of 62 Cases

Giant cell tumor of bone: treatment and outcome of 214 cases

“…The high local recurrence rate in curettage without adjunct was already described in previous studies (Goldenberg et al 1970;Lausten et al 1996;Masui et al 1998;Persson et al 1984;Tunn and Schlag 2003;Wuisman et al 1989). This is most likely due to the incomplete tumor removal.…”

“…Therefore the standard procedure is accurate intralesional curettage with additional adjuncts for eradication of remaining tumor cells. This can be accomplished by physical adjuncts such as cryotherapy, hyperthermia or high-speed burring (Blackley et al 1999;Demichev 1994;Fan et al 1996;Malawer et al 1999;Malek et al 2006) or chemical substances with cytotoxic eVects such as phenol, alcohol, H 2 O 2 or methotrexate (Blackley et al 1999;Durr et al 1999;Goldenberg et al 1970;Jones et al 2006;Kirchen et al 1996;Lausten et al 1996;Masui et al 1998;Nicholson et al 1998;Ritschl et al 1989;Rooney et al 1993;Schiller et al 1989;Schwartz 1998;Szendroi 1992;Trieb et al 2001;Wuisman et al 1989). Bone cement reveals both eVects: physical via thermal necrosis (Leeson and Lippitt 1993;Mjoberg et al 1984) and cytotoxic via free radicals (Nelson et al 1997).…”

“…There is a vast number of surgical procedures on GCTB ranging from intralesional curettage to wide resection Lausten et al 1996;Persson et al 1984;Ward and Li 2002;Wuisman et al 1989). Although wide resection leads to the lowest local recurrence rates it can not be recommended as standard treatment (Liu and Wang 1998).…”

Management of grade III giant cell tumors of bones

“…In reviewing the literature, we observed that the rate of local recurrence in intralesional excisions ranges from 20% to 50% without adjuvant modality, a decrease of about one-half to three-quarters in contrast to using adjuvant modalities [6,[9][10][11][12][13][14][15][16]. The role of the local adjuvant agent was to eradicate any remaining tumor cells, but it is difficult to say which one is best clinically.…”