Giant cell tumor of bone: a report of two cases with metaphyseal lesions and their progression to the articular surface

Test yourself answer to question: a 26-year-old female presenting with a 5-month history of insidious onset medial right knee pain

“…Although GCT usually arises in the epiphyses of long bones, purely epiphyseal GCT at presentation is reported to be low, as they are more commonly found with metaphyseal extension. A small number of non-epiphyseal GCT have described [4][5][6][7], with ~ 0.8% of cases being metaphyseal or diaphyseal [5]. The initial site of origin is unclear, although a metaphyseal origin has recently been suggested [8].…”