Giant cell tumor of soft tissue arising in breast

May, Steve A.; Deavers, Michael T.; Resetkova, Erika; Johnson, Deborah; Albarracin, Constance T.

doi:10.1016/j.anndiagpath.2006.03.013

Cited by 22 publications

(32 citation statements)

References 9 publications

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“…SMA expression has also been noted in giant cell tumours of soft tissue, skin and other extraskeletal sites [23][24][25]. In contrast to previous studies [13,22], we did not identify actin expression by giant cells in GCTB or other giant cell-rich lesions of bone, although we did note that the giant cells in these lesions were often surrounded by thin-walled vessels or MSC expressing SMA and muscle-specific actin.…”

Section: Discussioncontrasting

confidence: 85%

Smooth muscle actin expression in primary bone tumours

et al. 2012

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Alpha isoform of smooth muscle actin (SMA) expression has been reported in giant cell tumour of bone (GCTB) and other benign and malignant bone tumours, but the pattern of SMA expression and the precise nature of SMA-expressing cells in these lesions is uncertain. We determined by immunohistochemistry the expression of SMA and other muscle and vascular markers in normal bone, GCTB and a wide range of primary benign and malignant bone tumours. Cultured stromal cells of GCTB, chondroblastoma (CB), and aneurysmal bone cyst (ABC) were also analysed for SMA expression. SMA was only noted in blood vessels in normal bone. SMA was expressed by mononuclear stromal cells (MSC) cultured from GCTB, ABC and CB. SMA was strongly and diffusely expressed by MSC in non-ossifying fibroma, fibrous dysplasia, and "brown tumour" of hyperparathyroidism. SMA expression was also noted in GCTB, ABC, CB, chondromyxoid fibroma, malignant fibrous histiocytoma of bone and osteosarcoma. Little or no SMA was noted in Langerhans cell histiocytosis, simple bone cyst, Ewing's sarcoma, osteoblastoma, osteoid osteoma, enchondroma, osteochondroma, chondrosarcoma, myeloma, lymphoma, chordoma and adamantinoma. Our findings show that there is differential SMA expression in primary bone tumours and that identifying the presence or absence of SMA is useful in the differential diagnosis of these lesions. The nature of SMA-expressing cells in bone tumours is uncertain but they are negative for desmin and caldesmon and could represent either myofibroblasts or perivascular cells, such as pericytes.

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Section: Discussioncontrasting

confidence: 85%

Smooth muscle actin expression in primary bone tumours

et al. 2012

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“…10 Chand et al reported that none of the cases they reported was clinically suspected as GCT-ST in keeping with our experience. They present frequently as skin tumour and may be superficial as the case presented, or may be in deep body tissue.…”

Section: Discussionsupporting

confidence: 76%

Giant cell tumor of right thumb: a rare case report

et al. 2015

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“…The differential diagnosis includes metaplastic carcinoma with osteoclastic giant cells 6–8 and giant cell tumor of soft tissue 9–11 . Neoplastic and reactive giant cells can coexist in carcinoma of the breast.…”

Section: Discussionmentioning

confidence: 99%

“…Giant cell tumor of soft tissue arising in breast is very rare. So far only three cases have been reported 9–11 . Histologically tumor is composed predominantly of mononuclear cells admixed with osteoclastic giant cells.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic carcinoma with osteoclastic giant cells of the breast: Immunohistochemical differentiation between coexisting neoplastic and reactive giant cells

Kurokawa

Mouri

Asano³

et al. 2009

Pathology International

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Herein is described a unique case of breast carcinoma with two different types of giant cells noted in both cytological and histological specimens. A 51-year-old Japanese woman noticed a hard mass in the upper outer quadrant of her left breast. Aspiration cytology exhibited numerous anaplastic giant cells; the cytological diagnosis was high-grade ductal carcinoma, although a few osteoclastic giant cells were also observed. A left simple mastectomy and sentinel lymph node biopsy were performed. Histologically, approximately 90% of the tumor was composed of giant cells; conventional invasive ductal carcinoma and ductal carcinoma in situ were found focally at the periphery of the tumor. The main part of the tumor contained both anaplastic, neoplastic giant cells and non-neoplastic, osteoclastic giant cells that were distinguishable from nuclear atypism. The presence of the two types of giant cells was also confirmed on immunohistochemistry using a histiocytic marker (CD68) and two epithelial markers (AE1/AE3 and CAM5.2). Based on the latest World Health Organization classification, the diagnosis was pleomorphic carcinoma with osteoclastic giant cells. To the authors' knowledge there has been no previous report on this subject except for a single case mentioned in Rosen's Breast Pathology.

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Giant cell tumor of soft tissue arising in breast

Cited by 22 publications

References 9 publications

Smooth muscle actin expression in primary bone tumours

Smooth muscle actin expression in primary bone tumours

Giant cell tumor of right thumb: a rare case report

Pleomorphic carcinoma with osteoclastic giant cells of the breast: Immunohistochemical differentiation between coexisting neoplastic and reactive giant cells

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