Giant cell tumor of tendon sheath: Cytomorphologic and radiologic findings in 41 patients

Ho, Cheng Ying; Maleki, Zahra

doi:10.1002/dc.22840

Cited by 29 publications

(37 citation statements)

References 16 publications

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“…L-GCTTS primarily occurs in the tendon sheaths of the hand and foot and exhibits clear boundaries, whereas D-GCTTS occurs in large joints with a more aggressive growth pattern and associated high recurrence rate (2). As magnetic resonance imaging (MRI) can be used to characterize and estimate the extent of soft tissue tumors, this imaging technique is currently the method of choice for the diagnosis of GCTTS (3). Certain studies have investigated the use of MRI for the diagnosis of L-GCTTS (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…As magnetic resonance imaging (MRI) can be used to characterize and estimate the extent of soft tissue tumors, this imaging technique is currently the method of choice for the diagnosis of GCTTS (3). Certain studies have investigated the use of MRI for the diagnosis of L-GCTTS (3)(4)(5). However, few studies have exclusively clarified the characteristic MRI features of L-GCTTS and D-GCTTS.…”

Section: Introductionmentioning

confidence: 99%

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Giant cell tumor of the tendon sheath: Magnetic resonance imaging findings in 38 patients

et al. 2017

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Abstract. The present study aimed to investigate the value of magnetic resonance imaging (MRI) in the diagnosis of giant cell tumor of the tendon sheath (GCTTS), including localized (L-) and diffuse (D-) types. A total of 38 patients with GCTTS, including 31 with L-GCTTS and 7 with D-GCTTS, diagnosed by surgery and pathology, were retrospectively analyzed. All patients underwent MRI examination. Of the 31 patients with L-GCTTS, the tumors were located in the hand and wrist (18 patients), the ankle and foot (10 cases), the knee joint (2 cases) and the temporomandibular joint (1 case). All 31 lesions were either located in relation to a tendon or were partially/completely enveloping it and all were well marginated. With respect to the 7 D-GCTTS patients, the tumors were located in the ankle and foot (6 cases) or the hand and wrist (1 cases). All 7 lesions presented as an aggressive soft tissue mass infiltrating the tendon sheath and adipose tissue around the joint. The characteristic internal signal of GCTTS, including L-GCTTS and D-GCTTS, was demonstrated by MRI examination. MRI is currently the optimal modality for preoperative assessment of tumor size, extent and invasion of adjacent joint and tenosynovial space.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Giant cell tumor of the tendon sheath: Magnetic resonance imaging findings in 38 patients

et al. 2017

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“…The cell components of D-GCTS include the large synovial-like mononuclear, small histiocytoid, foamy histiocyte and inflammatory cells, fibroblasts and the osteoclast-like multinucleated giant cells (5,24,25). The number of large synovial-like mononuclear cells that are positive for clusterin in D-GCTS are more than that in L-GCTS (P<0.01) and PVNS (P<0.05) (26).…”

Section: Discussionmentioning

confidence: 99%

Diffuse-type giant cell tumor of the tendon sheath in the temporal region incidentally diagnosed due to a temporal tumor: A report of two cases and review of the literature

Qin

Jin

et al. 2015

Oncology Letters

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Abstract. Diffuse-type tenosynovial giant cell tumor (D-GCTS) is a rare benign lesion that not only frequently occurs in the fingers, but also along the tendon sheaths of the foot and ankle. The present study reports the cases of two middle-aged patients that were diagnosed with D-GCTS. The presentation of the D-GCTS lesions was extremely rare, as the tumors were located in the temporal fossa and threatened the skull base and external auditory canal. There were similarities and differences between the two patients in their clinical symptoms, disease progressions and invading sites. The patients' disease course occurred unnoticed with the absence of pain, was protracted and became infiltrative. However, the female patient was admitted to the hospital due to the occurrence of pain in the left temporal region, and the male patient presented at the doctor due to a painless left temporal mass and external auditory canal bleeding. Therefore, the operation area of the two patients was not the same. This type of illness should be considered in the differential diagnosis for masses occurring in the temporal region. Total tumor removal is the best treatment for D-GCTS, and the careful monitoring of recurrence can achieve a good clinical outcome subsequent to the surgical resection. IntroductionGiant cell tumor of the tendon sheath (GCTS) was initially described by Chassaignac in 1852 (1), and the lesion was defined as a malignant tumor at that time (2). Subsequently, Heurteux produced a detailed description of GCTS (3). It was found that the disease occurs more frequently in middle-aged women compared with men (4). According to the position (large or facet joint; intra-or extra-articular), characteristics (benign or malignant) and growth pattern (diffuse or localized) of the tumor, GCTS may be classified as one of four types: Localized-type tenosynovial giant cell tumor (L-GCTS); diffuse-type tenosynovial giant cell tumor (D-GCTS); pigmented villonodular synovitis (PVNS) (5,6); and malignant tenosynovial giant cell tumor (M-GCTS) (7,8).D-GCTS demonstrates invasive growth in the local region, which is considerably different from L-GCTS. D-GCTS usually develops in the synovium, and often invades the surrounding knee and soft tissue (2,9). Since it arises mainly from the soft tissue outside the joints, Weiss et al (10) regarded D-GCTS as a type of PVNS that appears in the soft tissue outside the joints, and also presents with intra-articular lesions (2,5). L-GCTS mainly occurs in the small joints, including the hand, foot and ankle. Image findings in previous studies reveal these soft tissue masses occur beside small joints (9,11). If the results of image analysis demonstrate that the lesions have invaded the joints, and if there is a concurrent weak signal of T1W and T2W on a magnetic resonance imaging (MRI) scan, D-GCTS should be considered as a probable diagnosis (12-15).GCTS usually occurs in individuals between the ages of 30 and 50 years (5). As a painless and slow-growing disease, it has been termed an innocent tumor ...

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“…Current studies are limited to small retrospective series with a varying range (44-74%) of results for location (volar versus dorsal side) (7,(10)(11)(12)(13). A recent systematic review by Fotiadis et al did not look into volar versus dorsal location of GCTTS on digits (2).…”

Section: Discussionmentioning

confidence: 99%

Giant Cell Tumor of the Tendon Sheath

小山田¹,

北島²,

米田³

et al. 2011

Imaging of Pain

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IntroductionG iant cell tumor of tendon sheath (GCTTS) and ganglion cyst are the most common benign tumors of the hand (1, 2). In general GCTTS can present as a solitary subcutaneous nodule of the hand, but it can also occur in other parts of the body such as the spine, ankle, knee and feet (3, 4). However, with an approximate incidence of 1/50,000 per population it remains an uncommon condition (5). The incidence of GCTTS is higher in women than in men and mostly seen in the third to fifth decade (3, 6).The results of previous research are inconsistent regarding whether GCTTS is more often volar or dorsal in the hand, with a tendency for it to occur more often on the volar aspect of the hand (7-10). The occurrence of a volarsided GCTTS has been reported to range between 44 and 76% (7-11). The purpose of this study was to examine a large series of GCTTS in the hand to further assess the relative frequency of dorsal and volar GCTTS. We hypothesized that GCTTS are equally common on the dorsal and volar aspects of the hand. In addition, we hypothesized that there are no factors (i.e., demographic, clinical and pathological) associated with the location (volar versus dorsal side) and largest measured diameter of a GCTTS. Materials and MethodsUnder an IRB approved protocol 278 patients that had operative treatment of a GCTTS between January 2002 and November 2012 were identified using a database of pathology reports. The study was performed in a single tertiary care hospital and the procedures were performed by four experienced hand surgeons. Informed consent was waived for this medical record study. The medical records of all patients aged 18 years or older with a pathologically confirmed GCTTS of the finger or hand were reviewed retrospectively. Pregnant women (IRB mandated) and patients with a recurrence of a GCTTS already surgically treated in our center were excluded. We recorded sex, age, side, dorsal or volar location, finger or hand location and largest measured diameter of the GCTTS. The diameter was obtained from the pathology report. Giant Cell Tumor of Tendon SheathAbstract Background: Giant cell tumor of tendon sheath (GCTTS) is often thought of as a volar finger mass. We hypothesized that GCTTS are equally common on the dorsal and volar aspects of the hand. In addition, we hypothesized that there are no factors associated with the location (volar versus dorsal) and largest measured dimension of a GCTTS.

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Giant cell tumor of tendon sheath: Cytomorphologic and radiologic findings in 41 patients

Cited by 29 publications

References 16 publications

Giant cell tumor of the tendon sheath: Magnetic resonance imaging findings in 38 patients

Giant cell tumor of the tendon sheath: Magnetic resonance imaging findings in 38 patients

Diffuse-type giant cell tumor of the tendon sheath in the temporal region incidentally diagnosed due to a temporal tumor: A report of two cases and review of the literature

Giant Cell Tumor of the Tendon Sheath

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