Giant Cell Tumor of the Frontal Bone Presenting as an Orbital Mass

Tang, Peter H.; Mettu, Priyatham S; Maltry, Amanda C.; Harrison, Andrew R.; Mokhtarzadeh, Ali

doi:10.1007/s40123-017-0081-y

Cited by 9 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonspecific findings of GCTB may include an enhancing, well-circumscribed lesion with low-to-intermediate signal intensity on T1-weighted images and intermediate-to-high intensity on T2-weighted images. 9 On CT imaging, GCTB tends to demonstrate a radiolucent, osteolytic lesion with well-demarcated margins. Differential diagnosis of this orbit tumor included: osteosarcoma, intraosseous hemangioma, osteoma, Langerhans cell histiocytosis, and metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Giant Cell Tumor of Bone, Rare Inferior Orbit Location

Garcia,

Bryson,

Mansueto

2024

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Summary: Giant cell tumor of bone (GCTB) typically presents in the epiphysis of long bones and occurs in the skull in less than 1% of cases. When GCTB is diagnosed in the skull, it is primarily seen in the temporal and sphenoid bones. GCTB is an osteoclastic stromal tumor that is locally aggressive and tends to recur. We present a case of a 43-year-old woman with slowly progressive, left-sided proptosis, eyelid swelling, photophobia, epiphora, and pressure sensation. Computed tomography and magnetic resonance imaging revealed an enhancing tumor in the left inferior orbit with infiltration into the maxillary sinus roof. Histological examination was conclusive for a giant cell tumor of the maxillary bone presenting as an inferior orbital mass. Gross total surgical resection was performed via an inferior anterior orbitotomy, and the patient had resolution of symptoms without recurrence in her postoperative course to date. This report contributes to the scarce literature available on this type of tumor of skull bones, specifically presenting the first case in the maxillary bone of the floor of the orbit.

show abstract

Section: Discussionmentioning

confidence: 99%

Giant Cell Tumor of Bone, Rare Inferior Orbit Location

Garcia,

Bryson,

Mansueto

2024

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

“…[ 8 ] The MRI features of giant cell tumor of bone are nonspecific, usually demonstrating a well-circumscribed lesion with low to intermediate signal intensity or isointense on T1-weighted images; intermediate to high intensity or hypointense on T2-weighted images; and homogenous enhancement after gadolinium injection. [ 8 9 10 11 ] However, there are no MRI features sufficiently characteristic to allow a preoperative diagnosis of giant cell tumor of bone especially those in the rare locations. [ 8 12 ] Due to the small number of skull-base giant cell tumors reported in the literature, standard treatments have yet to be established.…”

Section: Discussionmentioning

confidence: 99%

Left orbital roof giant cell tumor of bone: A case report

Yip¹,

Lee²,

Hsu³

et al. 2018

Surg Neurol Int

View full text Add to dashboard Cite

Background:Giant cell tumor of bone originating from the connective tissue within the bone marrow is benign but locally aggressive lesion. In all, 90% of the cases involve the epiphysis of long bones and less than 2% involve the skull. Giant cell tumors of the skull occur most frequently in the sphenoid and temporal bones, and very rarely in the ethmoid, frontal, parietal, and occipital bones. We would like to share a case of giant cell tumor of bone arising from the left orbital roof with involving ethmoid sinus, which was diagnosed to be a meningioma before surgery.Case Description:A 32-year-old lady presented to us with the chief complain of left proptosis, diplopia, and left eye soreness without decline of visual acuity for about 2 months. Her orbital magnetic resonance imaging (MRI) disclosed a mass lesion located in the left frontal base, orbital roof, and upper medial orbital region with adjacent dural-tail sign favoring meningioma. She underwent a left supraorbital pterional craniotomy with the gross total removal of tumor and dura reconstruction. Histology examination of the tumor showed a picture of giant cell tumor of bone. Considering giant cell tumor of bone is locally aggressive, postoperative adjuvant therapy with Denosumab was introduced after full explanation.Conclusion:Standard treatments of skull-base giant cell tumors have yet to be established due to small number of cases reported in the literature. The standard treatment of giant cell tumor of bone is complete resection of the tumor.

show abstract