Giant cell tumor of the temporal bone – a case report

Pai, S. Balaji; Lalitha, R.M.; Prasad, Kavitha; Rao, Saraswathi G; Harish, K

doi:10.1186/1472-6815-5-8

Cited by 33 publications

(31 citation statements)

References 21 publications

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“…1,6,7 On reviewing the available literature, some individual cases were excluded according to the reclassification of giant cell reparative granuloma (GCRG) by Hirschl and Katz in 1974. 8 One hundred and ten GCTs of the skull, including Mayo's series, 10 reviews 3,5,7,[9][10][11][12][13][14][15] and cases reported by otorhinologists, [16][17][18][19][20][21][22][23][24] showed that the sphenoid (52 cases) and temporal bones (40 cases) were the most common sites in the skull. GCTs involving the cranial vault (18 cases) are much rarer, and sometimes occur in association with Paget's disease.…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of the temporal bone with intratumoral hemorrhage

Matsushige

Nakaoka

Yahara

et al. 2008

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Giant cell tumor of the temporal bone with intratumoral hemorrhage

Matsushige

Nakaoka

Yahara

et al. 2008

Journal of Clinical Neuroscience

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“…Posterior extensions into the PCF, though rare, can be aggressive and extremely challenging to treat as seen in case 5 of our series. The reports of GCTs by other authors [Cook et al, 1986;Findlay et al, 1987;Rock et al, 1994;Saleh et al, 1994;Silvers et al, 1996;Lee and Lum, 1999;Gibbons et al, 2000;Tang et al, 2003;Pai et al, 2005;Elder et al, 2007;Matsushige et al, 2008;Isaacson et al, 2009;Iizuka et al, 2012] show that most authors achieved radical tumor removal through lateral skull base or neurosurgical procedures with adequate locoregional control ( table 2 ). The facial nerve and the lower cranial nerves were preserved during surgery in all our cases.…”

Section: Surgical Managementmentioning

confidence: 99%

Giant Cell Tumors of the Skull Base: Case Series and Current Concepts

Prasad

Piccirillo²,

Nuseir

et al. 2013

Audiol Neurotol

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Objective: To study the clinical features, tumor characteristics and outcomes of giant cell tumors (GCTs) in the skull base based on long-term follow-up. We also report the largest series of GCTs in the temporal bone and the lateral skull base. Materials and Methods: A retrospective study was conducted of all GCTs managed at the Gruppo Otologico, a quaternary referral skull base institute, in Italy from 1993 to 2013. The clinical features, investigations, surgical management and follow-up were recorded. The surgical approaches used were infratemporal fossa approach (ITFA) type B and D and middle cranial fossa (MCF) approaches. Results and Observations: A total of 7 patients with GCTs of the skull base were treated at our institution. The principal complaints were hearing loss reported in 6 (85.71%) patients, tinnitus in 5 (71.43%) and swelling in 3 (42.9%). Pure-tone audiometry showed conductive hearing loss in 5 (71.43%) patients. High-resolution CT scan and MRI with gadolinium enhancement were done in all patients. Radiology showed involvement of the ITF and middle ear in 6 (85.71%) patients each, temporomandibular joint in 4 (57.14%) patients, invasions of the squamous part of the temporal bone, mastoid, MCF and greater wing of sphenoid in 3 (42.9%) patients each and the petrous bone in 2 (28.6%) patients. ITFA type B was applied as an approach for tumor removal in 5 (71.43%) patients, including a case where an additional MCF approach was employed, and ITFA type D and the transmastoid approach were applied in 1 (14.3%) patient each. Total tumor removal and successful cure was achieved in 6 (85.71%) patients. Subtotal removal leading to recurrence and eventual mortality was the result in 1 (14.3%) patient. Conclusions: A thorough knowledge of the anatomy of the skull base and the various skull base approaches is necessary to tackle GCTs. ITFA type B and D combined with MCF approaches provide good exposure of the tumor with minimal postoperative sequelae and good locoregional control. Recurrence due to either subtotal removal or suboptimal treatment may have disastrous consequences for the patient.

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“…Giant cell tumor of bone is a benign lesion that is usually solitary and locally aggressive. 6 Most patients present with slowly progressive pain with or without a mass. Hearing loss, pain and cranial nerve paralysis of the facial nerve are the common presenting complaints.…”

Section: Discussionmentioning

confidence: 99%