Giant Cell Tumor of the Larynx

Murrell, George L.; Lantz, H. Joseph

doi:10.1177/014556139307200512

Cited by 13 publications

(12 citation statements)

References 3 publications

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“…In most instances, the giant cell component has an osteoclast-like appearance and is related to stromal hemorrhage. This situation has been reported in thyroid gland [6], pancreas [7], liver [12], gall bladder [8], salivary glands [5], colon [4], ovary [17], kidney [3], renal pelvis [11], urinary bladder [10], breast [19], and larynx [16]. In other cases, often from lung origin [1,2,9,15] but also occurring in pancreas [13], urinary bladder [10], and other sites, the giant cells are neoplastic and are associated with poor differentiation and dismal prognosis.…”

Section: Introductionmentioning

confidence: 60%

“…Hemorrhage-associated osteoclast-like giant cells have been reported in carcinomas from different organs [4,5,6,7,8,9,11,12,15,16,17,19] and this feature does not bear any relationship with outcome. Conversely, giant cells of epithelial origin found in carcinomas, particularly from lung, pancreas or urinary bladder [1,2,10,13], are indicative of a high degree of anaplasia and poor prognosis.…”

Section: Discussionmentioning

confidence: 97%

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Renal cell carcinoma with syncytial giant cell component

et al. 2001

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We report a case of clear cell renal cell carcinoma in which a prominent multinucleated giant cell component was intermingled with clear, granular, and spindle cells. Histological, ultrastructural, cytometric, and cytogenetic features of giant cells were similar to those of mononucleated cells in the tumor, and therefore they were not from stromal or osteoclast derivation. These giant cells had homogeneous, finely granular, abundant cytoplasm, often with scalloped cell borders, and contained from 5 to more than 50 nuclei, all of them very similar in size and shape, with prominent central nucleoli. Occasionally, surrounding inflammatory cells were also engulfed in the cytoplasm. This syncytial appearance was more similar to that of some giant cell carcinomas from the lung than to the pleomorphic giant cells often encountered in high grade renal cell tumors. Although the patient is alive and free of disease 6 years after diagnosis, a longer follow-up will be required to assess the potential prognostic influence of this peculiar histological appearance.

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 97%

Renal cell carcinoma with syncytial giant cell component

et al. 2001

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“…Wessely 4 Federova 5 Wagemann 6 Perrino 7 Kaliteevskii and Korol'kova 8 Pohl 9 Kohn 10 Rudert 3 Hall-Jones 11 Goto and Nakashima 12 Kotarba and Niezabitowski 13 Ribarietal 14 Kubo et al 15 Tsybyme and Bogdanskaia 16 Borghese et al 17 Murrell and Lantz 18 Martin et al 19 resented a metastasis from a femoral primary and was not included. This leaves a total of 19 cases, including the present one (see Table 219 ).…”

Section: Authorsmentioning

confidence: 99%

Giant Cell Tumor of the Larynx

Hinni¹

2000

Ann Otol Rhinol Laryngol

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Giant cell tumors are benign tumors generally found in the long bones. Very rarely, they can occur in the larynx and may present with dysphonia, dysphagia, or dyspnea. A case of giant cell tumor of the larynx was recently identified and successfully treated by a partial laryngectomy. A literature review has revealed 18 case reports of giant cell tumor of the larynx. All cases occurred in men. These 19 cases are reviewed, and follow-up data presented where available. There have been no reports of recurrence regardless of treatment, and an excellent prognosis can be expected when one encounters this unusual laryngeal neoplasm.

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“…1,[3][4][5][6] Giant cell tumors (GCTs) are predominantly benign neoplasms of the long bones, most often occurring at the distal femur or proximal tibia. [1][2][3]5,7 Although rare in the head and neck, GCTs have a predilection for areas of endochondral ossification in the base of the skull, namely the sphenoid, ethmoid, and temporal bones. [1][2][3][4][5] GCTs of the larynx, as first reported by Wessely in 1940, 8 are considered to be locally aggressive but benign, and they are exceedingly rare.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] GCTs of the larynx, as first reported by Wessely in 1940, 8 are considered to be locally aggressive but benign, and they are exceedingly rare. [2][3][4][5][6][7] Fewer than 30 cases have been described in the literature, only 1 of which was reported to be malignant. 4,9 Upon further review, several authors have questioned the validity of the malignant designation given to that case.…”

Section: Introductionmentioning

confidence: 99%

Giant Cell Tumor of the Larynx: A Case of Malignant Sarcomatous Transformation

Vivero¹,

Dave²,

Gómez

et al. 2013

Ear Nose Throat J

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We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx. The patient, a 34-year-old man, presented to our tertiary care university teaching hospital where he underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and 11 of 15 cycles of chemotherapy. He remained disease-free at approximately 6 years and 4 months of follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. We discuss the patient's clinical course and subsequent treatment within the context of a review of the current literature regarding this disease entity. Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.

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Giant Cell Tumor of the Larynx

Cited by 13 publications

References 3 publications

Renal cell carcinoma with syncytial giant cell component

Renal cell carcinoma with syncytial giant cell component

Giant Cell Tumor of the Larynx

Giant Cell Tumor of the Larynx: A Case of Malignant Sarcomatous Transformation

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