Giant Cell Tumor of the Larynx: A Clinicopathologic Series of Eight Cases and a Review of the Literature

Wieneke, Jacqueline A.; Gannon, Francis H.; Heffner, Dennis K.; Thompson, Lester D.�R.

doi:10.1038/modpathol.3880462

Cited by 49 publications

(89 citation statements)

References 25 publications

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“…The nuclei of the giant cells are strikingly similar to those of the monuclear cells [2]. Lau et al [4] demonstrated that the mononuclear component of GCT expressed alkaline phosphatase and receptor activator of The head and neck region is an infrequent site for GCTs, which tend to involve the sphenoid, ethmoid and temporal bones [3]. The first case of GCTL was reported by Wesely in 1940 [5][6][7][8].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…The first case of GCTL was reported by Wesely in 1940 [5][6][7][8]. Since then a total of 33 additional cases have been published [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…Six to ten percent of GCTs exhibit malignant features manifesting as high-grade sarcoma occurring at the site of a prior benign GCT or as a sarcoma in juxtaposition to the GCT [2]. No such association has been recorded in the reported cases of GCTL [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature

Yancoskie

Frank

Fantasia

et al. 2015

Head and Neck Pathol

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Section: Discussion and Review Of The Literaturementioning

confidence: 99%

“…The first case of GCTL was reported by Wesely in 1940 [5][6][7][8]. Since then a total of 33 additional cases have been published [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

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Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature

Yancoskie

Frank

Fantasia

et al. 2015

Head and Neck Pathol

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“…Occurrence of the tumors with the same histology is also known in visceral organs, such as the liver, gall bladder, pancreas, salivary gland, thyroid, skin, heart, lung, breast, intestine, larynx, and female genital tract, where they have been termed 'osteoclastoma-like giant-cell tumor' or 'giant-cell tumor.' [1][2][3][4][5][6][7][8][9] To the best of our knowledge, less than 20 case reports (maximum two cases per report) of osteoclast-like giant-cell tumor of the urothelial tract have been published in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Our study is the largest series in the literature of osteoclast-like giant-cell tumors arising in the urinary tract, and includes six patients.…”

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confidence: 99%

Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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Osteoclast-like giant-cell neoplasms of the urinary tract are rare. They are composed of ovoid or spindle-shaped mononuclear cells with evenly spaced osteoclast-like giant cells. Terminology, histogenesis, and biologic behavior of these tumors remain controversial. Six cases of osteoclast-like giant-cell neoplasms of the urinary tract were identified from the consultation files of two of the authors. Patients were all male and elderly (range 65-82), with the exception of one 39-year-old male. In all, 3/6 tumors developed in the bladder and 3/6 in the renal pelvis. Size ranged from 5 to 11 cm. One bladder and three renal pelvis tumors were high stage (pT3) at time of presentation. Adjacent to the osteoclast-like giant-cell neoplasm in the same specimen, all patients had urothelial carcinoma in situ and/or high-grade papillary urothelial carcinoma. Multinucleated cells had identical morphological and immunohistochemical properties of osteoclasts; positive for CD-68, LCA, CD51 and CD54, and negative for cytokeratins and EMA. Varying percentages of mononuclear cells expressed a-smooth muscle actin (4/6), desmin (1/6), S-100 (4/6), LCA (2/6) and CD68 (6/6). However, mononuclear cells were also positive for epithelial markers in 4/6 tumors (cytokeratins AE-1/AE-3, Cam 5.2, CK7 and/or EMA). p53 stained mononuclear tumor cells in three cases, paralleling the staining on the accompanying urothelial carcinoma. Ki-67 stained mononuclear tumor cells, but not osteoclast-like giant cells. Follow-up data were available in five cases. One patient developed recurrence of noninvasive urothelial carcinoma and is still alive. Four patients were dead due to disease within 15 months, three with distant metastases. The intimate association of these tumors with urothelial carcinoma along with their immunohistochemical profile supports an epithelial origin for the mononuclear cells and non-neoplastic reactive histiocytic lineage for the osteoclast-like giant cells.

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“…The differential diagnosis includes a host of entities including giant cell reparative granuloma, brown tumor of hyperparathyroidism, osteoblastoma, chondroblastoma, aneurysmal bone cyst, non-ossifying fibroma, foreign body reaction, benign fibrous histiocytoma, osteosarcoma with abundant giant cells [10].…”

Section: Discussionmentioning

confidence: 99%