Giant cell tumor of the kidney

Kimura, Kakuhei; Ohnishi, Yoshihisa; Morishita, Hideo; Amezaki, Mamoru; Irikura, H

doi:10.1007/bf00583591

Cited by 24 publications

(16 citation statements)

References 22 publications

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“…They display many ultrastructural similarities with osteoclasts, in their content of cell surface processes, Golgi apparatus, lysosomes, clear vacuoles and numerous mitochondria. 12,17 We have also documented that they diffusely express osteoclastic lineage markers of CD51 and CD54. Additional features that suggest that the giant cells in these lesions are not neoplastic are that the giant cells lack cytological atypia, mitotic activity, and immunoreactivity for ki-67 and p53.…”

Section: Osteoclast-like Giant-cell Neoplasms D Baydar Et Almentioning

confidence: 78%

“…Rare giant cells displayed one or two p53-positive nuclei (7) lesions with the classical morphology of osteoclastic giant-cell tumors. Osteoclastic giant-cell tumors are rarely seen involving the urothelial tract, the first case described by Kimura et al 17 We are aware of o20 reports in the English literature of osteoclast-like giant-cell tumors within the bladder or renal pelvis ( Table 5).…”

Section: Osteoclast-like Giant-cell Neoplasms D Baydar Et Almentioning

confidence: 98%

“…[1][2][3][4][5][6][7][8][9] To the best of our knowledge, less than 20 case reports (maximum two cases per report) of osteoclast-like giant-cell tumor of the urothelial tract have been published in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Our study is the largest series in the literature of osteoclast-like giant-cell tumors arising in the urinary tract, and includes six patients. The current study was undertaken to more fully define the clinical and pathologic features of these tumors, and to utilize antibodies to CD51 and CD54, specific markers for osteoclasts, to shed light into their histogenesis.…”

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confidence: 99%

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Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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Osteoclast-like giant-cell neoplasms of the urinary tract are rare. They are composed of ovoid or spindle-shaped mononuclear cells with evenly spaced osteoclast-like giant cells. Terminology, histogenesis, and biologic behavior of these tumors remain controversial. Six cases of osteoclast-like giant-cell neoplasms of the urinary tract were identified from the consultation files of two of the authors. Patients were all male and elderly (range 65-82), with the exception of one 39-year-old male. In all, 3/6 tumors developed in the bladder and 3/6 in the renal pelvis. Size ranged from 5 to 11 cm. One bladder and three renal pelvis tumors were high stage (pT3) at time of presentation. Adjacent to the osteoclast-like giant-cell neoplasm in the same specimen, all patients had urothelial carcinoma in situ and/or high-grade papillary urothelial carcinoma. Multinucleated cells had identical morphological and immunohistochemical properties of osteoclasts; positive for CD-68, LCA, CD51 and CD54, and negative for cytokeratins and EMA. Varying percentages of mononuclear cells expressed a-smooth muscle actin (4/6), desmin (1/6), S-100 (4/6), LCA (2/6) and CD68 (6/6). However, mononuclear cells were also positive for epithelial markers in 4/6 tumors (cytokeratins AE-1/AE-3, Cam 5.2, CK7 and/or EMA). p53 stained mononuclear tumor cells in three cases, paralleling the staining on the accompanying urothelial carcinoma. Ki-67 stained mononuclear tumor cells, but not osteoclast-like giant cells. Follow-up data were available in five cases. One patient developed recurrence of noninvasive urothelial carcinoma and is still alive. Four patients were dead due to disease within 15 months, three with distant metastases. The intimate association of these tumors with urothelial carcinoma along with their immunohistochemical profile supports an epithelial origin for the mononuclear cells and non-neoplastic reactive histiocytic lineage for the osteoclast-like giant cells.

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Section: Osteoclast-like Giant-cell Neoplasms D Baydar Et Almentioning

confidence: 78%

Section: Osteoclast-like Giant-cell Neoplasms D Baydar Et Almentioning

confidence: 98%

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confidence: 99%

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Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

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“…In most instances, the giant cell component has an osteoclast-like appearance and is related to stromal hemorrhage. This situation has been reported in thyroid gland [6], pancreas [7], liver [12], gall bladder [8], salivary glands [5], colon [4], ovary [17], kidney [3], renal pelvis [11], urinary bladder [10], breast [19], and larynx [16]. In other cases, often from lung origin [1,2,9,15] but also occurring in pancreas [13], urinary bladder [10], and other sites, the giant cells are neoplastic and are associated with poor differentiation and dismal prognosis.…”

Section: Introductionmentioning

confidence: 59%

“…Hemorrhage-associated osteoclast-like giant cells have been reported in carcinomas from different organs [4,5,6,7,8,9,11,12,15,16,17,19] and this feature does not bear any relationship with outcome. Conversely, giant cells of epithelial origin found in carcinomas, particularly from lung, pancreas or urinary bladder [1,2,10,13], are indicative of a high degree of anaplasia and poor prognosis.…”

Section: Discussionmentioning

confidence: 98%

Renal cell carcinoma with syncytial giant cell component

et al. 2001

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We report a case of clear cell renal cell carcinoma in which a prominent multinucleated giant cell component was intermingled with clear, granular, and spindle cells. Histological, ultrastructural, cytometric, and cytogenetic features of giant cells were similar to those of mononucleated cells in the tumor, and therefore they were not from stromal or osteoclast derivation. These giant cells had homogeneous, finely granular, abundant cytoplasm, often with scalloped cell borders, and contained from 5 to more than 50 nuclei, all of them very similar in size and shape, with prominent central nucleoli. Occasionally, surrounding inflammatory cells were also engulfed in the cytoplasm. This syncytial appearance was more similar to that of some giant cell carcinomas from the lung than to the pleomorphic giant cells often encountered in high grade renal cell tumors. Although the patient is alive and free of disease 6 years after diagnosis, a longer follow-up will be required to assess the potential prognostic influence of this peculiar histological appearance.

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Osteoclast‐rich undifferentiated carcinoma of the urinary tract: Cytologic findings and literature review

Castelino-Prabhu

Ali

2010

Diagnostic Cytopathology

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The association of urothelial carcinoma with osteoclast-like giant cells is an exceptionally rare event. To our knowledge, there are no published reports of the cytopathologic characteristics of osteoclast-rich undifferentiated carcinoma of the urinary tract. We report herein, the case of a 63-year-old man who was evaluated at The Johns Hopkins Hospital for gross hematuria of 4 months duration. Urinary cytology displayed high-grade malignant cells with scattered osteoclast-like giant cells in a background of acute inflammation and abundant red blood cells. Subsequently, a transurethral tumor resection was performed, which revealed infiltrating undifferentiated carcinoma with osteoclast-like giant cells. The rarity of this neoplasm and its resemblance to other giant cell-rich processes may pose diagnostic difficulties. A review of the important differential diagnoses is also presented.

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Giant cell tumor of the kidney

Cited by 24 publications

References 22 publications

Osteoclast-rich undifferentiated carcinomas of the urinary tract

Osteoclast-rich undifferentiated carcinomas of the urinary tract

Renal cell carcinoma with syncytial giant cell component

Osteoclast‐rich undifferentiated carcinoma of the urinary tract: Cytologic findings and literature review

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