Giant-Cell Tumor of the Tibial Diaphysis

Wilkerson, James A.; Cracchiolo, Andrea

doi:10.2106/00004623-196951060-00016

Cited by 13 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Less than 2% present in the metaphysis or diaphysis 16 and in such instances the pathologist must prove that the lesion is not a giant cell rich osteosarcoma or a bone lesion of hyperparathyroidism.…”

Section: Long and Tubular Bonesmentioning

confidence: 99%

Imaging of giant cell tumor of bone

Purohit¹,

Pardiwala²

2007

Indian J Orthop

View full text Add to dashboard Cite

Giant cell tumor (GCT) of bone is a benign but locally aggressive and destructive lesion generally occurring in skeletally mature individuals. Typically involving the epiphysiometaphyseal region of long bones, the most common sites include the distal femur, proximal tibia and distal radius. On radiographs, GCT demonstrates a lytic lesion centered in the epiphysis but involving the metaphysis and extending at least in part to the adjacent articular cortex. Most are eccentric, but become symmetric and centrally located with growth. Most cases show circumscribed borders or so-called geographical destruction with no periosteal reaction unless a pathological fracture is present. There is no mineralized tumor matrix. Giant cell tumor can produce wide-ranging appearances depending on site, complications such as hemorrhage or pathological fracture and after surgical intervention. This review demonstrates a spectrum of these features and describes the imaging characteristics of GCT in conventional radiographs, computerized tomography scans, magnetic resonance imaging, bone scans, positron emission tomography scans and angiography.

show abstract

Section: Long and Tubular Bonesmentioning

confidence: 99%

Imaging of giant cell tumor of bone

Purohit¹,

Pardiwala²

2007

Indian J Orthop

View full text Add to dashboard Cite

show abstract

“…Those lesions usually occur de novo, but they may also occur as a rare complication of Paget's disease of the bone [3][4][5][6][7][8]. GCT of bone is a rare, aggressive non-malignant lesion [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…GCT of bone is a rare, aggressive non-malignant lesion [1][2][3]. It generally occurs in adults between the ages of 20 and 40 years [3][4][5][6][7][8][9], and is very rarely seen in children or in adults older than 65 years of age [5][6][7][8][9]. GCTs occur in approximately one person in a million per year [9].…”

Section: Introductionmentioning

confidence: 99%

“…Most bone tumors occur in the flared portion near the metaphysis, but GCTs of bone occur almost exclusively in the end portion of long bones next to the joints (epiphysis), and most frequently around the knee joint in the lower end of the thighbone (femur) or the upper end of the shinbone (tibia) [4][5][6]. Other common locations include the wrist (lower end of the lower arm bone), the hip (upper end of the thighbone), the shoulder (upper end of the upper arm bone), and lower back (connection of the spine and pelvis) [4][5][6][7][8][9]. A GCT may spread to the lungs in rare cases [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Other common locations include the wrist (lower end of the lower arm bone), the hip (upper end of the thighbone), the shoulder (upper end of the upper arm bone), and lower back (connection of the spine and pelvis) [4][5][6][7][8][9]. A GCT may spread to the lungs in rare cases [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unusual Coexistence of Giant Cell Tumor and Small Bone Tuberculosis of the Hand - A Case Report

Charach¹,

Grosskopf²,

Shteinvil³

et al. 2016

Global J Med Clin Case Reports

View full text Add to dashboard Cite

Background: The coexistence of giant cell tumor (GCT) and metacarpal bone tuberculosis (TB) of the hand has never been described before in the English written literature. We report here a first observation. Case presentation:We report the case of a 49-year-old male who presented with severe pain in his left hand following a blunt trauma. A plain X-ray of the metacarpal bones showed a pathological fracture of the 4 th metacarpal bone (diaphysis), and computerized tomography and magnetic resonance imaging studies confirmed the diagnosis of destructive (lytic) lesions. biopsy of the metacarpal lesion revealed a GCT, and tissue cultures were positive for mycobacterium tuberculosis (TB). He was treated by a standard 4-drug protocol of isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months and an additional 6 months of isoniazid and rifampicin. He then underwent excision of the metacarpal lesion, and the pathological examination showed a GCT with cultures negative for TB. Conclusions:The correct diagnosis of this unique combination of pathologies (GCT and metacarpal bone TB) depended on a high index of clinical suspicion, referral to mycobacterial laboratory tests, careful histologic examination of tissue samples and especially radiomorphologic findings.AIDS) [15]. When it spreads to the bones, it is also known as "osseous tuberculosis", a form of osteomyelitis [15,16]. We report here a first observation of the coexistence of GCT and metacarpal bone TB of the hand which has never been reported. Case PresentationAn Ukraine-born 49-year-old male presented to the emergency room with severe pain in his left hand, deformation and swelling of the 3,4,5 metacarpal area, following a blunt trauma. A plain X-ray for suspected fracture of the metacarpal bones showed a pathological fracture of the 4 th metacarpal bone (diaphysis) (Figures 1,2). Computerized tomography (CT) and magnetic resonance imaging studies confirmed the diagnosis of destructive (lytic) lesions. A bone scan for determining possible spread of the tumor showed a "hot spot" in the metacarpal bone where the tumor was located. An open biopsy of the metacarpal lesion revealed a GCT, and tissue cultures were positive for mycobacterium tuberculosis (TB).Extensive investigation for the port of entry for mycobacterium included purified protein derivative which was 10 mm. Sputum, urine and gastric lavage cultures were negative. A CT of the chest and abdomen and pelvis were negative both for tumor spread and TB lesions.The patient was asymptomatic except for the pain in his left hand . He was treated for TB by a standard 4-drug protocol of isoniazid, rifampicin, pyrazinamide and ethambutol for 2 months and an additional 6 months of isoniazid and rifampicin. After a full course of therapy for TB, the patient underwent excision (curettage) of the metacarpal lesion, and the pathological examination showed a GCT with cultures negative for TB.

show abstract

Nonepiphyseal giant cell tumor of the long bones. Clinical, radiologic, and pathologic study

Faïn

Unni

Beabout

et al. 1993

Cancer

View full text Add to dashboard Cite

Background. Giant cell tumors (GCT) usually involve the epiphyses of long bones and only rarely involve the metaphysis or diaphysis without epiphyseal extension. Methods. This report presents the clinical and pathologic features of 14 patients with metaphyseal and diaphyseal GCT. Of these tumors, 10 were metaphyseal; 2, metadiaphyseal; and 2, diaphyseal. Results. The sites of involvement included the proximal tibia in six patients, distal radius in three, proximal fibula in one, distal fibula in one, distal ulna in one, proximal humerus in one, and distal femur in one. Radiographically, the tumors were lucent, and the majority were sharply marginated without sclerosis. By contrast with conventional epiphyseal GCT, which generally appear in the mature skeleton, a large proportion (50%) of the GCT in this series were in patients who had open epiphyseal growth plates. Despite the unusual clinical presentation, the behavior of metaphyseal and diaphyseal GCT was similar to that of the typical epiphyseal GCT. There was a 43% recurrence rate after curettage in this series. Conclusions. It is important to distinguish this subset of GCT from other giant cell‐rich lesions more common in these sites, including aneurysmal bone cyst, osteosarcoma, and nonossifying fibroma.

show abstract

Giant-Cell Tumor of the Tibial Diaphysis

Cited by 13 publications

References 0 publications

Imaging of giant cell tumor of bone

Imaging of giant cell tumor of bone

Unusual Coexistence of Giant Cell Tumor and Small Bone Tuberculosis of the Hand - A Case Report

Nonepiphyseal giant cell tumor of the long bones. Clinical, radiologic, and pathologic study

Contact Info

Product

Resources

About