Giant Cell Tumors of Bone Containing Large Amounts of Hemosiderin

Aoki, Jun; Moriya, Kumiko; Yamashita, Kazuhito; Fujioka, Fumio; Karakida, Osamu; Imai, Shun; Sakai, Fumikazu; Imai, Yutaka; Sone, Shusuke

doi:10.1097/00004728-199111000-00023

Cited by 30 publications

(19 citation statements)

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“…MR evidence of intratumonal hemosidenin deposition was reported but not as a common finding [4]. In the present study, however, this phenomenon was more prevalent (63%) than was expected.…”

Section: Discussioncontrasting

confidence: 71%

MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance.

Aoki¹,

Tanikawa²,

Ishii³

et al. 1996

American Journal of Roentgenology

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“…MR evidence of intratumonal hemosidenin deposition was reported but not as a common finding [4]. In the present study, however, this phenomenon was more prevalent (63%) than was expected.…”

Section: Discussioncontrasting

confidence: 71%

MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance.

Aoki¹,

Tanikawa²,

Ishii³

et al. 1996

American Journal of Roentgenology

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“…Low to intermediate signal intensity on T2-weighted images may be a reflection of increased cellularity, a high collagen component or hemosiderin deposition [6,10]. In our patient the mass is predominantly of very high signal on fat-suppressed T2-weighted images and thus is not particularly suggestive of a hemosiderin-laden lesion.…”

Section: Discussionmentioning

confidence: 50%

“…However, giant cells within a lesion are a well-known cause of increased FDG avidity, resulting in false-positive diagnoses of malignancy at PET-CT. Benign fibrous cortical defect/nonossifying fibroma and pigmented villonodular synovitis/tenosynovial giant cell tumor (giant cell tumor of tendon sheath) are common examples [6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of soft tissue: a case report with emphasis on MR imaging

et al. 2015

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Giant cell tumor of soft tissue is a rare neoplasm, histologically resembling giant cell tumor of bone. In this report, we describe a deep and solid giant cell tumor of soft tissue interpreted as a benign soft tissue tumor based on magnetic resonance (MR) findings with hypointense to intermediate signals on T2-weighted images and impeded diffusivity (water movement) on diffusion-weighted imaging (DWI), which could suggest a giant-cell-containing benign soft tissue tumor, despite the malignancy suggested by 18F-fluorodeoxyglucose positron emission tomography-computed tomography in a 35-year-old male. To our knowledge, this report introduces the first deep, solid giant cell tumor of soft tissue with MR features of a giant-cell-containing benign soft tissue tumor, despite the malignancy-mimicking findings on 18F-FDG PET-CT.

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“…One scenario considered was a possible thyroid malignancy with multiple bone metastases; however, the biopsy of the said gingival tumour was interpreted as a peripheral giant cell tumour. Brown tumours are easily confused with giant cell tumours by histology 3. The occurrence of brown tumours in hyperparathyroidism, once part of the classical form, is now considered rare in the first world, but is still found in developing countries.…”

Section: Differential Diagnosismentioning

confidence: 99%

Multiple brown tumours from parathyroid carcinoma

et al. 2016

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We report a case of a 29-year-old woman who suffered from severe bilateral inguinal pain and left mandibular mass. CT scan showed innumerable expansile osteolytic bone masses on the iliac wings, femur, ribs and vertebral bodies, diffuse skeletal osteopaenia, calyceal lithiasis on the right kidney and a left thyroid mass. Ionised calcium and intact parathyroid hormone (PTH) were elevated. Parathyroid sestamibi scan showed a hyperfunctioning left inferior parathyroid gland. Biopsy of the left mandibular mass was consistent with brown tumour. The patient underwent parathyroidectomy of the enlarged parathyroid gland. Final histopathology, however, revealed parathyroid carcinoma, 4.7 cm in widest dimension, with capsular and vascular space invasion. The patient underwent repeat surgery, specifically, left thyroid lobectomy, isthmectomy and central node dissection. Intact PTH decreased from 681.3 to 74 pg/mL (normal range: 10-65) 24 hours postoperatively. Follow-up at 6 months showed normal serum calcium levels, size reduction of bone lesions and improvement of quality of life.

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Giant Cell Tumors of Bone Containing Large Amounts of Hemosiderin

Cited by 30 publications

References 0 publications

MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance.

MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance.

Giant cell tumor of soft tissue: a case report with emphasis on MR imaging

Multiple brown tumours from parathyroid carcinoma

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