Giant cell tumour in the tendon sheath of the hand: Importance of the type of lesion

Ikeda, Kazuo; Osamura, Naoki; Tomita, Katsuro

doi:10.1080/02844310601159766

Cited by 40 publications

(65 citation statements)

References 10 publications

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“…Macroscopically, the average size of tumours ranged from 1.3 to 2.1 cm (min=0.5 cm, max=5 cm) [1,4,6,8,9,15,18,20,23]. Type I tumours were more frequently detected than type II tumours [78.7% (48/61 patients) vs. 21.3% (13/61 patients)] [1,6].…”

Section: Resultsmentioning

confidence: 99%

“…The most frequent location of the tumour was the index finger (76/256 patients, 29.7%). Other tumour sites were the thumb (33/256 patients, 12.9%), the long (63/256 patients, 24.6%), the ring (43/256 patients, 16.8%) and little (41/256 patients, 16%) fingers [1,6,9,15,20].…”

Section: Resultsmentioning

confidence: 99%

“…In type I, there was a single tumour, which might be round or multilobulated. In type II, there were two or more distinct tumours that were not joined together [1,6].…”

Section: Methodsmentioning

confidence: 99%

“…Four papers [1,6,8,20] included exclusively patients with GCTTS of the phalanges. The other six papers described also tumours from non-digit areas [4,5,9,15,18,23], but only data from patients with GCTTSD were used for further analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The most widely accepted pathogenic hypothesis is reactive or regenerative hyperplasia associated with an inflammatory process [18]. Local excision, with or without radiotherapy, has provided good results [1,4,6,8,9,15,18,20,23]. However, the role of tumour characteristics and adjuvant radiotherapy in recurrence rate has not been clearly addressed to date.…”

Section: Introductionmentioning

confidence: 99%

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Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Fotiadis

Papadopoulos

Svarnas

et al. 2011

Hand (New York, N,Y.)

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Background We reviewed the literature to evaluate the demographic, clinical and histological profile of giant cell tumour of tendon sheath of the digits (GCTTSD). The overall recurrence rate and the factors affecting tumour recurrence were also assessed. Methods We searched for published articles regarding the GCTTSD in the English literature the last 30 years using the PubMed search engine. All retrieved papers were analysed and their reference lists were also screened if relevant. Clinical studies with less than five patients and follow-up less than 2 years were excluded from further evaluation. For each report, information was gathered related to trial characteristics and study population. Location and multicentricity of lesions, kind and severity of symptoms, type of applied treatment modality and histopathological features of the excised tumours were additionally recorded. A meta-analysis for estimating the pooled recurrence rate after surgical excision was also conducted. Statistical significance was assumed for p ≤0.05. Results We found 21 studies with histological confirmation of GCTTS. However, only 10 studies including 605 patients were reviewed according to selection criteria (average follow-up 36.7 to 79 months). The male-to-female ratio was 1:1.47 (p < 0.005) and the mean age ranged from 32 to 51 years. Pain or sensory disturbances reported only in 15.7% and 4.57% of cases, respectively. A definite history of trauma recorded in 5% of lesions. The most frequent tumour location was the index finger (29.7%). In total, 14.8% of patients had tumour recurrence. Type I tumours (single lesions) were more frequently detected (78.7%) than type II tumours (two or more distinct tumours that were not joined together) (21.3%) but the latter were associated with a higher recurrence rate (p < 0.001). Study design also affected the possibility of recurrence as it was lower in prospective studies compared to retrospective studies (p = 0.003). Even though bone erosion was detected in 28.39%, recurrence was not more common in this group. In addition, recurrence was not significantly associated with a specific finger or phalanx. Conclusions Intrinsic biology of the tumour seems to play a more fundamental role in recurrence than tumour location or local invasiveness. More prospective welldesigned studies including a large number of cases are necessary to identify tumours prone to recurrence and determine the proper treatment protocol for each individual patient.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…In type I, there was a single tumour, which might be round or multilobulated. In type II, there were two or more distinct tumours that were not joined together [1,6].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Fotiadis

Papadopoulos

Svarnas

et al. 2011

Hand (New York, N,Y.)

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Nodular giant cell tumour of the tendon sheath of the hand: analysis of eighty-four cases—diagnostic decisions and outcome

Lautenbach

Kim

Millrose

et al. 2013

International Orthopaedics (SICOT)

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Our data on the nodular GCTTS are in accordance with published data concerning the age distribution, gender distribution, and localisation. No soft-tissue imaging method is superior for the diagnosis of nodular GCTTS or for the preoperative planning. A preoperative MRI may not be necessary as clinical and ultrasound examination are sufficient. To exclude bony erosions, a preoperative X-ray is necessary.

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Giant cell tumour of the flexor tendon sheath of the hand: analysis of 27 cases

2011

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Giant cell tumour of the tendon sheath (GCTTS) is a slowly progressing benign tumour arising from synovial cells of tendon sheaths. It is one of the most common soft tissue tumours in the hand. We report a retrospective study of 27 proven GCTTS of the hand. The mean length of follow-up was 4.5 years (17 months-8.5 years). Radiographic findings are useful and may prove of great diagnostic value. The positive diagnosis was provided by the pathology examination after complete excision that was performed in all patients. The recurrence was noted in two surgically managed cases. The excision should be meticulous and complete in order to avoid recurrence.

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Giant cell tumour in the tendon sheath of the hand: Importance of the type of lesion

Cited by 40 publications

References 10 publications

Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Giant Cell Tumour of Tendon Sheath of the Digits. A Systematic Review

Nodular giant cell tumour of the tendon sheath of the hand: analysis of eighty-four cases—diagnostic decisions and outcome

Giant cell tumour of the flexor tendon sheath of the hand: analysis of 27 cases

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