Giant‐cell tumour of the salivary gland with associated carcinosarcoma

Carcinosarcoma of the parotid gland featuring foci of malignant giant cell tumor

“…In contrast to the giant cell tumor of the bone, which is believed to be of histiocytic origin, the mononuclear cells of salivary gland osteoclast-like giant cell tumors exhibit an epithelial immunophenotype (3) . In at least one case of coexistent malignant giant cell tumor and carcinosarcoma, the tumor cells (either giant cells or mononuclear cells) did not express cytokeratin (5) . This result is in accordance with our observations, which indicated that CD68-positive giant cells were negative for cytokeratin.…”

“…To the best of our knowledge, only two cases of carcinosarcoma of the parotid gland featuring areas of malignant giant cell tumor resembling their counterparts in the bone and soft tissue have been reported (5,8) . The first case was a 66-year-old female patient with a 5 cm parotid mass, in which 80% of the tumor was c omprised of malignant giant cell tumor, while a minor portion consisted of salivary duct carcinoma with foci of osteosarcoma (5) .…”

“…The first case was a 66-year-old female patient with a 5 cm parotid mass, in which 80% of the tumor was c omprised of malignant giant cell tumor, while a minor portion consisted of salivary duct carcinoma with foci of osteosarcoma (5) . In the second report, a 60-year-old female patient presented a 5 cm parotid mass with four microscopic patterns: undifferentiated carcinoma, undifferentiated sarcoma, osteosarcoma and malignant giant cell tumor (8) .…”

Primary Giant Cell Tumor of Soft Tissue in the Mental Region

“…As reported in the recent review [28][29][30] , most cases of the GCT-ST are arose from extremities involving either superficial or deep soft tissue. From our review of all the English-language literature, seventeen cases, including our case, were identified as GCT-ST arose in the oral and maxillofacial region [13][14][15][16][17][18][19][20][21][22][23][24][25] . About 82 % (14/ 17) have occurred in the parotid gland, most of which were associated with a carcinomatous component.…”

“…Primary GCT of soft tissue (GCT-ST) was originally demonstrated by Salm and Sissons in 1972 9) , followed shortly by Guccion and Enzinger 10) . In the oral and maxillofacial region, not frequent site for GCT, most cases affect the mandible and maxilla 2,11,12) and some cases located in the salivary gland [13][14][15][16][17][18][19][20][21][22][23][24] or nasal cavity 25) have been reported as primary soft tissue analogue in this region. Despite the majority of GCT in the oral and maxillofacial region are histologically comprised of an abundance of multinucleate giant cells and homogeneous population of round to polygonal mononuclear cells in the background 11) with poor cellular atypia and mitotic figures, some of them have revealed a carcinomatous component [13][14][15][17][18][19][20][22][23][24] , local recurrence 2,3) or malignant transformation like those in the extremities.…”